Slow clinical improvement after treatment initiation in Leishmania/HIV coinfected patients
INTRODUCTION: In Brazil there is a large area of overlap of visceral leishmaniasis (VL) and HIV infection, which favored a increased incidence of coinfection Leishmania/HIV. METHODS: This study evaluated 65 consecutive patients with VL and their clinical response to treatment in two health care sett...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2012-04-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000200001&lng=en&tlng=en |
| _version_ | 1818232597232222208 |
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| author | Guenael Freire de Souza Fernando Biscione Dirceu Bartolomeu Greco Ana Rabello |
| author_facet | Guenael Freire de Souza Fernando Biscione Dirceu Bartolomeu Greco Ana Rabello |
| author_sort | Guenael Freire de Souza |
| collection | DOAJ |
| description | INTRODUCTION: In Brazil there is a large area of overlap of visceral leishmaniasis (VL) and HIV infection, which favored a increased incidence of coinfection Leishmania/HIV. METHODS: This study evaluated 65 consecutive patients with VL and their clinical response to treatment in two health care settings in Belo Horizonte, Brazil. RESULTS: At baseline, the clinical picture was similar between both groups, although diarrhea and peripheral lymphadenomegaly were more frequent in HIV-infected subjects. HIV-positive patients had lower median blood lymphocyte counts (686/mm³ versus 948/mm³p = 0.004) and lower values of alanine aminotransferase (ALT) (48IU/L versus 75.6IU/L p = 0.016) than HIV-negative patients. HIV-positive status (hazard ratio = 0.423, p = 0.023) and anemia (HR = 0.205, p = 0.002) were independent negative predictors of complete clinical response following antileishmanial treatment initiation. CONCLUSIONS: This study reinforces that all patients with VL should be tested for HIV infection, regardless of their clinical picture. This practice would allow early recognition of coinfection with initiation of antiretroviral therapy and, possibly, reduction in treatment failure. |
| first_indexed | 2024-12-12T11:08:49Z |
| format | Article |
| id | doaj.art-ba9dde46554b456b86912d065e81430f |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-12-12T11:08:49Z |
| publishDate | 2012-04-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-ba9dde46554b456b86912d065e81430f2022-12-22T00:26:21ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492012-04-0145214715010.1590/S0037-86822012000200001S0037-86822012000200001Slow clinical improvement after treatment initiation in Leishmania/HIV coinfected patientsGuenael Freire de Souza0Fernando Biscione1Dirceu Bartolomeu Greco2Ana Rabello3Universidade Federal de Minas GeraisUniversidade Federal de Minas GeraisUniversidade Federal de Minas GeraisFundação Oswaldo CruzINTRODUCTION: In Brazil there is a large area of overlap of visceral leishmaniasis (VL) and HIV infection, which favored a increased incidence of coinfection Leishmania/HIV. METHODS: This study evaluated 65 consecutive patients with VL and their clinical response to treatment in two health care settings in Belo Horizonte, Brazil. RESULTS: At baseline, the clinical picture was similar between both groups, although diarrhea and peripheral lymphadenomegaly were more frequent in HIV-infected subjects. HIV-positive patients had lower median blood lymphocyte counts (686/mm³ versus 948/mm³p = 0.004) and lower values of alanine aminotransferase (ALT) (48IU/L versus 75.6IU/L p = 0.016) than HIV-negative patients. HIV-positive status (hazard ratio = 0.423, p = 0.023) and anemia (HR = 0.205, p = 0.002) were independent negative predictors of complete clinical response following antileishmanial treatment initiation. CONCLUSIONS: This study reinforces that all patients with VL should be tested for HIV infection, regardless of their clinical picture. This practice would allow early recognition of coinfection with initiation of antiretroviral therapy and, possibly, reduction in treatment failure.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000200001&lng=en&tlng=enLeishmaniose visceralHIVCo-infecçãoTratamento |
| spellingShingle | Guenael Freire de Souza Fernando Biscione Dirceu Bartolomeu Greco Ana Rabello Slow clinical improvement after treatment initiation in Leishmania/HIV coinfected patients Revista da Sociedade Brasileira de Medicina Tropical Leishmaniose visceral HIV Co-infecção Tratamento |
| title | Slow clinical improvement after treatment initiation in Leishmania/HIV coinfected patients |
| title_full | Slow clinical improvement after treatment initiation in Leishmania/HIV coinfected patients |
| title_fullStr | Slow clinical improvement after treatment initiation in Leishmania/HIV coinfected patients |
| title_full_unstemmed | Slow clinical improvement after treatment initiation in Leishmania/HIV coinfected patients |
| title_short | Slow clinical improvement after treatment initiation in Leishmania/HIV coinfected patients |
| title_sort | slow clinical improvement after treatment initiation in leishmania hiv coinfected patients |
| topic | Leishmaniose visceral HIV Co-infecção Tratamento |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000200001&lng=en&tlng=en |
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