Specific Patterns of White Matter Alterations Help Distinguishing Alzheimer's and Vascular Dementia
Alzheimer disease (AD) and vascular dementia (VaD) together represent the majority of dementia cases. Since their neuropsychological profiles often overlap and white matter lesions are observed in elderly subjects including AD, differentiating between VaD and AD can be difficult. Characterization of...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-04-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnins.2018.00274/full |
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| author | Fulvia Palesi Fulvia Palesi Andrea De Rinaldis Andrea De Rinaldis Paolo Vitali Paolo Vitali Gloria Castellazzi Gloria Castellazzi Letizia Casiraghi Letizia Casiraghi Giancarlo Germani Giancarlo Germani Sara Bernini Nicoletta Anzalone Matteo Cotta Ramusino Matteo Cotta Ramusino Federica M. Denaro Elena Sinforiani Alfredo Costa Alfredo Costa Giovanni Magenes Egidio D'Angelo Egidio D'Angelo Claudia A. M. Gandini Wheeler-Kingshott Claudia A. M. Gandini Wheeler-Kingshott Claudia A. M. Gandini Wheeler-Kingshott Giuseppe Micieli |
| author_facet | Fulvia Palesi Fulvia Palesi Andrea De Rinaldis Andrea De Rinaldis Paolo Vitali Paolo Vitali Gloria Castellazzi Gloria Castellazzi Letizia Casiraghi Letizia Casiraghi Giancarlo Germani Giancarlo Germani Sara Bernini Nicoletta Anzalone Matteo Cotta Ramusino Matteo Cotta Ramusino Federica M. Denaro Elena Sinforiani Alfredo Costa Alfredo Costa Giovanni Magenes Egidio D'Angelo Egidio D'Angelo Claudia A. M. Gandini Wheeler-Kingshott Claudia A. M. Gandini Wheeler-Kingshott Claudia A. M. Gandini Wheeler-Kingshott Giuseppe Micieli |
| author_sort | Fulvia Palesi |
| collection | DOAJ |
| description | Alzheimer disease (AD) and vascular dementia (VaD) together represent the majority of dementia cases. Since their neuropsychological profiles often overlap and white matter lesions are observed in elderly subjects including AD, differentiating between VaD and AD can be difficult. Characterization of these different forms of dementia would benefit by identification of quantitative imaging biomarkers specifically sensitive to AD or VaD. Parameters of microstructural abnormalities derived from diffusion tensor imaging (DTI) have been reported to be helpful in differentiating between dementias, but only few studies have used them to compare AD and VaD with a voxelwise approach. Therefore, in this study a whole brain statistical analysis was performed on DTI data of 93 subjects (31 AD, 27 VaD, and 35 healthy controls—HC) to identify specific white matter patterns of alteration in patients affected by VaD and AD with respect to HC. Parahippocampal tracts were found to be mainly affected in AD, while VaD showed more spread white matter damages associated with thalamic radiations involvement. The genu of the corpus callosum was predominantly affected in VaD, while the splenium was predominantly affected in AD revealing the existence of specific patterns of alteration useful in distinguishing between VaD and AD. Therefore, DTI parameters of these regions could be informative to understand the pathogenesis and support the etiological diagnosis of dementia. Further studies on larger cohorts of subjects, characterized for brain amyloidosis, will allow to confirm and to integrate the present findings and, furthermore, to elucidate the mechanisms of mixed dementia. These steps will be essential to translate these advances to clinical practice. |
| first_indexed | 2024-12-10T19:20:06Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-10T19:20:06Z |
| publishDate | 2018-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-ba92c44dccae4b06940600735c04011a2022-12-22T01:36:31ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2018-04-011210.3389/fnins.2018.00274344648Specific Patterns of White Matter Alterations Help Distinguishing Alzheimer's and Vascular DementiaFulvia Palesi0Fulvia Palesi1Andrea De Rinaldis2Andrea De Rinaldis3Paolo Vitali4Paolo Vitali5Gloria Castellazzi6Gloria Castellazzi7Letizia Casiraghi8Letizia Casiraghi9Giancarlo Germani10Giancarlo Germani11Sara Bernini12Nicoletta Anzalone13Matteo Cotta Ramusino14Matteo Cotta Ramusino15Federica M. Denaro16Elena Sinforiani17Alfredo Costa18Alfredo Costa19Giovanni Magenes20Egidio D'Angelo21Egidio D'Angelo22Claudia A. M. Gandini Wheeler-Kingshott23Claudia A. M. Gandini Wheeler-Kingshott24Claudia A. M. Gandini Wheeler-Kingshott25Giuseppe Micieli26Department of Physics, University of Pavia, Pavia, ItalyBrain Connectivity Center, IRCCS Mondino Foundation, Pavia, ItalyBrain Connectivity Center, IRCCS Mondino Foundation, Pavia, ItalyDepartment of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, ItalyBrain MRI 3T Mondino Research Center, IRCCS Mondino Foundation, Pavia, ItalyNeuroradiology Unit, IRCCS Mondino Foundation, Pavia, ItalyBrain Connectivity Center, IRCCS Mondino Foundation, Pavia, ItalyDepartment of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, ItalyBrain Connectivity Center, IRCCS