Adenylate-cyclase activity in platelets of patients with obsessive-compulsive disorder
D Marazziti, S Baroni, L Palego, I Masala, G Consoli, M Catena Dell’Osso, G Giannaccini, A LucacchiniDipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Università di Pisa, Pisa, ItalyAbstract: Alt...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2009-07-01
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| Series: | Neuropsychiatric Disease and Treatment |
| Online Access: | http://www.dovepress.com/adenylate-cyclase-activity-in-platelets-of-patients-with-obsessive-com-a3318 |
| _version_ | 1818905835126915072 |
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| author | D Marazziti, S Baroni L Palego, I Masala, G Consoli M Catena Dell’Osso, G Giannaccini A Lucacchini |
| author_facet | D Marazziti, S Baroni L Palego, I Masala, G Consoli M Catena Dell’Osso, G Giannaccini A Lucacchini |
| author_sort | D Marazziti, S Baroni |
| collection | DOAJ |
| description | D Marazziti, S Baroni, L Palego, I Masala, G Consoli, M Catena Dell’Osso, G Giannaccini, A LucacchiniDipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Università di Pisa, Pisa, ItalyAbstract: Although the main biological hypothesis on the pathophysiology of obsessive-compulsive disorder (OCD) is centered on the serotonin system, indications are available that other neurotransmitters, and even second messengers, particularly the cyclic adenosine monophosphate (cAMP) signaling, may be involved, though effective data are few. Therefore, the aim of the present study was to evaluate and compare the basal and isoprenaline (ISO)-stimulated velocity of adenylate-cyclase (AC) in human platelet membranes of patients with OCD and healthy control subjects. The results showed that the basal and ISO-stimulated AC activity, as well as the dose-response curves of ISO by using agonist concentrations ranging between 0.1 nM and 10 µM, were not different in the two groups. However, OCD patients showed lower EC50 and higher Emax values than healthy subjects. These findings suggest the presence of supersensitive β-adrenergic receptors in platelets of OCD patients.Keywords: obsessive-compulsive disorder, norepinephrine, second messengers, adenylate-cyclase, platelets, isoprenaline, β-adrenergic receptors |
| first_indexed | 2024-12-19T21:29:38Z |
| format | Article |
| id | doaj.art-bab05ae95e244b45beae604d291c22e6 |
| institution | Directory Open Access Journal |
| issn | 1176-6328 1178-2021 |
| language | English |
| last_indexed | 2024-12-19T21:29:38Z |
| publishDate | 2009-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-bab05ae95e244b45beae604d291c22e62022-12-21T20:04:57ZengDove Medical PressNeuropsychiatric Disease and Treatment1176-63281178-20212009-07-012009default363367Adenylate-cyclase activity in platelets of patients with obsessive-compulsive disorderD Marazziti, S BaroniL Palego, I Masala, G ConsoliM Catena Dell’Osso, G GiannacciniA LucacchiniD Marazziti, S Baroni, L Palego, I Masala, G Consoli, M Catena Dell’Osso, G Giannaccini, A LucacchiniDipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Università di Pisa, Pisa, ItalyAbstract: Although the main biological hypothesis on the pathophysiology of obsessive-compulsive disorder (OCD) is centered on the serotonin system, indications are available that other neurotransmitters, and even second messengers, particularly the cyclic adenosine monophosphate (cAMP) signaling, may be involved, though effective data are few. Therefore, the aim of the present study was to evaluate and compare the basal and isoprenaline (ISO)-stimulated velocity of adenylate-cyclase (AC) in human platelet membranes of patients with OCD and healthy control subjects. The results showed that the basal and ISO-stimulated AC activity, as well as the dose-response curves of ISO by using agonist concentrations ranging between 0.1 nM and 10 µM, were not different in the two groups. However, OCD patients showed lower EC50 and higher Emax values than healthy subjects. These findings suggest the presence of supersensitive β-adrenergic receptors in platelets of OCD patients.Keywords: obsessive-compulsive disorder, norepinephrine, second messengers, adenylate-cyclase, platelets, isoprenaline, β-adrenergic receptorshttp://www.dovepress.com/adenylate-cyclase-activity-in-platelets-of-patients-with-obsessive-com-a3318 |
| spellingShingle | D Marazziti, S Baroni L Palego, I Masala, G Consoli M Catena Dell’Osso, G Giannaccini A Lucacchini Adenylate-cyclase activity in platelets of patients with obsessive-compulsive disorder Neuropsychiatric Disease and Treatment |
| title | Adenylate-cyclase activity in platelets of patients with obsessive-compulsive disorder |
| title_full | Adenylate-cyclase activity in platelets of patients with obsessive-compulsive disorder |
| title_fullStr | Adenylate-cyclase activity in platelets of patients with obsessive-compulsive disorder |
| title_full_unstemmed | Adenylate-cyclase activity in platelets of patients with obsessive-compulsive disorder |
| title_short | Adenylate-cyclase activity in platelets of patients with obsessive-compulsive disorder |
| title_sort | adenylate cyclase activity in platelets of patients with obsessive compulsive disorder |
| url | http://www.dovepress.com/adenylate-cyclase-activity-in-platelets-of-patients-with-obsessive-com-a3318 |
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