SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub
SETBP1 variants occur as somatic mutations in several malignancies and as de novo germline mutations in developmental disorders. Here the authors provide evidence that SETBP1 binds to gDNA in AT-rich promoter regions to promote target gene upregulation, indicating SETBP1 functions directly to regula...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04462-8 |
| _version_ | 1818681785232392192 |
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| author | Rocco Piazza Vera Magistroni Sara Redaelli Mario Mauri Luca Massimino Alessandro Sessa Marco Peronaci Maciej Lalowski Rabah Soliymani Caterina Mezzatesta Alessandra Pirola Federica Banfi Alicia Rubio Delphine Rea Fabio Stagno Emilio Usala Bruno Martino Leonardo Campiotti Michele Merli Francesco Passamonti Francesco Onida Alessandro Morotti Francesca Pavesi Marco Bregni Vania Broccoli Marc Baumann Carlo Gambacorti-Passerini |
| author_facet | Rocco Piazza Vera Magistroni Sara Redaelli Mario Mauri Luca Massimino Alessandro Sessa Marco Peronaci Maciej Lalowski Rabah Soliymani Caterina Mezzatesta Alessandra Pirola Federica Banfi Alicia Rubio Delphine Rea Fabio Stagno Emilio Usala Bruno Martino Leonardo Campiotti Michele Merli Francesco Passamonti Francesco Onida Alessandro Morotti Francesca Pavesi Marco Bregni Vania Broccoli Marc Baumann Carlo Gambacorti-Passerini |
| author_sort | Rocco Piazza |
| collection | DOAJ |
| description | SETBP1 variants occur as somatic mutations in several malignancies and as de novo germline mutations in developmental disorders. Here the authors provide evidence that SETBP1 binds to gDNA in AT-rich promoter regions to promote target gene upregulation, indicating SETBP1 functions directly to regulate transcription. |
| first_indexed | 2024-12-17T10:08:28Z |
| format | Article |
| id | doaj.art-ba93d3f63f634212b28426582bbfc01b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:08:28Z |
| publishDate | 2018-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ba93d3f63f634212b28426582bbfc01b2022-12-21T21:53:06ZengNature PortfolioNature Communications2041-17232018-06-019111310.1038/s41467-018-04462-8SETBP1 induces transcription of a network of development genes by acting as an epigenetic hubRocco Piazza0Vera Magistroni1Sara Redaelli2Mario Mauri3Luca Massimino4Alessandro Sessa5Marco Peronaci6Maciej Lalowski7Rabah Soliymani8Caterina Mezzatesta9Alessandra Pirola10Federica Banfi11Alicia Rubio12Delphine Rea13Fabio Stagno14Emilio Usala15Bruno Martino16Leonardo Campiotti17Michele Merli18Francesco Passamonti19Francesco Onida20Alessandro Morotti21Francesca Pavesi22Marco Bregni23Vania Broccoli24Marc Baumann25Carlo Gambacorti-Passerini26Department of Medicine and Surgery, University of Milano-Bicocca and San Gerardo hospitalDepartment of Medicine and Surgery, University of Milano-Bicocca and San Gerardo hospitalDepartment of Medicine and Surgery, University of Milano-Bicocca and San Gerardo hospitalDepartment of Medicine and Surgery, University of Milano-Bicocca and San Gerardo hospitalDepartment of Medicine and Surgery, University of Milano-Bicocca and San Gerardo hospitalStem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific InstituteDepartment of Medicine and Surgery, University of Milano-Bicocca and San Gerardo hospitalDepartment of Biochemistry and Developmental Biology, Faculty of Medicine, Meilahti Clinical Proteomics Core Facility, University of HelsinkiDepartment of Biochemistry and Developmental Biology, Faculty of Medicine, Meilahti Clinical Proteomics Core Facility, University of HelsinkiDepartment of Medicine and Surgery, University of Milano-Bicocca and San Gerardo hospitalDepartment of Medicine and Surgery, University of Milano-Bicocca and San Gerardo hospitalStem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific InstituteStem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific InstituteService d’Hématologie Adulte, Hôpital Saint-LouisChair and Hematology Section, Ferrarotto Hospital, AOU PoliclinicoAzienda Brotzu U.O. Ematologia e CTMO, Ospedale BusincoUO Ematologia Azienda Ospedaliera “BIANCHI MELACRINO MORELLI”Dipartimento Medicina Clinica e Sperimentale, Università InsubriaDivision of Hematology, University Hospital Ospedale di Circolo e Fondazione MacchiHematology, Dipartimento di Medicina Clinica e Sperimentale, University of VareseBMT Center - Oncohematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of MilanDepartment of Clinical and Biological Sciences, University of TorinoHematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific InstituteOncology Unit, ASST Valle Olona, Ospedale di Circolo di Busto ArsizioStem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific InstituteDepartment of Biochemistry and Developmental Biology, Faculty of Medicine, Meilahti Clinical Proteomics Core Facility, University of HelsinkiDepartment of Medicine and Surgery, University of Milano-Bicocca and San Gerardo hospitalSETBP1 variants occur as somatic mutations in several malignancies and as de novo germline mutations in developmental disorders. Here the authors provide evidence that SETBP1 binds to gDNA in AT-rich promoter regions to promote target gene upregulation, indicating SETBP1 functions directly to regulate transcription.https://doi.org/10.1038/s41467-018-04462-8 |
| spellingShingle | Rocco Piazza Vera Magistroni Sara Redaelli Mario Mauri Luca Massimino Alessandro Sessa Marco Peronaci Maciej Lalowski Rabah Soliymani Caterina Mezzatesta Alessandra Pirola Federica Banfi Alicia Rubio Delphine Rea Fabio Stagno Emilio Usala Bruno Martino Leonardo Campiotti Michele Merli Francesco Passamonti Francesco Onida Alessandro Morotti Francesca Pavesi Marco Bregni Vania Broccoli Marc Baumann Carlo Gambacorti-Passerini SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub Nature Communications |
| title | SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub |
| title_full | SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub |
| title_fullStr | SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub |
| title_full_unstemmed | SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub |
| title_short | SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub |
| title_sort | setbp1 induces transcription of a network of development genes by acting as an epigenetic hub |
| url | https://doi.org/10.1038/s41467-018-04462-8 |
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