Chemokine switch regulated by TGF-β1 in cancer-associated fibroblast subsets determines the efficacy of chemo-immunotherapy

Chemokine switch regulated by TGF-β1 in cancer-associated fibroblast subsets determines the efficacy of chemo-immunotherapy

Combining immunogenic cell death-inducing chemotherapies and PD-1 blockade can generate remarkable tumor responses. It is now well established that TGF-β1 signaling is a major component of treatment resistance and contributes to the cancer-related immunosuppressive microenvironment. However, whether...

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Bibliographic Details
Main Authors: Angélique Vienot, Jean-René Pallandre, Elodie Renaude, Julien Viot, Adeline Bouard, Laurie Spehner, Marie Kroemer, Syrine Abdeljaoued, Bas van der Woning, Hans de Haard, Romain Loyon, Eric Hervouet, Paul Peixoto, Christophe Borg
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
fibroblast
TGF-β
chemo-immunotherapy
chemokine
cancer
microenvironment
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2144669

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