PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response
The authors describe a functional crosstalk between the p53 network and the integrated stress response through the p53 repressor PPM1D. Inhibition of PPM1D potentiates p53-dependent transactivation and apoptosis via induction of the HRI-eIF2α-ATF4 pathway.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35089-5 |
| _version_ | 1797985574923010048 |
|---|---|
| author | Zdenek Andrysik Kelly D. Sullivan Jeffrey S. Kieft Joaquin M. Espinosa |
| author_facet | Zdenek Andrysik Kelly D. Sullivan Jeffrey S. Kieft Joaquin M. Espinosa |
| author_sort | Zdenek Andrysik |
| collection | DOAJ |
| description | The authors describe a functional crosstalk between the p53 network and the integrated stress response through the p53 repressor PPM1D. Inhibition of PPM1D potentiates p53-dependent transactivation and apoptosis via induction of the HRI-eIF2α-ATF4 pathway. |
| first_indexed | 2024-04-11T07:20:10Z |
| format | Article |
| id | doaj.art-ba96d94410b24d0bac5244271212e7b7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T07:20:10Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ba96d94410b24d0bac5244271212e7b72022-12-22T04:37:48ZengNature PortfolioNature Communications2041-17232022-12-0113111610.1038/s41467-022-35089-5PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress ResponseZdenek Andrysik0Kelly D. Sullivan1Jeffrey S. Kieft2Joaquin M. Espinosa3Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical CampusLinda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical CampusDepartment of Biochemistry and Molecular Genetics and RNA Bioscience Initiative, University of Colorado Anschutz Medical CampusLinda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical CampusThe authors describe a functional crosstalk between the p53 network and the integrated stress response through the p53 repressor PPM1D. Inhibition of PPM1D potentiates p53-dependent transactivation and apoptosis via induction of the HRI-eIF2α-ATF4 pathway.https://doi.org/10.1038/s41467-022-35089-5 |
| spellingShingle | Zdenek Andrysik Kelly D. Sullivan Jeffrey S. Kieft Joaquin M. Espinosa PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response Nature Communications |
| title | PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response |
| title_full | PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response |
| title_fullStr | PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response |
| title_full_unstemmed | PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response |
| title_short | PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response |
| title_sort | ppm1d suppresses p53 dependent transactivation and cell death by inhibiting the integrated stress response |
| url | https://doi.org/10.1038/s41467-022-35089-5 |
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