Immune modulatory effects of oncogenic KRAS in cancer
Oncogenic signalling has been historically associated with sustained cancer cell-intrinsic proliferation, however its role in promoting tumour immunoresistance has also become evident. Here, Hamarsheh and colleagues review and discuss the preclinical work on the immune modulatory effects of oncogeni...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19288-6 |
| _version_ | 1818433897062465536 |
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| author | Shaima’a Hamarsheh Olaf Groß Tilman Brummer Robert Zeiser |
| author_facet | Shaima’a Hamarsheh Olaf Groß Tilman Brummer Robert Zeiser |
| author_sort | Shaima’a Hamarsheh |
| collection | DOAJ |
| description | Oncogenic signalling has been historically associated with sustained cancer cell-intrinsic proliferation, however its role in promoting tumour immunoresistance has also become evident. Here, Hamarsheh and colleagues review and discuss the preclinical work on the immune modulatory effects of oncogenic KRAS and the potential clinical application. |
| first_indexed | 2024-12-14T16:28:23Z |
| format | Article |
| id | doaj.art-bab2055f90cc4a4aa21071e579d430b6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T16:28:23Z |
| publishDate | 2020-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-bab2055f90cc4a4aa21071e579d430b62022-12-21T22:54:39ZengNature PortfolioNature Communications2041-17232020-10-0111111110.1038/s41467-020-19288-6Immune modulatory effects of oncogenic KRAS in cancerShaima’a Hamarsheh0Olaf Groß1Tilman Brummer2Robert Zeiser3Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of FreiburgInstitute of Neuropathology, University Medical Center Freiburg, Faculty of Medicine, University of FreiburgInstitute of Molecular Medicine and Cell Research (IMMZ), Faculty of Medicine, University of FreiburgDepartment of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of FreiburgOncogenic signalling has been historically associated with sustained cancer cell-intrinsic proliferation, however its role in promoting tumour immunoresistance has also become evident. Here, Hamarsheh and colleagues review and discuss the preclinical work on the immune modulatory effects of oncogenic KRAS and the potential clinical application.https://doi.org/10.1038/s41467-020-19288-6 |
| spellingShingle | Shaima’a Hamarsheh Olaf Groß Tilman Brummer Robert Zeiser Immune modulatory effects of oncogenic KRAS in cancer Nature Communications |
| title | Immune modulatory effects of oncogenic KRAS in cancer |
| title_full | Immune modulatory effects of oncogenic KRAS in cancer |
| title_fullStr | Immune modulatory effects of oncogenic KRAS in cancer |
| title_full_unstemmed | Immune modulatory effects of oncogenic KRAS in cancer |
| title_short | Immune modulatory effects of oncogenic KRAS in cancer |
| title_sort | immune modulatory effects of oncogenic kras in cancer |
| url | https://doi.org/10.1038/s41467-020-19288-6 |
| work_keys_str_mv | AT shaimaahamarsheh immunemodulatoryeffectsofoncogenickrasincancer AT olafgroß immunemodulatoryeffectsofoncogenickrasincancer AT tilmanbrummer immunemodulatoryeffectsofoncogenickrasincancer AT robertzeiser immunemodulatoryeffectsofoncogenickrasincancer |