Is Memantine a Potential Therapeutic for Rett Syndrome?

Memantine is a low-affinity voltage-dependent non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist. It is classified as a neuroprotective aminoadamantane. It does not cure or reverse Alzheimer’s but it does effectively treat symptoms, slows the progression of the disease and allows many p...

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Main Authors: Olivia eBello, Kelsey eBlair, Christopher eChapleau, Jennifer eLarimore
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00245/full
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author Olivia eBello
Kelsey eBlair
Christopher eChapleau
Jennifer eLarimore
author_facet Olivia eBello
Kelsey eBlair
Christopher eChapleau
Jennifer eLarimore
author_sort Olivia eBello
collection DOAJ
description Memantine is a low-affinity voltage-dependent non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist. It is classified as a neuroprotective aminoadamantane. It does not cure or reverse Alzheimer’s but it does effectively treat symptoms, slows the progression of the disease and allows many patients to perform daily cognitive activities with clear thoughts. Based on it’s success in patients with Alzheimer’s, memantine has been tested in other neurological disorders with impaired learning and memory. In this review, we will discuss the success and failures of memantine in Downs Syndrome and Fragile X research and from those results, assess the potential benefit of memantine in Rett Syndrome.
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spelling doaj.art-ba944fc92ad84970a9f63b1fba4476b22022-12-22T01:51:40ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2013-12-01710.3389/fnins.2013.0024564862Is Memantine a Potential Therapeutic for Rett Syndrome?Olivia eBello0Kelsey eBlair1Christopher eChapleau2Jennifer eLarimore3Agnes Scott CollegeUniversity of Alabama at BirminghamUniversity of Alabama at BirminghamAgnes Scott CollegeMemantine is a low-affinity voltage-dependent non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist. It is classified as a neuroprotective aminoadamantane. It does not cure or reverse Alzheimer’s but it does effectively treat symptoms, slows the progression of the disease and allows many patients to perform daily cognitive activities with clear thoughts. Based on it’s success in patients with Alzheimer’s, memantine has been tested in other neurological disorders with impaired learning and memory. In this review, we will discuss the success and failures of memantine in Downs Syndrome and Fragile X research and from those results, assess the potential benefit of memantine in Rett Syndrome.http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00245/fullDown SyndromeFragile X SyndromeMemantineRett SyndromeAlzheimer’s disease.Downs Syndrome
spellingShingle Olivia eBello
Kelsey eBlair
Christopher eChapleau
Jennifer eLarimore
Is Memantine a Potential Therapeutic for Rett Syndrome?
Frontiers in Neuroscience
Down Syndrome
Fragile X Syndrome
Memantine
Rett Syndrome
Alzheimer’s disease.
Downs Syndrome
title Is Memantine a Potential Therapeutic for Rett Syndrome?
title_full Is Memantine a Potential Therapeutic for Rett Syndrome?
title_fullStr Is Memantine a Potential Therapeutic for Rett Syndrome?
title_full_unstemmed Is Memantine a Potential Therapeutic for Rett Syndrome?
title_short Is Memantine a Potential Therapeutic for Rett Syndrome?
title_sort is memantine a potential therapeutic for rett syndrome
topic Down Syndrome
Fragile X Syndrome
Memantine
Rett Syndrome
Alzheimer’s disease.
Downs Syndrome
url http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00245/full
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