Anisotropic biomimetic trabecular porous three-dimensional-printed Ti-6Al-4V cage for lumbar interbody fusion
Lumbar fusion is a popular surgical procedure for the treatment of degenerative lumbar disc disease; however, it may be accompanied by complications, such as cage loosening, subsidence, and non-union. This study engineered and fabricated a three-dimensional (3D)-printed anisotropic biomimetic trabec...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S026412752300669X |
| _version_ | 1827804776964816896 |
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| author | Lincong Luo Jiaying Li Zhiwei Lin Xiulin Cheng Jiejie Wang Yilin Wang Yang Yang Shiyu Li Qinjie Ling Jianhui Dai Qinghong Wu Wenhua Huang |
| author_facet | Lincong Luo Jiaying Li Zhiwei Lin Xiulin Cheng Jiejie Wang Yilin Wang Yang Yang Shiyu Li Qinjie Ling Jianhui Dai Qinghong Wu Wenhua Huang |
| author_sort | Lincong Luo |
| collection | DOAJ |
| description | Lumbar fusion is a popular surgical procedure for the treatment of degenerative lumbar disc disease; however, it may be accompanied by complications, such as cage loosening, subsidence, and non-union. This study engineered and fabricated a three-dimensional (3D)-printed anisotropic biomimetic trabecular porous Ti-6Al-4V cage for lumbar interbody fusion. The study evaluated the structural design, manufacturability, mechanical properties, and cellular functions of the fabricated structures compared to currently available interbody cages. In vitro tests assessed the biofunctionality of the 3D-printed porous cage, which revealed anisotropic biomimetic trabecular porous Ti-6Al-4V cages with 65%-85% porosity, and 600 μm pore size. The microscopy analysis of surface properties indicated in situ micro- and nano-roughness. The mechanical properties decreased progressively with increasing porosity, and the optimized frame-reinforced porous cage achieved higher compressive strength and stiffness than the fully porous fusion. The 70% 3D-printed porous frame-reinforced cage had suitable mechanical performance compared with the polyether-ether-ketone (PEEK) cage. The anisotropic biomimetic trabecular porous structures and the surface micro- and nano-roughness modifications achieved excellent biological functions in vitro. In conclusion, our fabricated 70% 3D-printed porous frame-reinforced Ti-6Al-4V cage with anisotropic biomimetic trabeculae is a promising strategy for lumbar interbody fusion. |
| first_indexed | 2024-03-11T21:16:15Z |
| format | Article |
| id | doaj.art-baaf2a83c4664f0fbe24f080aaa7d106 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-03-11T21:16:15Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-baaf2a83c4664f0fbe24f080aaa7d1062023-09-29T04:43:33ZengElsevierMaterials & Design0264-12752023-09-01233112254Anisotropic biomimetic trabecular porous three-dimensional-printed Ti-6Al-4V cage for lumbar interbody fusionLincong Luo0Jiaying Li1Zhiwei Lin2Xiulin Cheng3Jiejie Wang4Yilin Wang5Yang Yang6Shiyu Li7Qinjie Ling8Jianhui Dai9Qinghong Wu10Wenhua Huang11The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province 350122, China; Guangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province 510515, ChinaGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province 510515, ChinaThe School of Basic Medical Sciences, Guangdong Medical University, Zhanjian, Guangdong Province 524001, ChinaThe School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province 350122, China; Guangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province 510515, ChinaGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province 510515, ChinaGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province 510515, ChinaGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province 510515, ChinaGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province 510515, ChinaDept of Spinal Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province 510120, ChinaSchool of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian Province 350122, China; School of Clinical Medicine, Putian University, Putian, Fujian Province 351100, ChinaLaboratory Animal Management Center, Southern Medical University, Guangzhou, Guangdong Province 510515,China; Corresponding authorsat: The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province 350122, China (W. Huang).The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province 350122, China; Guangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province 510515, China; The School of Basic Medical Sciences, Guangdong Medical University, Zhanjian, Guangdong Province 524001, China; Corresponding authorsat: The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province 350122, China (W. Huang).Lumbar fusion is a popular surgical procedure for the treatment of degenerative lumbar disc disease; however, it may be accompanied by complications, such as cage loosening, subsidence, and non-union. This study engineered and fabricated a three-dimensional (3D)-printed anisotropic biomimetic trabecular porous Ti-6Al-4V cage for lumbar interbody fusion. The study evaluated the structural design, manufacturability, mechanical properties, and cellular functions of the fabricated structures compared to currently available interbody cages. In vitro tests assessed the biofunctionality of the 3D-printed porous cage, which revealed anisotropic biomimetic trabecular porous Ti-6Al-4V cages with 65%-85% porosity, and 600 μm pore size. The microscopy analysis of surface properties indicated in situ micro- and nano-roughness. The mechanical properties decreased progressively with increasing porosity, and the optimized frame-reinforced porous cage achieved higher compressive strength and stiffness than the fully porous fusion. The 70% 3D-printed porous frame-reinforced cage had suitable mechanical performance compared with the polyether-ether-ketone (PEEK) cage. The anisotropic biomimetic trabecular porous structures and the surface micro- and nano-roughness modifications achieved excellent biological functions in vitro. In conclusion, our fabricated 70% 3D-printed porous frame-reinforced Ti-6Al-4V cage with anisotropic biomimetic trabeculae is a promising strategy for lumbar interbody fusion.http://www.sciencedirect.com/science/article/pii/S026412752300669XThree-dimensional printing technologyTi-6Al-4V interbody cageBiomimetic trabecular structure |
| spellingShingle | Lincong Luo Jiaying Li Zhiwei Lin Xiulin Cheng Jiejie Wang Yilin Wang Yang Yang Shiyu Li Qinjie Ling Jianhui Dai Qinghong Wu Wenhua Huang Anisotropic biomimetic trabecular porous three-dimensional-printed Ti-6Al-4V cage for lumbar interbody fusion Materials & Design Three-dimensional printing technology Ti-6Al-4V interbody cage Biomimetic trabecular structure |
| title | Anisotropic biomimetic trabecular porous three-dimensional-printed Ti-6Al-4V cage for lumbar interbody fusion |
| title_full | Anisotropic biomimetic trabecular porous three-dimensional-printed Ti-6Al-4V cage for lumbar interbody fusion |
| title_fullStr | Anisotropic biomimetic trabecular porous three-dimensional-printed Ti-6Al-4V cage for lumbar interbody fusion |
| title_full_unstemmed | Anisotropic biomimetic trabecular porous three-dimensional-printed Ti-6Al-4V cage for lumbar interbody fusion |
| title_short | Anisotropic biomimetic trabecular porous three-dimensional-printed Ti-6Al-4V cage for lumbar interbody fusion |
| title_sort | anisotropic biomimetic trabecular porous three dimensional printed ti 6al 4v cage for lumbar interbody fusion |
| topic | Three-dimensional printing technology Ti-6Al-4V interbody cage Biomimetic trabecular structure |
| url | http://www.sciencedirect.com/science/article/pii/S026412752300669X |
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