Is Memantine a Potential Therapeutic for Rett Syndrome?
Memantine is a low-affinity voltage-dependent non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist. It is classified as a neuroprotective aminoadamantane. It does not cure or reverse Alzheimer’s but it does effectively treat symptoms, slows the progression of the disease and allows many p...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2013-12-01
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Series: | Frontiers in Neuroscience |
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00245/full |
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author | Olivia eBello Kelsey eBlair Christopher eChapleau Jennifer eLarimore |
author_facet | Olivia eBello Kelsey eBlair Christopher eChapleau Jennifer eLarimore |
author_sort | Olivia eBello |
collection | DOAJ |
description | Memantine is a low-affinity voltage-dependent non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist. It is classified as a neuroprotective aminoadamantane. It does not cure or reverse Alzheimer’s but it does effectively treat symptoms, slows the progression of the disease and allows many patients to perform daily cognitive activities with clear thoughts. Based on it’s success in patients with Alzheimer’s, memantine has been tested in other neurological disorders with impaired learning and memory. In this review, we will discuss the success and failures of memantine in Downs Syndrome and Fragile X research and from those results, assess the potential benefit of memantine in Rett Syndrome. |
first_indexed | 2024-12-10T11:01:44Z |
format | Article |
id | doaj.art-ba944fc92ad84970a9f63b1fba4476b2 |
institution | Directory Open Access Journal |
issn | 1662-453X |
language | English |
last_indexed | 2024-12-10T11:01:44Z |
publishDate | 2013-12-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Neuroscience |
spelling | doaj.art-ba944fc92ad84970a9f63b1fba4476b22022-12-22T01:51:40ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2013-12-01710.3389/fnins.2013.0024564862Is Memantine a Potential Therapeutic for Rett Syndrome?Olivia eBello0Kelsey eBlair1Christopher eChapleau2Jennifer eLarimore3Agnes Scott CollegeUniversity of Alabama at BirminghamUniversity of Alabama at BirminghamAgnes Scott CollegeMemantine is a low-affinity voltage-dependent non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist. It is classified as a neuroprotective aminoadamantane. It does not cure or reverse Alzheimer’s but it does effectively treat symptoms, slows the progression of the disease and allows many patients to perform daily cognitive activities with clear thoughts. Based on it’s success in patients with Alzheimer’s, memantine has been tested in other neurological disorders with impaired learning and memory. In this review, we will discuss the success and failures of memantine in Downs Syndrome and Fragile X research and from those results, assess the potential benefit of memantine in Rett Syndrome.http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00245/fullDown SyndromeFragile X SyndromeMemantineRett SyndromeAlzheimer’s disease.Downs Syndrome |
spellingShingle | Olivia eBello Kelsey eBlair Christopher eChapleau Jennifer eLarimore Is Memantine a Potential Therapeutic for Rett Syndrome? Frontiers in Neuroscience Down Syndrome Fragile X Syndrome Memantine Rett Syndrome Alzheimer’s disease. Downs Syndrome |
title | Is Memantine a Potential Therapeutic for Rett Syndrome? |
title_full | Is Memantine a Potential Therapeutic for Rett Syndrome? |
title_fullStr | Is Memantine a Potential Therapeutic for Rett Syndrome? |
title_full_unstemmed | Is Memantine a Potential Therapeutic for Rett Syndrome? |
title_short | Is Memantine a Potential Therapeutic for Rett Syndrome? |
title_sort | is memantine a potential therapeutic for rett syndrome |
topic | Down Syndrome Fragile X Syndrome Memantine Rett Syndrome Alzheimer’s disease. Downs Syndrome |
url | http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00245/full |
work_keys_str_mv | AT oliviaebello ismemantineapotentialtherapeuticforrettsyndrome AT kelseyeblair ismemantineapotentialtherapeuticforrettsyndrome AT christopherechapleau ismemantineapotentialtherapeuticforrettsyndrome AT jenniferelarimore ismemantineapotentialtherapeuticforrettsyndrome |