Association of TLR2 and TLR4 gene polymorphism with susceptibility to wart infections and their response to candida antigen immunotherapy
Background Warts are prevalent human papilloma virus (HPV) infections which can cause physical and psychological problems. Candida antigen immunotherapy is a safe and promising treatment of warts. Toll-like receptors (TLRs) 2 and 4 gene polymorphisms are implicated in susceptibility and progression...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-01-01
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| Series: | Journal of Dermatological Treatment |
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| Online Access: | http://dx.doi.org/10.1080/09546634.2020.1732285 |
| _version_ | 1797683631745925120 |
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| author | Enas A. Tantawy Abdallah A. El-Beyali Maha K. Gohar Zynab S. Ibrahim Mohamed Nasr Ayman Marei |
| author_facet | Enas A. Tantawy Abdallah A. El-Beyali Maha K. Gohar Zynab S. Ibrahim Mohamed Nasr Ayman Marei |
| author_sort | Enas A. Tantawy |
| collection | DOAJ |
| description | Background Warts are prevalent human papilloma virus (HPV) infections which can cause physical and psychological problems. Candida antigen immunotherapy is a safe and promising treatment of warts. Toll-like receptors (TLRs) 2 and 4 gene polymorphisms are implicated in susceptibility and progression of several diseases. Aim To assess the role of TLR2Arg753GLN and TLR4Asp299Gly polymorphisms in susceptibility to HPV wart infections and their possible effect on response to Candida antigen immunotherapy. Patients and methods A total of 78 patients and 78 healthy subjects were enrolled in this case control study. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to detect TLR2Arg753GLN and TLR4Asp299Gly genes polymorphisms. Patients’ lesions were injected with Candida antigens and the response was assessed. Results The mutant AA and GG genotypes of TLR2Arg753GLN and TLR4Asp299Gly were significantly detected in patients than controls (p < .001 and p = .01, respectively). Intralesional Candida antigen injections achieved complete and partial clearance in 62.8 and 20.5% of lesions, respectively. No association was found between the studied polymorphisms and response to Candida antigen injections. Conclusions TLR2Arg753GLN and TLR4Asp299Gly polymorphisms are associated with susceptibility to wart infections, but with no effect on their response to Candida immunotherapy. |
| first_indexed | 2024-03-12T00:17:17Z |
| format | Article |
| id | doaj.art-ba946bfb78fd4f7cb1a8624a56e9cf57 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:17:17Z |
| publishDate | 2022-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-ba946bfb78fd4f7cb1a8624a56e9cf572023-09-15T14:23:05ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532022-01-0133116617210.1080/09546634.2020.17322851732285Association of TLR2 and TLR4 gene polymorphism with susceptibility to wart infections and their response to candida antigen immunotherapyEnas A. Tantawy0Abdallah A. El-Beyali1Maha K. Gohar2Zynab S. Ibrahim3Mohamed Nasr4Ayman Marei5Microbiology and Immunology Department, Faculty of Medicine, Zagazig UniversityMicrobiology and Immunology Department, Faculty of Medicine, Zagazig UniversityMicrobiology and Immunology Department, Faculty of Medicine, Zagazig UniversityMicrobiology and Immunology Department, Faculty of Medicine, Zagazig UniversityDermatology, Venereology and Andrology Department, Faculty of Medicine, Zagazig UniversityMicrobiology and Immunology Department, Faculty of Medicine, Zagazig UniversityBackground Warts are prevalent human papilloma virus (HPV) infections which can cause physical and psychological problems. Candida antigen immunotherapy is a safe and promising treatment of warts. Toll-like receptors (TLRs) 2 and 4 gene polymorphisms are implicated in susceptibility and progression of several diseases. Aim To assess the role of TLR2Arg753GLN and TLR4Asp299Gly polymorphisms in susceptibility to HPV wart infections and their possible effect on response to Candida antigen immunotherapy. Patients and methods A total of 78 patients and 78 healthy subjects were enrolled in this case control study. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to detect TLR2Arg753GLN and TLR4Asp299Gly genes polymorphisms. Patients’ lesions were injected with Candida antigens and the response was assessed. Results The mutant AA and GG genotypes of TLR2Arg753GLN and TLR4Asp299Gly were significantly detected in patients than controls (p < .001 and p = .01, respectively). Intralesional Candida antigen injections achieved complete and partial clearance in 62.8 and 20.5% of lesions, respectively. No association was found between the studied polymorphisms and response to Candida antigen injections. Conclusions TLR2Arg753GLN and TLR4Asp299Gly polymorphisms are associated with susceptibility to wart infections, but with no effect on their response to Candida immunotherapy.http://dx.doi.org/10.1080/09546634.2020.1732285toll-like receptorsgene polymorphismwartscandida antigen |
| spellingShingle | Enas A. Tantawy Abdallah A. El-Beyali Maha K. Gohar Zynab S. Ibrahim Mohamed Nasr Ayman Marei Association of TLR2 and TLR4 gene polymorphism with susceptibility to wart infections and their response to candida antigen immunotherapy Journal of Dermatological Treatment toll-like receptors gene polymorphism warts candida antigen |
| title | Association of TLR2 and TLR4 gene polymorphism with susceptibility to wart infections and their response to candida antigen immunotherapy |
| title_full | Association of TLR2 and TLR4 gene polymorphism with susceptibility to wart infections and their response to candida antigen immunotherapy |
| title_fullStr | Association of TLR2 and TLR4 gene polymorphism with susceptibility to wart infections and their response to candida antigen immunotherapy |
| title_full_unstemmed | Association of TLR2 and TLR4 gene polymorphism with susceptibility to wart infections and their response to candida antigen immunotherapy |
| title_short | Association of TLR2 and TLR4 gene polymorphism with susceptibility to wart infections and their response to candida antigen immunotherapy |
| title_sort | association of tlr2 and tlr4 gene polymorphism with susceptibility to wart infections and their response to candida antigen immunotherapy |
| topic | toll-like receptors gene polymorphism warts candida antigen |
| url | http://dx.doi.org/10.1080/09546634.2020.1732285 |
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