Noninvasive cardiac radioablation for ventricular tachycardia: dosimetric comparison between linear accelerator- and robotic CyberKnife-based radiosurgery systems
Abstract Background Few dosimetric comparisons have been published between linear accelerator (LA)-based systems and CyberKnife (CK)-based robotic radiosurgery systems for cardiac radio-ablation in ventricular tachycardia. This study aimed to compare the dosimetry of noninvasive cardiac radio-ablati...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-11-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13014-023-02370-w |
| _version_ | 1797630044968845312 |
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| author | Ching-Yu Wang Li-Ting Ho Lian-Yu Lin Hsing-Min Chan Hung-Yi Chen Tung-Lin Yu Yu-Sen Huang Sung-Hsin Kuo Wen-Jeng Lee Jenny Ling-Yu Chen |
| author_facet | Ching-Yu Wang Li-Ting Ho Lian-Yu Lin Hsing-Min Chan Hung-Yi Chen Tung-Lin Yu Yu-Sen Huang Sung-Hsin Kuo Wen-Jeng Lee Jenny Ling-Yu Chen |
| author_sort | Ching-Yu Wang |
| collection | DOAJ |
| description | Abstract Background Few dosimetric comparisons have been published between linear accelerator (LA)-based systems and CyberKnife (CK)-based robotic radiosurgery systems for cardiac radio-ablation in ventricular tachycardia. This study aimed to compare the dosimetry of noninvasive cardiac radio-ablation deliverable on LA with that on CK. Methods Thirteen patients who underwent noninvasive cardiac radio-ablation by LA were included. The prescribed dose was 25 Gy in 1 fraction, and the average planning target volume was 49.8 ± 31.0 cm3 (range, 14.4–93.7 cm3). CK plans were generated for comparison. Results Both the CK and LA plans accomplished appropriate dose coverage and normal tissue sparing. Compared with the LA plans, the CK plans achieved significantly lower gradient indices (3.12 ± 0.71 vs. 3.48 ± 0.55, p = 0.031) and gradient measures (1.00 ± 0.29 cm vs. 1.17 ± 0.29 cm, p < 0.001). They had similar equivalent conformity indices (CK vs. LA: 0.84 ± 0.08 vs. 0.87 ± 0.07, p = 0.093) and maximum doses 2 cm from the planning target volume (PTV) in any direction (CK vs. LA: 50.8 ± 9.9% vs. 53.1 ± 5.3%, p = 0.423). The dosimetric advantages of CK were more prominent in patients with a PTV of ≤ 50 cm3 or a spherical PTV. In patients with a PTV of > 50 cm3 or a non-spherical PTV, the LA and CK plans were similar regarding dosimetric parameters. CK plans involved more beams (232.2 ± 110.8 beams vs. 10.0 ± 1.7 arcs) and longer treatment times (119.2 ± 43.3 min vs. 22.4 ± 1.6 min, p = 0.007). Conclusions Both CK and LA are ideal modalities for noninvasive cardiac radio-ablation. Upfront treatment should be considered based on clinical intent. |
| first_indexed | 2024-03-11T11:02:30Z |
| format | Article |
| id | doaj.art-baafe4fc6e4746d58b62e962228df928 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-03-11T11:02:30Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-baafe4fc6e4746d58b62e962228df9282023-11-12T12:25:30ZengBMCRadiation Oncology1748-717X2023-11-0118111110.1186/s13014-023-02370-wNoninvasive cardiac radioablation for ventricular tachycardia: dosimetric comparison between linear accelerator- and robotic CyberKnife-based radiosurgery systemsChing-Yu Wang0Li-Ting Ho1Lian-Yu Lin2Hsing-Min Chan3Hung-Yi Chen4Tung-Lin Yu5Yu-Sen Huang6Sung-Hsin Kuo7Wen-Jeng Lee8Jenny Ling-Yu Chen9Division of Radiation Oncology, Department of Oncology, National Taiwan University HospitalDivision of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and HospitalDivision of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and HospitalDivision of Radiation Oncology, Department of Oncology, National Taiwan University HospitalDivision of Radiation Oncology, Department of Oncology, National Taiwan University HospitalDepartment of Radiation