Evaluation of aerosol drug delivery with concurrent low- and high-flow nasal oxygen
Question addressed by study Administration of aerosol to patients receiving high-flow nasal oxygen (HFNO) ranges from concurrent aerosol delivery by mouthpiece to aerosol via cannula alone. This study examines the conditions to provide optimal aerosol delivery with low- or high-flow nasal oxygen wit...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2022-10-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/8/4/00220-2022.full |
| _version_ | 1797809454483243008 |
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| author | Barry Murphy Marc Mac Giolla Eain Mary Joyce James B. Fink Ronan MacLoughlin |
| author_facet | Barry Murphy Marc Mac Giolla Eain Mary Joyce James B. Fink Ronan MacLoughlin |
| author_sort | Barry Murphy |
| collection | DOAJ |
| description | Question addressed by study
Administration of aerosol to patients receiving high-flow nasal oxygen (HFNO) ranges from concurrent aerosol delivery by mouthpiece to aerosol via cannula alone. This study examines the conditions to provide optimal aerosol delivery with low- or high-flow nasal oxygen with concurrent mouthpiece or through nasal cannula alone, and the impact on fugitive aerosols.
Materials and methods
A vibrating mesh nebuliser delivered salbutamol via mouthpiece, aerosol holding chamber and nasal cannula to an adult head model simulating relaxed breathing. The mean±sd inhaled dose (%) was assayed from a filter distal to the trachea. Optical particle sizers were used to measure fugitive aerosol concentrations during aerosol delivery.
Results
Concurrent low-flow nasal oxygen (LFNO) and aerosol delivery with a mouthpiece and aerosol holding chamber increased the inhaled dose (%) available, 31.44±1.33% when supplemented with 2 L·min−1 of nasal oxygen. Concurrent HFNO above 30 L·min−1 resulted in a lower inhaled dose (%) compared to aerosol delivered through HFNO alone. The addition of concurrent LFNO or HFNO resulted in no increase in aerosol levels in the test room.
Answer to question posed
Concurrent LFNO with a mouthpiece and aerosol holding chamber is an effective and safe means of aerosol delivery. |
| first_indexed | 2024-03-13T06:53:03Z |
| format | Article |
| id | doaj.art-ba98fcf164ce491da5cc33967a72df67 |
| institution | Directory Open Access Journal |
| issn | 2312-0541 |
| language | English |
| last_indexed | 2024-03-13T06:53:03Z |
| publishDate | 2022-10-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj.art-ba98fcf164ce491da5cc33967a72df672023-06-07T13:30:36ZengEuropean Respiratory SocietyERJ Open Research2312-05412022-10-018410.1183/23120541.00220-202200220-2022Evaluation of aerosol drug delivery with concurrent low- and high-flow nasal oxygenBarry Murphy0Marc Mac Giolla Eain1Mary Joyce2James B. Fink3Ronan MacLoughlin4 Research and Development, Science & Emerging Technologies, Aerogen Limited, Galway, Ireland Research and Development, Science & Emerging Technologies, Aerogen Limited, Galway, Ireland Research and Development, Science & Emerging Technologies, Aerogen Limited, Galway, Ireland Aerogen Pharma Corporation, San Mateo, CA, USA Research and Development, Science & Emerging Technologies, Aerogen Limited, Galway, Ireland Question addressed by study Administration of aerosol to patients receiving high-flow nasal oxygen (HFNO) ranges from concurrent aerosol delivery by mouthpiece to aerosol via cannula alone. This study examines the conditions to provide optimal aerosol delivery with low- or high-flow nasal oxygen with concurrent mouthpiece or through nasal cannula alone, and the impact on fugitive aerosols. Materials and methods A vibrating mesh nebuliser delivered salbutamol via mouthpiece, aerosol holding chamber and nasal cannula to an adult head model simulating relaxed breathing. The mean±sd inhaled dose (%) was assayed from a filter distal to the trachea. Optical particle sizers were used to measure fugitive aerosol concentrations during aerosol delivery. Results Concurrent low-flow nasal oxygen (LFNO) and aerosol delivery with a mouthpiece and aerosol holding chamber increased the inhaled dose (%) available, 31.44±1.33% when supplemented with 2 L·min−1 of nasal oxygen. Concurrent HFNO above 30 L·min−1 resulted in a lower inhaled dose (%) compared to aerosol delivered through HFNO alone. The addition of concurrent LFNO or HFNO resulted in no increase in aerosol levels in the test room. Answer to question posed Concurrent LFNO with a mouthpiece and aerosol holding chamber is an effective and safe means of aerosol delivery.http://openres.ersjournals.com/content/8/4/00220-2022.full |
| spellingShingle | Barry Murphy Marc Mac Giolla Eain Mary Joyce James B. Fink Ronan MacLoughlin Evaluation of aerosol drug delivery with concurrent low- and high-flow nasal oxygen ERJ Open Research |
| title | Evaluation of aerosol drug delivery with concurrent low- and high-flow nasal oxygen |
| title_full | Evaluation of aerosol drug delivery with concurrent low- and high-flow nasal oxygen |
| title_fullStr | Evaluation of aerosol drug delivery with concurrent low- and high-flow nasal oxygen |
| title_full_unstemmed | Evaluation of aerosol drug delivery with concurrent low- and high-flow nasal oxygen |
| title_short | Evaluation of aerosol drug delivery with concurrent low- and high-flow nasal oxygen |
| title_sort | evaluation of aerosol drug delivery with concurrent low and high flow nasal oxygen |
| url | http://openres.ersjournals.com/content/8/4/00220-2022.full |
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