Molecular Analysis of the Superior Efficacy of a Dual Epidermal Growth Factor Receptor (EGFR)-DNA-Targeting Combi-Molecule in Comparison with Its Putative Prodrugs 6-Mono-Alkylamino- and 6,6-Dialkylaminoquinazoline in a Human Osteosarcoma Xenograft Model
<i>Background</i>: ZR2002 is a dual EGFR-DNA-targeting combi-molecule that carries a chloroethyl group at the six-position of the quinazoline ring designed to alkylate DNA. Despite its good pharmacokinetics, ZR2002 is metabolized in vivo into dechlorinated metabolites, losing the DNA-alk...
Main Authors: | Caterina Facchin, Ana B. Fraga-Timiraos, Julie Schmitt, Nadia Babaa, Naveet Pannu, Antonio Aliaga, Anne-Laure Larroque, Bertrand J. Jean-Claude |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-03-01
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Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/12/6/914 |
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