Characterization of Non-Ischemic Dilated Cardiomyopathy in a Native Tanzanian Cohort: MOYO Study
Background: Non-ischemic dilated cardiomyopathy (NIDCM) is a common cause of heart failure with progressive tendency. The disease occurs in one in every 2,500 individuals in the developed world, with high morbidity and mortality. However, detailed data on the role of NIDCM in heart failure in Tanzan...
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| Format: | Article |
| Language: | English |
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Ubiquity Press
2024-02-01
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| Series: | Global Heart |
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| Online Access: | https://account.globalheartjournal.com/index.php/up-j-gh/article/view/1298 |
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| author | Lulu Said Fundikira Pilly Chillo Mohamed Z. Alimohamed Henry Mayala Engerasiya Kifai Geofrey M. Aloyce Appolinary Kamuhabwa Gideon Kwesigabo Linda W. van Laake Folkert W. Asselbergs |
| author_facet | Lulu Said Fundikira Pilly Chillo Mohamed Z. Alimohamed Henry Mayala Engerasiya Kifai Geofrey M. Aloyce Appolinary Kamuhabwa Gideon Kwesigabo Linda W. van Laake Folkert W. Asselbergs |
| author_sort | Lulu Said Fundikira |
| collection | DOAJ |
| description | Background: Non-ischemic dilated cardiomyopathy (NIDCM) is a common cause of heart failure with progressive tendency. The disease occurs in one in every 2,500 individuals in the developed world, with high morbidity and mortality. However, detailed data on the role of NIDCM in heart failure in Tanzania is lacking. Aim: To characterize NIDCM in a Tanzanian cohort with respect to demographics, clinical profile, imaging findings and management. Methods: Characterization of non-ischemic dilated cardioMyOpathY in a native Tanzanian cOhort (MOYO) is a prospective cohort study of NIDCM patients seen at the Jakaya Kikwete Cardiac Institute. Patients aged ≥18 years with a clinical diagnosis of heart failure, an ejection fraction of ≤45% on echocardiography and no evidence of ischemia were enrolled. Clinical data, echocardiography, electrocardiography (ECG), coronary angiography and stress ECG information were collected from February 2020 to March 2022. Results: Of 402 patients, n = 220 (54.7%) were males with a median (IQR) age of 55.0 (41.0, 66.0) years. Causes of NIDCM were presumably hypertensive n = 218 (54.2%), idiopathic n = 116 (28.9%), PPCM n = 45 (11.2%), alcoholic n = 10 (2.5%) and other causes n = 13 (3.2%). The most common presenting symptoms were dyspnea n = 342 (85.1%), with the majority of patients presenting with New York Heart Association (NYHA) Class III n = 195 (48.5%). The mean (SD) left ventricular ejection fraction (LVEF) was 29.4% (±7.7), and severe systolic dysfunction (LVEF <30%) was common n = 208 (51.7%). Compared with other forms of DCM, idiopathic DCM patients were significantly younger, had more advanced NYHA class (p < 0.001) and presented more often with left bundle branch block on ECG (p = 0.0042). There was suboptimal use of novel guidelines recommended medications ARNI n = 10 (2.5%) and SGLT2 2-inhibitors n = 2 (0.5%). Conclusions: In our Tanzanian cohort, the majority of patients with NIDCM have an identified underlying cause, and they present at late stages of the disease. Patients with idiopathic DCM are younger with more severe disease compared to other forms of NIDCM. |
| first_indexed | 2024-04-24T23:45:53Z |
| format | Article |
| id | doaj.art-baab523e0c1644e499d6ee64eaf2254b |
| institution | Directory Open Access Journal |
| issn | 2211-8179 |
| language | English |
| last_indexed | 2024-04-24T23:45:53Z |
| publishDate | 2024-02-01 |
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| series | Global Heart |
| spelling | doaj.art-baab523e0c1644e499d6ee64eaf2254b2024-03-15T08:08:37ZengUbiquity PressGlobal Heart2211-81792024-02-01191262610.5334/gh.12981279Characterization of Non-Ischemic Dilated Cardiomyopathy in a Native Tanzanian Cohort: MOYO StudyLulu Said Fundikira0https://orcid.org/0000-0002-4953-7699Pilly Chillo1https://orcid.org/0000-0001-7073-1122Mohamed Z. Alimohamed2https://orcid.org/0000-0002-1240-928XHenry Mayala3https://orcid.org/0000-0001-9677-2520Engerasiya Kifai4https://orcid.org/0000-0001-6089-9087Geofrey M. Aloyce5https://orcid.org/0009-0005-0517-0222Appolinary Kamuhabwa6https://orcid.org/0000-0001-6895-9187Gideon Kwesigabo7https://orcid.org/0000-0003-3302-6736Linda W. van Laake8https://orcid.org/0000-0002-5027-0661Folkert