Suppression of a Subset of Interferon-Induced Genes by Human Papillomavirus Type 16 E7 via a Cyclin Dependent Kinase 8-Dependent Mechanism

Suppression of a Subset of Interferon-Induced Genes by Human Papillomavirus Type 16 E7 via a Cyclin Dependent Kinase 8-Dependent Mechanism

Persistent infection by human papillomaviruses (HPVs), small, double-stranded DNA viruses that infect keratinocytes of the squamous epithelia, can lead to the development of cervical and other cancers. The viral oncoprotein E7 contributes to viral persistence in part by regulating host gene expressi...

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Bibliographic Details
Main Authors: Sadie Rice, Seong-man Kim, Cynthia Rodriguez, William Songock, Gaurav Raikhy, Rebecca Lopez, Lauren Henderson, Arjun Yusufji, Jason Bodily
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Viruses
Subjects:
stat1
ifn signaling
interferon-stimulated genes
transcription
mediator kinase cdk8
papillomaviruses
oncoprotein e7
Online Access:https://www.mdpi.com/1999-4915/12/3/311

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