Evaluation of N-alkyl isatins and indoles as acetylcholinesterase and butyrylcholinesterase inhibitors

Evaluation of N-alkyl isatins and indoles as acetylcholinesterase and butyrylcholinesterase inhibitors

AbstractTwo series of N-alkyl isatins and N-alkyl indoles varying in size of the alkyl group were synthesised and evaluated for inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Among the N-alkyl isatins 4a-j, the addition of the N-alkyl group improved inhibition potency to...

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Bibliographic Details
Main Authors: Kaitlyn N. Alcorn, Isabelle A. Oberhauser, Matthew D. Politeski, Todd J. Eckroat
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Isatin
indole
acetylcholinesterase
butyrylcholinesterase
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2023.2286935

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