W. Asselbergs9https://orcid.org/0000-0002-1692-8669Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of TanzaniaMuhimbili University of Health and Allied Sciences, Dar es Salaam; Jakaya Kikwete Cardiac Institute, Dar es SalaamMuhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania; Tanzania Human Genetics Organization, Dar es SalaamJakaya Kikwete Cardiac Institute, Dar es SalaamJakaya Kikwete Cardiac Institute, Dar es SalaamJakaya Kikwete Cardiac Institute, Dar es Salaam, Tanzania Appolinary Kamuhabwa, BPharm, PhDMuhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of TanzaniaMuhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of TanzaniaDepartment of Cardiology, Division of Heart and Lungs, University Medical Centre Utrecht, Utrecht University, UtrechtAmsterdam University Medical Centers, Department of Cardiology, University of Amsterdam, Amsterdam, NL; Health Data Research UK and Institute of Health Informatics, University College London, London; The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, LondonBackground: Non-ischemic dilated cardiomyopathy (NIDCM) is a common cause of heart failure with progressive tendency. The disease occurs in one in every 2,500 individuals in the developed world, with high morbidity and mortality. However, detailed data on the role of NIDCM in heart failure in Tanzania is lacking. Aim: To characterize NIDCM in a Tanzanian cohort with respect to demographics, clinical profile, imaging findings and management. Methods: Characterization of non-ischemic dilated cardioMyOpathY in a native Tanzanian cOhort (MOYO) is a prospective cohort study of NIDCM patients seen at the Jakaya Kikwete Cardiac Institute. Patients aged ≥18 years with a clinical diagnosis of heart failure, an ejection fraction of ≤45% on echocardiography and no evidence of ischemia were enrolled. Clinical data, echocardiography, electrocardiography (ECG), coronary angiography and stress ECG information were collected from February 2020 to March 2022. Results: Of 402 patients, n = 220 (54.7%) were males with a median (IQR) age of 55.0 (41.0, 66.0) years. Causes of NIDCM were presumably hypertensive n = 218 (54.2%), idiopathic n = 116 (28.9%), PPCM n = 45 (11.2%), alcoholic n = 10 (2.5%) and other causes n = 13 (3.2%). The most common presenting symptoms were dyspnea n = 342 (85.1%), with the majority of patients presenting with New York Heart Association (NYHA) Class III n = 195 (48.5%). The mean (SD) left ventricular ejection fraction (LVEF) was 29.4% (±7.7), and severe systolic dysfunction (LVEF <30%) was common n = 208 (51.7%). Compared with other forms of DCM, idiopathic DCM patients were significantly younger, had more advanced NYHA class (p < 0.001) and presented more often with left bundle branch block on ECG (p = 0.0042). There was suboptimal use of novel guidelines recommended medications ARNI n = 10 (2.5%) and SGLT2 2-inhibitors n = 2 (0.5%). Conclusions: In our Tanzanian cohort, the majority of patients with NIDCM have an identified underlying cause, and they present at late stages of the disease. Patients with idiopathic DCM are younger with more severe disease compared to other forms of NIDCM.https://account.globalheartjournal.com/index.php/up-j-gh/article/view/1298non-ischemic dilated cardiomyopathyheart failureechocardiography |
| spellingShingle | Lulu Said Fundikira Pilly Chillo Mohamed Z. Alimohamed Henry Mayala Engerasiya Kifai Geofrey M. Aloyce Appolinary Kamuhabwa Gideon Kwesigabo Linda W. van Laake Folkert W. Asselbergs Characterization of Non-Ischemic Dilated Cardiomyopathy in a Native Tanzanian Cohort: MOYO Study Global Heart non-ischemic dilated cardiomyopathy heart failure echocardiography |
| title | Characterization of Non-Ischemic Dilated Cardiomyopathy in a Native Tanzanian Cohort: MOYO Study |
| title_full | Characterization of Non-Ischemic Dilated Cardiomyopathy in a Native Tanzanian Cohort: MOYO Study |
| title_fullStr | Characterization of Non-Ischemic Dilated Cardiomyopathy in a Native Tanzanian Cohort: MOYO Study |
| title_full_unstemmed | Characterization of Non-Ischemic Dilated Cardiomyopathy in a Native Tanzanian Cohort: MOYO Study |
| title_short | Characterization of Non-Ischemic Dilated Cardiomyopathy in a Native Tanzanian Cohort: MOYO Study |
| title_sort | characterization of non ischemic dilated cardiomyopathy in a native tanzanian cohort moyo study |
| topic | non-ischemic dilated cardiomyopathy heart failure echocardiography |
| url | https://account.globalheartjournal.com/index.php/up-j-gh/article/view/1298 |
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