The garlic compound ajoene covalently binds vimentin, disrupts the vimentin network and exerts anti-metastatic activity in cancer cells

The garlic compound ajoene covalently binds vimentin, disrupts the vimentin network and exerts anti-metastatic activity in cancer cells

Abstract Background Garlic has been used for centuries for its flavour and health promoting properties that include protection against cancer. The vinyl disulfide-sulfoxide ajoene is one of the phytochemicals found in crushed cloves, hypothesised to act by S-thiolating reactive cysteines in target p...

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Bibliographic Details
Main Authors: Catherine H. Kaschula, Rosanna Tuveri, Ellen Ngarande, Kevin Dzobo, Christopher Barnett, Daniel A. Kusza, Lisa M. Graham, Arieh A. Katz, Mohamed Suhail Rafudeen, M. Iqbal Parker, Roger Hunter, Georgia Schäfer
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Cancer
Subjects:
Antimetastatic
Cancer
Garlic
Natural product
Ajoene
EMT
Online Access:http://link.springer.com/article/10.1186/s12885-019-5388-8

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