The effects of Ascophyllum nodosum, Camellia sinensis-leaf extract, and their joint interventions on glycolipid and energy metabolism in obese mice
ObjectivesObesity is often associated with glucolipid and/or energy metabolism disorders. Ascophyllum nodosum extract (seaweed extract, SE) and Camellia sinensis-leaf extract (tea extract, TE) have been reported to promote positive metabolic effects through different mechanisms. We investigated the...
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1242157/full |
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| author | Yuhan Xu Yuhan Xu Xiuzhen Jia Xiuzhen Jia Wei Zhang Wei Zhang Qiaoling Xie Qiaoling Xie Meizhen Zhu Meizhen Zhu Zifu Zhao Zifu Zhao Jingyu Hao Jingyu Hao Haoqiu Li Haoqiu Li Jinrui Du Jinrui Du Yan Liu Yan Liu Haotian Feng Haotian Feng Jian He Jian He Hongwei Li Hongwei Li |
| author_facet | Yuhan Xu Yuhan Xu Xiuzhen Jia Xiuzhen Jia Wei Zhang Wei Zhang Qiaoling Xie Qiaoling Xie Meizhen Zhu Meizhen Zhu Zifu Zhao Zifu Zhao Jingyu Hao Jingyu Hao Haoqiu Li Haoqiu Li Jinrui Du Jinrui Du Yan Liu Yan Liu Haotian Feng Haotian Feng Jian He Jian He Hongwei Li Hongwei Li |
| author_sort | Yuhan Xu |
| collection | DOAJ |
| description | ObjectivesObesity is often associated with glucolipid and/or energy metabolism disorders. Ascophyllum nodosum extract (seaweed extract, SE) and Camellia sinensis-leaf extract (tea extract, TE) have been reported to promote positive metabolic effects through different mechanisms. We investigated the effects of SE and TE on metabolic homeostasis in diet-induced obese mice and discussed their functional characteristics.MethodsMale C57BL/6J mice fed with high-fat diets for 8 weeks were established as obese models and subsequently divided into different intervention groups, followed by SE, TE, and their joint interventions for 10 weeks. Body weight and food intake were monitored. Fasting glucose and oral glucose tolerance tests were interspersed during the experiment. After the intervention, the effects on obesity control were assessed based on body composition, liver pathology section, blood lipids and glucose, respiratory exchange ratio (RER), energy expenditure (EE1, EE2, and EE3), inflammatory factors, lipid anabolism enzymes, and gut flora of the obese mice.ResultsAfter continuous gavage intervention, the mice in the intervention groups exhibited lower body weight (lower ~4.93 g, vs. HFD 38.02 g), peri-testicular fat masses (lower ~0.61 g, vs. HFD 1.92 g), and perirenal fat masses (lower ~0.21 g, vs. HFD mice 0.70 g). All interventions prevented diet-induced increases in plasma levels of glucose, adiponectin, leptin, and the inflammatory factors IL-1β and TNF-α. The RER was modified by the interventions, while the rhythm of the RER was not. Blood lipids (total cholesterol, triglycerides, and LDL) decreased and were associated with lower lipid anabolism enzymes. In addition, the SE and TE interventions altered the structure and abundance of specific flora. Different interventions inhibited the growth of different genera positively associated with obesity (Escherichia–Shigella, Helicobacter, etc.) and promoted the growth of Akkermansia and Bacteroides, thus affecting the chronic inflammatory state.ConclusionSE and TE both have synergistic effects on weight control and glucolipid metabolism regulation by improving insulin sensitivity and reducing lipid synthesis-related enzyme expression, whereas the combination of SE and TE (3:1) has a better effect on regulating energy metabolism and inhibiting chronic inflammation. |
| first_indexed | 2024-03-12T13:30:46Z |
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| spelling | doaj.art-ba948b0483de4cdf9844c06615121df32023-08-24T14:01:16ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-08-011010.3389/fnut.2023.12421571242157The effects of Ascophyllum nodosum, Camellia sinensis-leaf extract, and their joint interventions on glycolipid and energy metabolism in obese miceYuhan Xu0Yuhan Xu1Xiuzhen Jia2Xiuzhen Jia3Wei Zhang4Wei Zhang5Qiaoling Xie6Qiaoling Xie7Meizhen Zhu8Meizhen Zhu9Zifu Zhao10Zifu Zhao11Jingyu Hao12Jingyu Hao13Haoqiu Li14Haoqiu Li15Jinrui Du16Jinrui Du17Yan Liu18Yan Liu19Haotian Feng20Haotian Feng21Jian He22Jian He23Hongwei Li24Hongwei Li25State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen, ChinaSchool of Public Health, Xiamen University, Xiamen, ChinaInner Mongolia Dairy Technology Research Institute Co., Ltd., Hohhot, ChinaYili Innovation Center, Inner Mongolia Yili Industrial Group Co., Ltd., Hohhot, ChinaState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen, ChinaSchool of Public Health, Xiamen University, Xiamen, ChinaState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen, ChinaSchool of Public Health, Xiamen University, Xiamen, ChinaState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen, ChinaSchool of Public Health, Xiamen University, Xiamen, ChinaInner Mongolia Dairy Technology Research Institute Co., Ltd., Hohhot, ChinaYili Innovation Center, Inner Mongolia Yili Industrial Group Co., Ltd., Hohhot, ChinaInner Mongolia Dairy Technology Research Institute Co., Ltd., Hohhot, ChinaYili Innovation Center, Inner Mongolia Yili Industrial Group