Quantitative MRI in leukodystrophies
Leukodystrophies constitute a large and heterogeneous group of genetic diseases primarily affecting the white matter of the central nervous system. Different disorders target different white matter structural components. Leukodystrophies are most often progressive and fatal. In recent years, novel t...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221315822300116X |
| _version_ | 1827925827819405312 |
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| author | Menno D. Stellingwerff Petra J.W. Pouwels Stefan D. Roosendaal Frederik Barkhof Marjo S. van der Knaap |
| author_facet | Menno D. Stellingwerff Petra J.W. Pouwels Stefan D. Roosendaal Frederik Barkhof Marjo S. van der Knaap |
| author_sort | Menno D. Stellingwerff |
| collection | DOAJ |
| description | Leukodystrophies constitute a large and heterogeneous group of genetic diseases primarily affecting the white matter of the central nervous system. Different disorders target different white matter structural components. Leukodystrophies are most often progressive and fatal. In recent years, novel therapies are emerging and for an increasing number of leukodystrophies trials are being developed. Objective and quantitative metrics are needed to serve as outcome measures in trials. Quantitative MRI yields information on microstructural properties, such as myelin or axonal content and condition, and on the chemical composition of white matter, in a noninvasive fashion. By providing information on white matter microstructural involvement, quantitative MRI may contribute to the evaluation and monitoring of leukodystrophies. Many distinct MR techniques are available at different stages of development. While some are already clinically applicable, others are less far developed and have only or mainly been applied in healthy subjects. In this review, we explore the background, current status, potential and challenges of available quantitative MR techniques in the context of leukodystrophies. |
| first_indexed | 2024-03-13T05:28:44Z |
| format | Article |
| id | doaj.art-ba943e402c6f45a5b26c86e2ccd3c664 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-03-13T05:28:44Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-ba943e402c6f45a5b26c86e2ccd3c6642023-06-15T04:55:58ZengElsevierNeuroImage: Clinical2213-15822023-01-0138103427Quantitative MRI in leukodystrophiesMenno D. Stellingwerff0Petra J.W. Pouwels1Stefan D. Roosendaal2Frederik Barkhof3Marjo S. van der Knaap4Amsterdam UMC Location Vrije Universiteit Amsterdam, Child Neurology, Emma Children’s Hospital, and Amsterdam Neuroscience, De Boelelaan 1117, Amsterdam, the NetherlandsAmsterdam UMC Location Vrije Universiteit Amsterdam, Department of Radiology and Nuclear Medicine, and Amsterdam Neuroscience, De Boelelaan 1117, Amsterdam, the NetherlandsAmsterdam UMC Location University of Amsterdam, Department of Radiology, Meibergdreef 9, Amsterdam, the NetherlandsAmsterdam UMC Location Vrije Universiteit Amsterdam, Department of Radiology and Nuclear Medicine, and Amsterdam Neuroscience, De Boelelaan 1117, Amsterdam, the Netherlands; University College London, Institutes of Neurology and Healthcare Engineering, London, UKAmsterdam UMC Location Vrije Universiteit Amsterdam, Child Neurology, Emma Children’s Hospital, and Amsterdam Neuroscience, De Boelelaan 1117, Amsterdam, the Netherlands; Vrije Universiteit Amsterdam, Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, De Boelelaan 1105, Amsterdam, the Netherlands; Corresponding author.Leukodystrophies constitute a large and heterogeneous group of genetic diseases primarily affecting the white matter of the central nervous system. Different disorders target different white matter structural components. Leukodystrophies are most often progressive and fatal. In recent years, novel therapies are emerging and for an increasing number of leukodystrophies trials are being developed. Objective and quantitative metrics are needed to serve as outcome measures in trials. Quantitative MRI yields information on microstructural properties, such as myelin or axonal content and condition, and on the chemical composition of white matter, in a noninvasive fashion. By providing information on white matter microstructural involvement, quantitative MRI may contribute to the evaluation and monitoring of leukodystrophies. Many distinct MR techniques are available at different stages of development. While some are already clinically applicable, others are less far developed and have only or mainly been applied in healthy subjects. In this review, we explore the background, current status, potential and challenges of available quantitative MR techniques in the context of leukodystrophies.http://www.sciencedirect.com/science/article/pii/S221315822300116XQuantitative MRIWhite matter disordersLeukodystrophiesMyelin imaging |
| spellingShingle | Menno D. Stellingwerff Petra J.W. Pouwels Stefan D. Roosendaal Frederik Barkhof Marjo S. van der Knaap Quantitative MRI in leukodystrophies NeuroImage: Clinical Quantitative MRI White matter disorders Leukodystrophies Myelin imaging |
| title | Quantitative MRI in leukodystrophies |
| title_full | Quantitative MRI in leukodystrophies |
| title_fullStr | Quantitative MRI in leukodystrophies |
| title_full_unstemmed | Quantitative MRI in leukodystrophies |
| title_short | Quantitative MRI in leukodystrophies |
| title_sort | quantitative mri in leukodystrophies |
| topic | Quantitative MRI White matter disorders Leukodystrophies Myelin imaging |
| url | http://www.sciencedirect.com/science/article/pii/S221315822300116X |
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