Mondino Foundation, Pavia, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, ItalyBrain MRI 3T Mondino Research Center, IRCCS Mondino Foundation, Pavia, ItalyNeuroradiology Unit, IRCCS Mondino Foundation, Pavia, ItalyAlzheimer's Disease Assessment Unit, Laboratory of Neuropsychology, IRCCS Mondino Foundation, Pavia, ItalyScientific Institute H. S. Raffaele, Milan, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, ItalyAlzheimer's Disease Assessment Unit, Laboratory of Neuropsychology, IRCCS Mondino Foundation, Pavia, ItalyDepartment of Emergency Neurology, IRCCS Mondino Foundation, Pavia, ItalyAlzheimer's Disease Assessment Unit, Laboratory of Neuropsychology, IRCCS Mondino Foundation, Pavia, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, ItalyAlzheimer's Disease Assessment Unit, Laboratory of Neuropsychology, IRCCS Mondino Foundation, Pavia, ItalyDepartment of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, ItalyBrain Connectivity Center, IRCCS Mondino Foundation, Pavia, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, ItalyBrain MRI 3T Mondino Research Center, IRCCS Mondino Foundation, Pavia, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy0Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United KingdomDepartment of Emergency Neurology, IRCCS Mondino Foundation, Pavia, ItalyAlzheimer disease (AD) and vascular dementia (VaD) together represent the majority of dementia cases. Since their neuropsychological profiles often overlap and white matter lesions are observed in elderly subjects including AD, differentiating between VaD and AD can be difficult. Characterization of these different forms of dementia would benefit by identification of quantitative imaging biomarkers specifically sensitive to AD or VaD. Parameters of microstructural abnormalities derived from diffusion tensor imaging (DTI) have been reported to be helpful in differentiating between dementias, but only few studies have used them to compare AD and VaD with a voxelwise approach. Therefore, in this study a whole brain statistical analysis was performed on DTI data of 93 subjects (31 AD, 27 VaD, and 35 healthy controls—HC) to identify specific white matter patterns of alteration in patients affected by VaD and AD with respect to HC. Parahippocampal tracts were found to be mainly affected in AD, while VaD showed more spread white matter damages associated with thalamic radiations involvement. The genu of the corpus callosum was predominantly affected in VaD, while the splenium was predominantly affected in AD revealing the existence of specific patterns of alteration useful in distinguishing between VaD and AD. Therefore, DTI parameters of these regions could be informative to understand the pathogenesis and support the etiological diagnosis of dementia. Further studies on larger cohorts of subjects, characterized for brain amyloidosis, will allow to confirm and to integrate the present findings and, furthermore, to elucidate the mechanisms of mixed dementia. These steps will be essential to translate these advances to clinical practice.http://journal.frontiersin.org/article/10.3389/fnins.2018.00274/fullAlzheimer's diseasevascular dementiaDTIsplenium of corpus callosumgenu of corpus callosumparahippocampal gyri |
| spellingShingle | Fulvia Palesi Fulvia Palesi Andrea De Rinaldis Andrea De Rinaldis Paolo Vitali Paolo Vitali Gloria Castellazzi Gloria Castellazzi Letizia Casiraghi Letizia Casiraghi Giancarlo Germani Giancarlo Germani Sara Bernini Nicoletta Anzalone Matteo Cotta Ramusino Matteo Cotta Ramusino Federica M. Denaro Elena Sinforiani Alfredo Costa Alfredo Costa Giovanni Magenes Egidio D'Angelo Egidio D'Angelo Claudia A. M. Gandini Wheeler-Kingshott Claudia A. M. Gandini Wheeler-Kingshott Claudia A. M. Gandini Wheeler-Kingshott Giuseppe Micieli Specific Patterns of White Matter Alterations Help Distinguishing Alzheimer's and Vascular Dementia Frontiers in Neuroscience Alzheimer's disease vascular dementia DTI splenium of corpus callosum genu of corpus callosum parahippocampal gyri |
| title | Specific Patterns of White Matter Alterations Help Distinguishing Alzheimer's and Vascular Dementia |
| title_full | Specific Patterns of White Matter Alterations Help Distinguishing Alzheimer's and Vascular Dementia |
| title_fullStr | Specific Patterns of White Matter Alterations Help Distinguishing Alzheimer's and Vascular Dementia |
| title_full_unstemmed | Specific Patterns of White Matter Alterations Help Distinguishing Alzheimer's and Vascular Dementia |
| title_short | Specific Patterns of White Matter Alterations Help Distinguishing Alzheimer's and Vascular Dementia |
| title_sort | specific patterns of white matter alterations help distinguishing alzheimer s and vascular dementia |
| topic | Alzheimer's disease vascular dementia DTI splenium of corpus callosum genu of corpus callosum parahippocampal gyri |
| url | http://journal.frontiersin.org/article/10.3389/fnins.2018.00274/full |
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