KAP degradation by calpain is associated with CK2 phosphorylation and provides a novel mechanism for cyclosporine A-induced proximal tubule injury.
The use of cyclosporine A (CsA) is limited by its severe nephrotoxicity that includes reversible vasoconstrictor effects and proximal tubule cell injury, the latter associated whith chronic kidney disease progression. The mechanisms of CsA-induced tubular injury, mainly on the S3 segment, have not b...
Main Authors: | Olga Tornavaca, Eduard Sarró, Gloria Pascual, Beatriz Bardaji, M Angeles Montero, M Teresa Salcedo, Maria Plana, Joan López-Hellin, Emilio Itarte, Anna Meseguer |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3182248?pdf=render |
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