Oral N - Acetyl Cysteine for Meconium Ileus of Preterm Infants
Objective: Meconium ileus of preterm infant is a kind of intestinal obstruction. There is no standard medical treatment of meconium ileus of preterm infant. Study Design: During the study period, preterm infants under 1250 g and have clinical signs of meconium obstruction were retrospectively incl...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Medical Network
2019-12-01
|
| Series: | Gynecology Obstetrics & Reproductive Medicine |
| Subjects: | |
| Online Access: | http://gorm.com.tr/index.php/GORM/article/view/930 |
| _version_ | 1797912602065502208 |
|---|---|
| author | Gulsum Kadioglu Simsek Sema Arayici Mehmet Buyuktiryaki Nilufer Okur Gozde Kanmaz Kutman Serife Suna Oguz |
| author_facet | Gulsum Kadioglu Simsek Sema Arayici Mehmet Buyuktiryaki Nilufer Okur Gozde Kanmaz Kutman Serife Suna Oguz |
| author_sort | Gulsum Kadioglu Simsek |
| collection | DOAJ |
| description | Objective: Meconium ileus of preterm infant is a kind of intestinal obstruction. There is no standard medical treatment of meconium ileus of preterm infant.
Study Design: During the study period, preterm infants under 1250 g and have clinical signs of meconium obstruction were retrospectively included in the study. In the first two days, rectal saline and metoclopramide started and if not respond these infants assigned to receive oral or rectal n-acetyl cysteine and control group remained to receive a saline enema.
Results: One hundred and twenty-one infants were included in the study. Thirty-four of them received oral n-acetyl cysteine (group 1) and fifty-two had treated with rectal n-acetyl cysteine (group 2), thirty-five of them served as a control group (group 3). The mean gestational ages were 28, 28, 27 weeks and birthweights were 942, 1010, 965 grams for group 1 & 2 & 3 respectively. There was a difference between groups for reaching full enteral feedings (13 ±2, 13 ±3, 15±3, group 1 & 2 & 3 respectively, p=0.001).
Conclusion: According to this study, it can be stated that orally administered n-acetyl cysteine is tolerable and as effective as rectal n-acetyl cysteine when used for MIPI. |
| first_indexed | 2024-04-10T11:58:29Z |
| format | Article |
| id | doaj.art-ba9e3dba93ad43cab9b97e9fb77f30d8 |
| institution | Directory Open Access Journal |
| issn | 1300-4751 |
| language | English |
| last_indexed | 2024-04-10T11:58:29Z |
| publishDate | 2019-12-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj.art-ba9e3dba93ad43cab9b97e9fb77f30d82023-02-15T16:16:44ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512019-12-0125316917310.21613/GORM.2019.930681Oral N - Acetyl Cysteine for Meconium Ileus of Preterm InfantsGulsum Kadioglu Simsek0Sema Arayici1Mehmet Buyuktiryaki2Nilufer Okur3Gozde Kanmaz Kutman4Serife Suna Oguz5Zekai Tahir Burak YenidoğanZekai Tahir Burak NeonatologyZekai Tahir Burak HastanesiZekai Tahir NeonatologyZekai Tahir NeonatologyZekai Tahir Burak NeonatologyObjective: Meconium ileus of preterm infant is a kind of intestinal obstruction. There is no standard medical treatment of meconium ileus of preterm infant. Study Design: During the study period, preterm infants under 1250 g and have clinical signs of meconium obstruction were retrospectively included in the study. In the first two days, rectal saline and metoclopramide started and if not respond these infants assigned to receive oral or rectal n-acetyl cysteine and control group remained to receive a saline enema. Results: One hundred and twenty-one infants were included in the study. Thirty-four of them received oral n-acetyl cysteine (group 1) and fifty-two had treated with rectal n-acetyl cysteine (group 2), thirty-five of them served as a control group (group 3). The mean gestational ages were 28, 28, 27 weeks and birthweights were 942, 1010, 965 grams for group 1 & 2 & 3 respectively. There was a difference between groups for reaching full enteral feedings (13 ±2, 13 ±3, 15±3, group 1 & 2 & 3 respectively, p=0.001). Conclusion: According to this study, it can be stated that orally administered n-acetyl cysteine is tolerable and as effective as rectal n-acetyl cysteine when used for MIPI.http://gorm.com.tr/index.php/GORM/article/view/930preterm infant, meconium plug, meconium ileus, n-acetyl cystein |
| spellingShingle | Gulsum Kadioglu Simsek Sema Arayici Mehmet Buyuktiryaki Nilufer Okur Gozde Kanmaz Kutman Serife Suna Oguz Oral N - Acetyl Cysteine for Meconium Ileus of Preterm Infants Gynecology Obstetrics & Reproductive Medicine preterm infant, meconium plug, meconium ileus, n-acetyl cystein |
| title | Oral N - Acetyl Cysteine for Meconium Ileus of Preterm Infants |
| title_full | Oral N - Acetyl Cysteine for Meconium Ileus of Preterm Infants |
| title_fullStr | Oral N - Acetyl Cysteine for Meconium Ileus of Preterm Infants |
| title_full_unstemmed | Oral N - Acetyl Cysteine for Meconium Ileus of Preterm Infants |
| title_short | Oral N - Acetyl Cysteine for Meconium Ileus of Preterm Infants |
| title_sort | oral n acetyl cysteine for meconium ileus of preterm infants |
| topic | preterm infant, meconium plug, meconium ileus, n-acetyl cystein |
| url | http://gorm.com.tr/index.php/GORM/article/view/930 |
| work_keys_str_mv | AT gulsumkadioglusimsek oralnacetylcysteineformeconiumileusofpreterminfants AT semaarayici oralnacetylcysteineformeconiumileusofpreterminfants AT mehmetbuyuktiryaki oralnacetylcysteineformeconiumileusofpreterminfants AT niluferokur oralnacetylcysteineformeconiumileusofpreterminfants AT gozdekanmazkutman oralnacetylcysteineformeconiumileusofpreterminfants AT serifesunaoguz oralnacetylcysteineformeconiumileusofpreterminfants |