Landscapes of gut microbiome and bile acid signatures and their interaction in HBV-associated acute-on-chronic liver failure

Landscapes of gut microbiome and bile acid signatures and their interaction in HBV-associated acute-on-chronic liver failure

IntroductionSubmassive hepatic necrosis (SMHN, defined as necrosis of 15–90% of the entire liver on explant) is a likely characteristic pathological feature of ACLF in patients with hepatitis B cirrhosis. We aimed to comprehensively explore microbiome and bile acids patterns across enterhepatic circ...

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Bibliographic Details
Main Authors: Zhiwei Bao, Runan Wei, Xiaoping Zheng, Ting Zhang, Yunjiao Bi, Sijia Shen, Pengfei Zou, Junjie Zhang, Huadong Yan, Ming D. Li, Zhongli Yang, Hainv Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Microbiology
Subjects:
acute-on-chronic liver failure
submassive hepatic necrosis
acute decompensation
bile acids (BAs)
gut microbiome
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1185993/full

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