Oral Lesions in Pediatric Subjects: SARS-CoV-2 Infection and COVID-19 Vaccination
A plethora of systemic manifestations of COVID-19 and adverse reactions to COVID-19 vaccines have been described in pediatric subjects. Therefore, the present systematic review primarily aimed to assess the prevalence and macro-microscopic features of oral lesions following SARS-CoV-2 infection, gra...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/18/8995 |
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| author | Federica Di Spirito Mario Caggiano Maria Pia Di Palo Maria Contaldo Francesco D’Ambrosio Stefano Martina Alessandra Amato |
| author_facet | Federica Di Spirito Mario Caggiano Maria Pia Di Palo Maria Contaldo Francesco D’Ambrosio Stefano Martina Alessandra Amato |
| author_sort | Federica Di Spirito |
| collection | DOAJ |
| description | A plethora of systemic manifestations of COVID-19 and adverse reactions to COVID-19 vaccines have been described in pediatric subjects. Therefore, the present systematic review primarily aimed to assess the prevalence and macro-microscopic features of oral lesions following SARS-CoV-2 infection, grading primary oral lesions based on COVID-19 forms, in pediatric subjects. The secondary aim was to evaluate the epidemiology, clinical appearance, and histopathology of oral lesions following the WHO Emergency Use Listing approved and EMA authorized vaccines, in relation to cases and vaccine characteristics. The study protocol was compliant with the PRISMA statement and registered on PROSPERO (CRD42022351821). Case reports, case series, and observational studies were electronically searched till 27 July 2022, on MEDLINE/PubMed, Scopus, and Cochrane library databases, and the PROSPERO register. Data from nine studies describing oral lesions following viral infection and two records reporting oral lesions following vaccine administration, evaluated through the ROBINS-I tool for quality, were independently extracted and qualitatively synthesized, resulting in scarce, jeopardized, and incomplete findings. Since most of the rare lesions recorded were a part of broad-spectrum systemic disorders and syndromes and, thus. undetailed or nonspecific, further studies should assess oral lesions following SARS-CoV-2 infection and vaccination in pediatric subjects, considering novel viral variants and newly developing vaccines. |
| first_indexed | 2024-03-10T00:51:16Z |
| format | Article |
| id | doaj.art-baa05aa85def44bb9e8ecc25116b14db |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T00:51:16Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-baa05aa85def44bb9e8ecc25116b14db2023-11-23T14:51:24ZengMDPI AGApplied Sciences2076-34172022-09-011218899510.3390/app12188995Oral Lesions in Pediatric Subjects: SARS-CoV-2 Infection and COVID-19 VaccinationFederica Di Spirito0Mario Caggiano1Maria Pia Di Palo2Maria Contaldo3Francesco D’Ambrosio4Stefano Martina5Alessandra Amato6Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, ItalyDepartment of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, ItalyDepartment of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, ItalyMultidisciplinary Department of Medical-Surgical and Odontostomatological Specialities, University of Campania “Luigi Vanvitelli”, 81100 Naples, ItalyDepartment of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, ItalyDepartment of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, ItalyDepartment of Neuroscience, Reproductive Science and Dentistry, University of Naples Federico II, 80138 Naples, ItalyA plethora of systemic manifestations of COVID-19 and adverse reactions to COVID-19 vaccines have been described in pediatric subjects. Therefore, the present systematic review primarily aimed to assess the prevalence and macro-microscopic features of oral lesions following SARS-CoV-2 infection, grading primary oral lesions based on COVID-19 forms, in pediatric subjects. The secondary aim was to evaluate the epidemiology, clinical appearance, and histopathology of oral lesions following the WHO Emergency Use Listing approved and EMA authorized vaccines, in relation to cases and vaccine characteristics. The study protocol was compliant with the PRISMA statement and registered on PROSPERO (CRD42022351821). Case reports, case series, and observational studies were electronically searched till 27 July 2022, on MEDLINE/PubMed, Scopus, and Cochrane library databases, and the PROSPERO register. Data from nine studies describing oral lesions following viral infection and two records reporting oral lesions following vaccine administration, evaluated through the ROBINS-I tool for quality, were independently extracted and qualitatively synthesized, resulting in scarce, jeopardized, and incomplete findings. Since most of the rare lesions recorded were a part of broad-spectrum systemic disorders and syndromes and, thus. undetailed or nonspecific, further studies should assess oral lesions following SARS-CoV-2 infection and vaccination in pediatric subjects, considering novel viral variants and newly developing vaccines.https://www.mdpi.com/2076-3417/12/18/8995COVID-19SARS-CoV-2Coronavirus disease 2019novel coronavirusoral lesionsoral manifestations |
| spellingShingle | Federica Di Spirito Mario Caggiano Maria Pia Di Palo Maria Contaldo Francesco D’Ambrosio Stefano Martina Alessandra Amato Oral Lesions in Pediatric Subjects: SARS-CoV-2 Infection and COVID-19 Vaccination Applied Sciences COVID-19 SARS-CoV-2 Coronavirus disease 2019 novel coronavirus oral lesions oral manifestations |
| title | Oral Lesions in Pediatric Subjects: SARS-CoV-2 Infection and COVID-19 Vaccination |
| title_full | Oral Lesions in Pediatric Subjects: SARS-CoV-2 Infection and COVID-19 Vaccination |
| title_fullStr | Oral Lesions in Pediatric Subjects: SARS-CoV-2 Infection and COVID-19 Vaccination |
| title_full_unstemmed | Oral Lesions in Pediatric Subjects: SARS-CoV-2 Infection and COVID-19 Vaccination |
| title_short | Oral Lesions in Pediatric Subjects: SARS-CoV-2 Infection and COVID-19 Vaccination |
| title_sort | oral lesions in pediatric subjects sars cov 2 infection and covid 19 vaccination |
| topic | COVID-19 SARS-CoV-2 Coronavirus disease 2019 novel coronavirus oral lesions oral manifestations |
| url | https://www.mdpi.com/2076-3417/12/18/8995 |
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