Age-Related Decrease in Male Extra-Striatal Adenosine A1 Receptors Measured Using11C-MPDX PET

Age-Related Decrease in Male Extra-Striatal Adenosine A1 Receptors Measured Using11C-MPDX PET

Adenosine A1 receptors (A1Rs) are widely distributed throughout the entire human brain, while adenosine A2A receptors (A2ARs) are present in dopamine-rich areas of the brain, such as the basal ganglia. A past study using autoradiography reported a reduced binding ability of A1R in the striatum of ol...

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Bibliographic Details
Main Authors: Masahiro Mishina, Yuichi Kimura, Muneyuki Sakata, Kenji Ishii, Keiichi Oda, Jun Toyohara, Kazumi Kimura, Kiichi Ishiwata
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Pharmacology
Subjects:
adenosine A1 receptor
aging
positron emission tomography
humans
cerebral cortex
thalamus
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00903/full

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