Oncology, Fu-Jen Catholic University HospitalDepartment of Medical Imaging, National Taiwan University HospitalDivision of Radiation Oncology, Department of Oncology, National Taiwan University HospitalDepartment of Medical Imaging, National Taiwan University HospitalDivision of Radiation Oncology, Department of Oncology, National Taiwan University HospitalAbstract Background Few dosimetric comparisons have been published between linear accelerator (LA)-based systems and CyberKnife (CK)-based robotic radiosurgery systems for cardiac radio-ablation in ventricular tachycardia. This study aimed to compare the dosimetry of noninvasive cardiac radio-ablation deliverable on LA with that on CK. Methods Thirteen patients who underwent noninvasive cardiac radio-ablation by LA were included. The prescribed dose was 25 Gy in 1 fraction, and the average planning target volume was 49.8 ± 31.0 cm3 (range, 14.4–93.7 cm3). CK plans were generated for comparison. Results Both the CK and LA plans accomplished appropriate dose coverage and normal tissue sparing. Compared with the LA plans, the CK plans achieved significantly lower gradient indices (3.12 ± 0.71 vs. 3.48 ± 0.55, p = 0.031) and gradient measures (1.00 ± 0.29 cm vs. 1.17 ± 0.29 cm, p < 0.001). They had similar equivalent conformity indices (CK vs. LA: 0.84 ± 0.08 vs. 0.87 ± 0.07, p = 0.093) and maximum doses 2 cm from the planning target volume (PTV) in any direction (CK vs. LA: 50.8 ± 9.9% vs. 53.1 ± 5.3%, p = 0.423). The dosimetric advantages of CK were more prominent in patients with a PTV of ≤ 50 cm3 or a spherical PTV. In patients with a PTV of > 50 cm3 or a non-spherical PTV, the LA and CK plans were similar regarding dosimetric parameters. CK plans involved more beams (232.2 ± 110.8 beams vs. 10.0 ± 1.7 arcs) and longer treatment times (119.2 ± 43.3 min vs. 22.4 ± 1.6 min, p = 0.007). Conclusions Both CK and LA are ideal modalities for noninvasive cardiac radio-ablation. Upfront treatment should be considered based on clinical intent.https://doi.org/10.1186/s13014-023-02370-wCyberKnifeLinear acceleratorCardiac radioablationVentricular tachycardia |
| spellingShingle | Ching-Yu Wang Li-Ting Ho Lian-Yu Lin Hsing-Min Chan Hung-Yi Chen Tung-Lin Yu Yu-Sen Huang Sung-Hsin Kuo Wen-Jeng Lee Jenny Ling-Yu Chen Noninvasive cardiac radioablation for ventricular tachycardia: dosimetric comparison between linear accelerator- and robotic CyberKnife-based radiosurgery systems Radiation Oncology CyberKnife Linear accelerator Cardiac radioablation Ventricular tachycardia |
| title | Noninvasive cardiac radioablation for ventricular tachycardia: dosimetric comparison between linear accelerator- and robotic CyberKnife-based radiosurgery systems |
| title_full | Noninvasive cardiac radioablation for ventricular tachycardia: dosimetric comparison between linear accelerator- and robotic CyberKnife-based radiosurgery systems |
| title_fullStr | Noninvasive cardiac radioablation for ventricular tachycardia: dosimetric comparison between linear accelerator- and robotic CyberKnife-based radiosurgery systems |
| title_full_unstemmed | Noninvasive cardiac radioablation for ventricular tachycardia: dosimetric comparison between linear accelerator- and robotic CyberKnife-based radiosurgery systems |
| title_short | Noninvasive cardiac radioablation for ventricular tachycardia: dosimetric comparison between linear accelerator- and robotic CyberKnife-based radiosurgery systems |
| title_sort | noninvasive cardiac radioablation for ventricular tachycardia dosimetric comparison between linear accelerator and robotic cyberknife based radiosurgery systems |
| topic | CyberKnife Linear accelerator Cardiac radioablation Ventricular tachycardia |
| url | https://doi.org/10.1186/s13014-023-02370-w |
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