Different Frequency of Heschl’s Gyrus Duplication Patterns in Neuropsychiatric Disorders: An MRI Study in Bipolar and Major Depressive Disorders
An increased prevalence of duplicated Heschl’s gyrus (HG) has been repeatedly demonstrated in various stages of schizophrenia as a potential neurodevelopmental marker, but it remains unknown whether other neuropsychiatric disorders also exhibit this macroscopic brain feature. The present magnetic re...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2022.917270/full |
| _version_ | 1818546130086002688 |
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| author | Tsutomu Takahashi Tsutomu Takahashi Daiki Sasabayashi Daiki Sasabayashi Murat Yücel Sarah Whittle Valentina Lorenzetti Mark Walterfang Mark Walterfang Mark Walterfang Michio Suzuki Michio Suzuki Christos Pantelis Christos Pantelis Christos Pantelis Gin S. Malhi Gin S. Malhi Nicholas B. Allen |
| author_facet | Tsutomu Takahashi Tsutomu Takahashi Daiki Sasabayashi Daiki Sasabayashi Murat Yücel Sarah Whittle Valentina Lorenzetti Mark Walterfang Mark Walterfang Mark Walterfang Michio Suzuki Michio Suzuki Christos Pantelis Christos Pantelis Christos Pantelis Gin S. Malhi Gin S. Malhi Nicholas B. Allen |
| author_sort | Tsutomu Takahashi |
| collection | DOAJ |
| description | An increased prevalence of duplicated Heschl’s gyrus (HG) has been repeatedly demonstrated in various stages of schizophrenia as a potential neurodevelopmental marker, but it remains unknown whether other neuropsychiatric disorders also exhibit this macroscopic brain feature. The present magnetic resonance imaging study aimed to examine the disease specificity of the established finding of altered HG patterns in schizophrenia by examining independent cohorts of bipolar disorder (BD) and major depressive disorder (MDD). Twenty-six BD patients had a significantly higher prevalence of HG duplication bilaterally compared to 24 age- and sex-matched controls, while their clinical characteristics (e.g., onset age, number of episodes, and medication) did not relate to HG patterns. No significant difference was found for the HG patterns between 56 MDD patients and 33 age- and sex-matched controls, but the patients with a single HG were characterized by more severe depressive/anxiety symptoms compared to those with a duplicated HG. Thus, in keeping with previous findings, the present study suggests that neurodevelopmental pathology associated with gyral formation of the HG during the late gestation period partly overlaps between schizophrenia and BD, but that HG patterns may make a somewhat distinct contribution to the phenomenology of MDD. |
| first_indexed | 2024-12-12T07:49:00Z |
| format | Article |
| id | doaj.art-ba97a696819d4e29be44cfef9ad7d546 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-12T07:49:00Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-ba97a696819d4e29be44cfef9ad7d5462022-12-22T00:32:30ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-06-011610.3389/fnhum.2022.917270917270Different Frequency of Heschl’s Gyrus Duplication Patterns in Neuropsychiatric Disorders: An MRI Study in Bipolar and Major Depressive DisordersTsutomu Takahashi0Tsutomu Takahashi1Daiki Sasabayashi2Daiki Sasabayashi3Murat Yücel4Sarah Whittle5Valentina Lorenzetti6Mark Walterfang7Mark Walterfang8Mark Walterfang9Michio Suzuki10Michio Suzuki11Christos Pantelis12Christos Pantelis13Christos Pantelis14Gin S. Malhi15Gin S. Malhi16Nicholas B. Allen17Department of Neuropsychiatry, School of Medicine, University of Toyama, Toyama, JapanResearch Center for Idling Brain Science, University of Toyama, Toyama, JapanDepartment of Neuropsychiatry, School of Medicine, University of Toyama, Toyama, JapanResearch Center for Idling Brain Science, University of Toyama, Toyama, JapanBrain Park, Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, VIC, AustraliaMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, VIC, AustraliaNeuroscience of Addiction and Mental Health Program, Healthy Brain and Mind Research Centre, School of Psychology, Faculty of Health Sciences, Australian Catholic