Advances in our understanding of nematode ion channels as potential anthelmintic targets
Ion channels are specialized multimeric proteins that underlie cell excitability. These channels integrate with a variety of neuromuscular and biological functions. In nematodes, the physiological behaviors including locomotion, navigation, feeding and reproduction, are regulated by these protein en...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | International Journal for Parasitology: Drugs and Drug Resistance |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211320721000543 |
| _version_ | 1819159004165701632 |
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| author | Shivani Choudhary Sudhanva S. Kashyap Richard J. Martin Alan P. Robertson |
| author_facet | Shivani Choudhary Sudhanva S. Kashyap Richard J. Martin Alan P. Robertson |
| author_sort | Shivani Choudhary |
| collection | DOAJ |
| description | Ion channels are specialized multimeric proteins that underlie cell excitability. These channels integrate with a variety of neuromuscular and biological functions. In nematodes, the physiological behaviors including locomotion, navigation, feeding and reproduction, are regulated by these protein entities. Majority of the antinematodal chemotherapeutics target the ion channels to disrupt essential biological functions. Here, we have summarized current advances in our understanding of nematode ion channel pharmacology. We review cys-loop ligand gated ion channels (LGICs), including nicotinic acetylcholine receptors (nAChRs), acetylcholine-chloride gated ion channels (ACCs), glutamate-gated chloride channels (GluCls), and GABA (γ-aminobutyric acid) receptors, and other ionotropic receptors (transient receptor potential (TRP) channels and potassium ion channels). We have provided an update on the pharmacological properties of these channels from various nematodes. This article catalogs the differences in ion channel composition and resulting pharmacology in the phylum Nematoda. This diversity in ion channel subunit repertoire and pharmacology emphasizes the importance of pursuing species-specific drug target research. In this review, we have provided an overview of recent advances in techniques and functional assays available for screening ion channel properties and their application. |
| first_indexed | 2024-12-22T16:33:39Z |
| format | Article |
| id | doaj.art-baa7d2d665ad40c0a85f8cd8528a4a91 |
| institution | Directory Open Access Journal |
| issn | 2211-3207 |
| language | English |
| last_indexed | 2024-12-22T16:33:39Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal for Parasitology: Drugs and Drug Resistance |
| spelling | doaj.art-baa7d2d665ad40c0a85f8cd8528a4a912022-12-21T18:20:01ZengElsevierInternational Journal for Parasitology: Drugs and Drug Resistance2211-32072022-04-01185286Advances in our understanding of nematode ion channels as potential anthelmintic targetsShivani Choudhary0Sudhanva S. Kashyap1Richard J. Martin2Alan P. Robertson3Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USADepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USADepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USACorresponding author.; Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USAIon channels are specialized multimeric proteins that underlie cell excitability. These channels integrate with a variety of neuromuscular and biological functions. In nematodes, the physiological behaviors including locomotion, navigation, feeding and reproduction, are regulated by these protein entities. Majority of the antinematodal chemotherapeutics target the ion channels to disrupt essential biological functions. Here, we have summarized current advances in our understanding of nematode ion channel pharmacology. We review cys-loop ligand gated ion channels (LGICs), including nicotinic acetylcholine receptors (nAChRs), acetylcholine-chloride gated ion channels (ACCs), glutamate-gated chloride channels (GluCls), and GABA (γ-aminobutyric acid) receptors, and other ionotropic receptors (transient receptor potential (TRP) channels and potassium ion channels). We have provided an update on the pharmacological properties of these channels from various nematodes. This article catalogs the differences in ion channel composition and resulting pharmacology in the phylum Nematoda. This diversity in ion channel subunit repertoire and pharmacology emphasizes the importance of pursuing species-specific drug target research. In this review, we have provided an overview of recent advances in techniques and functional assays available for screening ion channel properties and their application.http://www.sciencedirect.com/science/article/pii/S2211320721000543Ion channelsNicotinic acetylcholine receptorsGlutamate-gated chloride channelGABA receptorsTRP channelsPatch clamp |
| spellingShingle | Shivani Choudhary Sudhanva S. Kashyap Richard J. Martin Alan P. Robertson Advances in our understanding of nematode ion channels as potential anthelmintic targets International Journal for Parasitology: Drugs and Drug Resistance Ion channels Nicotinic acetylcholine receptors Glutamate-gated chloride channel GABA receptors TRP channels Patch clamp |
| title | Advances in our understanding of nematode ion channels as potential anthelmintic targets |
| title_full | Advances in our understanding of nematode ion channels as potential anthelmintic targets |
| title_fullStr | Advances in our understanding of nematode ion channels as potential anthelmintic targets |
| title_full_unstemmed | Advances in our understanding of nematode ion channels as potential anthelmintic targets |
| title_short | Advances in our understanding of nematode ion channels as potential anthelmintic targets |
| title_sort | advances in our understanding of nematode ion channels as potential anthelmintic targets |
| topic | Ion channels Nicotinic acetylcholine receptors Glutamate-gated chloride channel GABA receptors TRP channels Patch clamp |
| url | http://www.sciencedirect.com/science/article/pii/S2211320721000543 |
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