Formation and Transformation Behavior of Sodium Dehydroacetate Hydrates
The effect of various controlling factors on the polymorphic outcome of sodium dehydroacetate crystallization was investigated in this study. Cooling crystallization experiments of sodium dehydroacetate in water were conducted at different concentrations. The results revealed that the rate of supers...
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MDPI AG
2016-04-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/4/458 |
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| author | Xia Zhang Chuang Xie Yaohui Huang Baohong Hou Ying Bao Junbo Gong Qiuxiang Yin Sohrab Rohani |
| author_facet | Xia Zhang Chuang Xie Yaohui Huang Baohong Hou Ying Bao Junbo Gong Qiuxiang Yin Sohrab Rohani |
| author_sort | Xia Zhang |
| collection | DOAJ |
| description | The effect of various controlling factors on the polymorphic outcome of sodium dehydroacetate crystallization was investigated in this study. Cooling crystallization experiments of sodium dehydroacetate in water were conducted at different concentrations. The results revealed that the rate of supersaturation generation played a key role in the formation of the hydrates. At a high supersaturation generation rate, a new sodium dehydroacetate dihydrate needle form was obtained; on the contrary, a sodium dehydroacetate plate monohydrate was formed at a low supersaturation generation rate. Furthermore, the characterization and transformation behavior of these two hydrated forms were investigated with the combined use of microscopy, powder X-ray diffraction (PXRD), Raman spectroscopy, Fourier transform infrared (FTIR), thermal gravimetric analysis (TGA), scanning electron microscopy (SEM) and dynamic vapor sorption (DVS). It was found that the new needle crystals were dihydrated and hollow, and they eventually transformed into sodium dehydroacetate monohydrate. In addition, the mechanism of formation of sodium dehydroacetate hydrates was discussed, and a process growth model of hollow crystals in cooling crystallization was proposed. |
| first_indexed | 2024-12-10T14:13:41Z |
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| id | doaj.art-baaa1e58788042a1a0e15dc0218c517d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-10T14:13:41Z |
| publishDate | 2016-04-01 |
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| series | Molecules |
| spelling | doaj.art-baaa1e58788042a1a0e15dc0218c517d2022-12-22T01:45:25ZengMDPI AGMolecules1420-30492016-04-0121445810.3390/molecules21040458molecules21040458Formation and Transformation Behavior of Sodium Dehydroacetate HydratesXia Zhang0Chuang Xie1Yaohui Huang2Baohong Hou3Ying Bao4Junbo Gong5Qiuxiang Yin6Sohrab Rohani7State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin 300072, ChinaState Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin 300072, ChinaState Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin 300072, ChinaState Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin 300072, ChinaState Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin 300072, ChinaState Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin 300072, ChinaState Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin 300072, ChinaDepartment of Chemical and Biochemical Engineering, The University of Western Ontario, London, ON N6A 5B9, CanadaThe effect of various controlling factors on the polymorphic outcome of sodium dehydroacetate crystallization was investigated in this study. Cooling crystallization experiments of sodium dehydroacetate in water were conducted at different concentrations. The results revealed that the rate of supersaturation generation played a key role in the formation of the hydrates. At a high supersaturation generation rate, a new sodium dehydroacetate dihydrate needle form was obtained; on the contrary, a sodium dehydroacetate plate monohydrate was formed at a low supersaturation generation rate. Furthermore, the characterization and transformation behavior of these two hydrated forms were investigated with the combined use of microscopy, powder X-ray diffraction (PXRD), Raman spectroscopy, Fourier transform infrared (FTIR), thermal gravimetric analysis (TGA), scanning electron microscopy (SEM) and dynamic vapor sorption (DVS). It was found that the new needle crystals were dihydrated and hollow, and they eventually transformed into sodium dehydroacetate monohydrate. In addition, the mechanism of formation of sodium dehydroacetate hydrates was discussed, and a process growth model of hollow crystals in cooling crystallization was proposed.http://www.mdpi.com/1420-3049/21/4/458sodium dehydroacetatemonohydratedihydratecooling crystallizationhollow crystalformation mechanismtransformation |
| spellingShingle | Xia Zhang Chuang Xie Yaohui Huang Baohong Hou Ying Bao Junbo Gong Qiuxiang Yin Sohrab Rohani Formation and Transformation Behavior of Sodium Dehydroacetate Hydrates Molecules sodium dehydroacetate monohydrate dihydrate cooling crystallization hollow crystal formation mechanism transformation |
| title | Formation and Transformation Behavior of Sodium Dehydroacetate Hydrates |
| title_full | Formation and Transformation Behavior of Sodium Dehydroacetate Hydrates |
| title_fullStr | Formation and Transformation Behavior of Sodium Dehydroacetate Hydrates |
| title_full_unstemmed | Formation and Transformation Behavior of Sodium Dehydroacetate Hydrates |
| title_short | Formation and Transformation Behavior of Sodium Dehydroacetate Hydrates |
| title_sort | formation and transformation behavior of sodium dehydroacetate hydrates |
| topic | sodium dehydroacetate monohydrate dihydrate cooling crystallization hollow crystal formation mechanism transformation |
| url | http://www.mdpi.com/1420-3049/21/4/458 |
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