Th17/Treg Imbalance in Chronic Obstructive Pulmonary Disease: Clinical and Experimental Evidence
The imbalance between pro- and anti-inflammatory immune responses mediated by Th17 and Treg cells is deeply involved in the development and progression of inflammation in chronic obstructive pulmonary disease (COPD). Several clinical and experimental studies have described the Th17/Treg imbalance in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.804919/full |
| _version_ | 1830162665600712704 |
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| author | Juliana Dias Lourenço Juliana Tiyaki Ito Milton de Arruda Martins Iolanda de Fátima Lopes Calvo Tibério Fernanda Degobbi Tenorio Quirino dos Santos Lopes |
| author_facet | Juliana Dias Lourenço Juliana Tiyaki Ito Milton de Arruda Martins Iolanda de Fátima Lopes Calvo Tibério Fernanda Degobbi Tenorio Quirino dos Santos Lopes |
| author_sort | Juliana Dias Lourenço |
| collection | DOAJ |
| description | The imbalance between pro- and anti-inflammatory immune responses mediated by Th17 and Treg cells is deeply involved in the development and progression of inflammation in chronic obstructive pulmonary disease (COPD). Several clinical and experimental studies have described the Th17/Treg imbalance in COPD progression. Due to its importance, many studies have also evaluated the effect of different treatments targeting Th17/Treg cells. However, discrepant results have been observed among different lung compartments, different COPD stages or local and systemic markers. Thus, the data must be carefully examined. In this context, this review explores and summarizes the recent outcomes of Th17/Treg imbalance in COPD development and progression in clinical, experimental and in vitro studies. |
| first_indexed | 2024-12-17T15:23:08Z |
| format | Article |
| id | doaj.art-baae9f5bfeba4b3a8866c52baf74ea5c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-17T15:23:08Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-baae9f5bfeba4b3a8866c52baf74ea5c2022-12-21T21:43:20ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-12-011210.3389/fimmu.2021.804919804919Th17/Treg Imbalance in Chronic Obstructive Pulmonary Disease: Clinical and Experimental EvidenceJuliana Dias LourençoJuliana Tiyaki ItoMilton de Arruda MartinsIolanda de Fátima Lopes Calvo TibérioFernanda Degobbi Tenorio Quirino dos Santos LopesThe imbalance between pro- and anti-inflammatory immune responses mediated by Th17 and Treg cells is deeply involved in the development and progression of inflammation in chronic obstructive pulmonary disease (COPD). Several clinical and experimental studies have described the Th17/Treg imbalance in COPD progression. Due to its importance, many studies have also evaluated the effect of different treatments targeting Th17/Treg cells. However, discrepant results have been observed among different lung compartments, different COPD stages or local and systemic markers. Thus, the data must be carefully examined. In this context, this review explores and summarizes the recent outcomes of Th17/Treg imbalance in COPD development and progression in clinical, experimental and in vitro studies.https://www.frontiersin.org/articles/10.3389/fimmu.2021.804919/fullTh17 cells (Th17)regulatory T cell (Treg)Th17/Treg imbalanceCOPDimmune response |
| spellingShingle | Juliana Dias Lourenço Juliana Tiyaki Ito Milton de Arruda Martins Iolanda de Fátima Lopes Calvo Tibério Fernanda Degobbi Tenorio Quirino dos Santos Lopes Th17/Treg Imbalance in Chronic Obstructive Pulmonary Disease: Clinical and Experimental Evidence Frontiers in Immunology Th17 cells (Th17) regulatory T cell (Treg) Th17/Treg imbalance COPD immune response |
| title | Th17/Treg Imbalance in Chronic Obstructive Pulmonary Disease: Clinical and Experimental Evidence |
| title_full | Th17/Treg Imbalance in Chronic Obstructive Pulmonary Disease: Clinical and Experimental Evidence |
| title_fullStr | Th17/Treg Imbalance in Chronic Obstructive Pulmonary Disease: Clinical and Experimental Evidence |
| title_full_unstemmed | Th17/Treg Imbalance in Chronic Obstructive Pulmonary Disease: Clinical and Experimental Evidence |
| title_short | Th17/Treg Imbalance in Chronic Obstructive Pulmonary Disease: Clinical and Experimental Evidence |
| title_sort | th17 treg imbalance in chronic obstructive pulmonary disease clinical and experimental evidence |
| topic | Th17 cells (Th17) regulatory T cell (Treg) Th17/Treg imbalance COPD immune response |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.804919/full |
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