KAP degradation by calpain is associated with CK2 phosphorylation and provides a novel mechanism for cyclosporine A-induced proximal tubule injury.

KAP degradation by calpain is associated with CK2 phosphorylation and provides a novel mechanism for cyclosporine A-induced proximal tubule injury.

The use of cyclosporine A (CsA) is limited by its severe nephrotoxicity that includes reversible vasoconstrictor effects and proximal tubule cell injury, the latter associated whith chronic kidney disease progression. The mechanisms of CsA-induced tubular injury, mainly on the S3 segment, have not b...

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Bibliographic Details
Main Authors: Olga Tornavaca, Eduard Sarró, Gloria Pascual, Beatriz Bardaji, M Angeles Montero, M Teresa Salcedo, Maria Plana, Joan López-Hellin, Emilio Itarte, Anna Meseguer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3182248?pdf=render

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http://europepmc.org/articles/PMC3182248?pdf=render

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