University, Melbourne, VIC, AustraliaMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, VIC, AustraliaDepartment of Neuropsychiatry, Royal Melbourne Hospital, Melbourne, VIC, AustraliaFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, AustraliaDepartment of Neuropsychiatry, School of Medicine, University of Toyama, Toyama, JapanResearch Center for Idling Brain Science, University of Toyama, Toyama, JapanMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, VIC, AustraliaFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, AustraliaNorth Western Mental Health, Western Hospital Sunshine, St Albans, VIC, AustraliaAcademic Department of Psychiatry, Kolling Institute, Northern Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia0CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, Australia1Department of Psychology, University of Oregon, Eugene, OR, United StatesAn increased prevalence of duplicated Heschl’s gyrus (HG) has been repeatedly demonstrated in various stages of schizophrenia as a potential neurodevelopmental marker, but it remains unknown whether other neuropsychiatric disorders also exhibit this macroscopic brain feature. The present magnetic resonance imaging study aimed to examine the disease specificity of the established finding of altered HG patterns in schizophrenia by examining independent cohorts of bipolar disorder (BD) and major depressive disorder (MDD). Twenty-six BD patients had a significantly higher prevalence of HG duplication bilaterally compared to 24 age- and sex-matched controls, while their clinical characteristics (e.g., onset age, number of episodes, and medication) did not relate to HG patterns. No significant difference was found for the HG patterns between 56 MDD patients and 33 age- and sex-matched controls, but the patients with a single HG were characterized by more severe depressive/anxiety symptoms compared to those with a duplicated HG. Thus, in keeping with previous findings, the present study suggests that neurodevelopmental pathology associated with gyral formation of the HG during the late gestation period partly overlaps between schizophrenia and BD, but that HG patterns may make a somewhat distinct contribution to the phenomenology of MDD.https://www.frontiersin.org/articles/10.3389/fnhum.2022.917270/fullsuperior temporal gyrusHeschl’s gyrusgyrificationmajor depressive disorderbipolar disorder |
| spellingShingle | Tsutomu Takahashi Tsutomu Takahashi Daiki Sasabayashi Daiki Sasabayashi Murat Yücel Sarah Whittle Valentina Lorenzetti Mark Walterfang Mark Walterfang Mark Walterfang Michio Suzuki Michio Suzuki Christos Pantelis Christos Pantelis Christos Pantelis Gin S. Malhi Gin S. Malhi Nicholas B. Allen Different Frequency of Heschl’s Gyrus Duplication Patterns in Neuropsychiatric Disorders: An MRI Study in Bipolar and Major Depressive Disorders Frontiers in Human Neuroscience superior temporal gyrus Heschl’s gyrus gyrification major depressive disorder bipolar disorder |
| title | Different Frequency of Heschl’s Gyrus Duplication Patterns in Neuropsychiatric Disorders: An MRI Study in Bipolar and Major Depressive Disorders |
| title_full | Different Frequency of Heschl’s Gyrus Duplication Patterns in Neuropsychiatric Disorders: An MRI Study in Bipolar and Major Depressive Disorders |
| title_fullStr | Different Frequency of Heschl’s Gyrus Duplication Patterns in Neuropsychiatric Disorders: An MRI Study in Bipolar and Major Depressive Disorders |
| title_full_unstemmed | Different Frequency of Heschl’s Gyrus Duplication Patterns in Neuropsychiatric Disorders: An MRI Study in Bipolar and Major Depressive Disorders |
| title_short | Different Frequency of Heschl’s Gyrus Duplication Patterns in Neuropsychiatric Disorders: An MRI Study in Bipolar and Major Depressive Disorders |
| title_sort | different frequency of heschl s gyrus duplication patterns in neuropsychiatric disorders an mri study in bipolar and major depressive disorders |
| topic | superior temporal gyrus Heschl’s gyrus gyrification major depressive disorder bipolar disorder |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2022.917270/full |
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