Co., Ltd., Hohhot, ChinaInner Mongolia Dairy Technology Research Institute Co., Ltd., Hohhot, ChinaYili Innovation Center, Inner Mongolia Yili Industrial Group Co., Ltd., Hohhot, ChinaInner Mongolia Dairy Technology Research Institute Co., Ltd., Hohhot, ChinaYili Innovation Center, Inner Mongolia Yili Industrial Group Co., Ltd., Hohhot, ChinaInner Mongolia Dairy Technology Research Institute Co., Ltd., Hohhot, ChinaYili Innovation Center, Inner Mongolia Yili Industrial Group Co., Ltd., Hohhot, ChinaInner Mongolia Dairy Technology Research Institute Co., Ltd., Hohhot, ChinaYili Innovation Center, Inner Mongolia Yili Industrial Group Co., Ltd., Hohhot, ChinaInner Mongolia Dairy Technology Research Institute Co., Ltd., Hohhot, ChinaYili Innovation Center, Inner Mongolia Yili Industrial Group Co., Ltd., Hohhot, ChinaState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen, ChinaSchool of Public Health, Xiamen University, Xiamen, ChinaObjectivesObesity is often associated with glucolipid and/or energy metabolism disorders. Ascophyllum nodosum extract (seaweed extract, SE) and Camellia sinensis-leaf extract (tea extract, TE) have been reported to promote positive metabolic effects through different mechanisms. We investigated the effects of SE and TE on metabolic homeostasis in diet-induced obese mice and discussed their functional characteristics.MethodsMale C57BL/6J mice fed with high-fat diets for 8 weeks were established as obese models and subsequently divided into different intervention groups, followed by SE, TE, and their joint interventions for 10 weeks. Body weight and food intake were monitored. Fasting glucose and oral glucose tolerance tests were interspersed during the experiment. After the intervention, the effects on obesity control were assessed based on body composition, liver pathology section, blood lipids and glucose, respiratory exchange ratio (RER), energy expenditure (EE1, EE2, and EE3), inflammatory factors, lipid anabolism enzymes, and gut flora of the obese mice.ResultsAfter continuous gavage intervention, the mice in the intervention groups exhibited lower body weight (lower ~4.93 g, vs. HFD 38.02 g), peri-testicular fat masses (lower ~0.61 g, vs. HFD 1.92 g), and perirenal fat masses (lower ~0.21 g, vs. HFD mice 0.70 g). All interventions prevented diet-induced increases in plasma levels of glucose, adiponectin, leptin, and the inflammatory factors IL-1β and TNF-α. The RER was modified by the interventions, while the rhythm of the RER was not. Blood lipids (total cholesterol, triglycerides, and LDL) decreased and were associated with lower lipid anabolism enzymes. In addition, the SE and TE interventions altered the structure and abundance of specific flora. Different interventions inhibited the growth of different genera positively associated with obesity (Escherichia–Shigella, Helicobacter, etc.) and promoted the growth of Akkermansia and Bacteroides, thus affecting the chronic inflammatory state.ConclusionSE and TE both have synergistic effects on weight control and glucolipid metabolism regulation by improving insulin sensitivity and reducing lipid synthesis-related enzyme expression, whereas the combination of SE and TE (3:1) has a better effect on regulating energy metabolism and inhibiting chronic inflammation.https://www.frontiersin.org/articles/10.3389/fnut.2023.1242157/fullobesityseaweed extractgreen tea extractrespiratory rhythmintestinal floraglycolipid metabolism |
| spellingShingle | Yuhan Xu Yuhan Xu Xiuzhen Jia Xiuzhen Jia Wei Zhang Wei Zhang Qiaoling Xie Qiaoling Xie Meizhen Zhu Meizhen Zhu Zifu Zhao Zifu Zhao Jingyu Hao Jingyu Hao Haoqiu Li Haoqiu Li Jinrui Du Jinrui Du Yan Liu Yan Liu Haotian Feng Haotian Feng Jian He Jian He Hongwei Li Hongwei Li The effects of Ascophyllum nodosum, Camellia sinensis-leaf extract, and their joint interventions on glycolipid and energy metabolism in obese mice Frontiers in Nutrition obesity seaweed extract green tea extract respiratory rhythm intestinal flora glycolipid metabolism |
| title | The effects of Ascophyllum nodosum, Camellia sinensis-leaf extract, and their joint interventions on glycolipid and energy metabolism in obese mice |
| title_full | The effects of Ascophyllum nodosum, Camellia sinensis-leaf extract, and their joint interventions on glycolipid and energy metabolism in obese mice |
| title_fullStr | The effects of Ascophyllum nodosum, Camellia sinensis-leaf extract, and their joint interventions on glycolipid and energy metabolism in obese mice |
| title_full_unstemmed | The effects of Ascophyllum nodosum, Camellia sinensis-leaf extract, and their joint interventions on glycolipid and energy metabolism in obese mice |
| title_short | The effects of Ascophyllum nodosum, Camellia sinensis-leaf extract, and their joint interventions on glycolipid and energy metabolism in obese mice |
| title_sort | effects of ascophyllum nodosum camellia sinensis leaf extract and their joint interventions on glycolipid and energy metabolism in obese mice |
| topic | obesity seaweed extract green tea extract respiratory rhythm intestinal flora glycolipid metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1242157/full |
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