Approval rates for corneal donation and the origin of donor tissue for transplantation at a university-based tertiary referral center with corneal subspecialization hosting a LIONS Eye Bank
Abstract Background With the increasing demand for corneas, eye banks must optimize the tissue donation, collection, and selection process. This retrospective monocentric study analyzed the approval rates for corneal donation and the origin of and reasons for discarding donor corneas from 2010 to 20...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-01-01
|
| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-022-02248-7 |
| _version_ | 1818752857170509824 |
|---|---|
| author | Agata Anna Wykrota Isabel Weinstein Loïc Hamon Loay Daas Elias Flockerzi Shady Suffo Berthold Seitz |
| author_facet | Agata Anna Wykrota Isabel Weinstein Loïc Hamon Loay Daas Elias Flockerzi Shady Suffo Berthold Seitz |
| author_sort | Agata Anna Wykrota |
| collection | DOAJ |
| description | Abstract Background With the increasing demand for corneas, eye banks must optimize the tissue donation, collection, and selection process. This retrospective monocentric study analyzed the approval rates for corneal donation and the origin of and reasons for discarding donor corneas from 2010 to 2019. Methods Data included the number of deceased, approval or rejection by the family for corneal donation and contraindications. Corneal grafts were included from all deceased persons who were full-body and multi-organ donors at the Saarland University Medical Center (UKS) and from external institutions. Additional analyzed parameters included endothelial cell count (ECC), blood sample serology for infections, and conjunctival swab testing . Results A total of 1748 corneoscleral buttons were harvested from 10,265 deceased persons (17% with no contraindication) at the UKS between 2010 and 2019, with a consent rate of 23.3%. The number of keratoplasties increased from 136 in 2010 (15% of the deceased, total = 925) to 251 in 2019 (21%, total = 1214). Both the general and department-specific data showed similar percentages for corneal donation over the years, with intensive care and palliative units recently providing the most corneas. The increase in the number of corneas processed by the cornea bank over the years (368 in 2010 compared with 857 in 2019) was linked both to a better internal supply in 2010 (262, 71.2% of the total) compared with 2019 (519, 60.6%) and to an external supply by reinforcement of cooperation with external hospitals, including Luxembourg in 2010 (106, 28.8% of the total) compared with 2019 (338, 39.4%). A total of 195 of 377 corneas (52%) were discarded in 2009 compared with 260 out of 715 (36%) in 2019. The main reasons for discarding were low ECC (36% of discarded corneas in 2009; 11% in 2019), positive conjunctival swab (11% in 2009; 13% in 2019), and blood sample serology (6% in 2009 and in 2019). Conclusion Despite an increasing number of donors, the demand for corneas is still rising. Improved cooperation with internal departments and with external clinics has led to an increasing number of explanted corneas. The main reason for discarding corneas was low ECC, followed by a positive conjunctival swab for fungal or bacterial contamination and serology. Increased donation rates and continued improvements in collection and selection processes are necessary to cover the high demand for corneas. |
| first_indexed | 2024-12-18T04:58:07Z |
| format | Article |
| id | doaj.art-bab3ca9ade0242c682158f1067c1e1a3 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-18T04:58:07Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-bab3ca9ade0242c682158f1067c1e1a32022-12-21T21:20:14ZengBMCBMC Ophthalmology1471-24152022-01-0122111210.1186/s12886-022-02248-7Approval rates for corneal donation and the origin of donor tissue for transplantation at a university-based tertiary referral center with corneal subspecialization hosting a LIONS Eye BankAgata Anna Wykrota0Isabel Weinstein1Loïc Hamon2Loay Daas3Elias Flockerzi4Shady Suffo5Berthold Seitz6Department of Ophthalmology, Saarland University Medical Center (UKS)Department of Ophthalmology, Saarland University Medical Center (UKS)Department of Ophthalmology, Saarland University Medical Center (UKS)Department of Ophthalmology, Saarland University Medical Center (UKS)Department of Ophthalmology, Saarland University Medical Center (UKS)Department of Ophthalmology, Saarland University Medical Center (UKS)Department of Ophthalmology, Saarland University Medical Center (UKS)Abstract Background With the increasing demand for corneas, eye banks must optimize the tissue donation, collection, and selection process. This retrospective monocentric study analyzed the approval rates for corneal donation and the origin of and reasons for discarding donor corneas from 2010 to 2019. Methods Data included the number of deceased, approval or rejection by the family for corneal donation and contraindications. Corneal grafts were included from all deceased persons who were full-body and multi-organ donors at the Saarland University Medical Center (UKS) and from external institutions. Additional analyzed parameters included endothelial cell count (ECC), blood sample serology for infections, and conjunctival swab testing . Results A total of 1748 corneoscleral buttons were harvested from 10,265 deceased persons (17% with no contraindication) at the UKS between 2010 and 2019, with a consent rate of 23.3%. The number of keratoplasties increased from 136 in 2010 (15% of the deceased, total = 925) to 251 in 2019 (21%, total = 1214). Both the general and department-specific data showed similar percentages for corneal donation over the years, with intensive care and palliative units recently providing the most corneas. The increase in the number of corneas processed by the cornea bank over the years (368 in 2010 compared with 857 in 2019) was linked both to a better internal supply in 2010 (262, 71.2% of the total) compared with 2019 (519, 60.6%) and to an external supply by reinforcement of cooperation with external hospitals, including Luxembourg in 2010 (106, 28.8% of the total) compared with 2019 (338, 39.4%). A total of 195 of 377 corneas (52%) were discarded in 2009 compared with 260 out of 715 (36%) in 2019. The main reasons for discarding were low ECC (36% of discarded corneas in 2009; 11% in 2019), positive conjunctival swab (11% in 2009; 13% in 2019), and blood sample serology (6% in 2009 and in 2019). Conclusion Despite an increasing number of donors, the demand for corneas is still rising. Improved cooperation with internal departments and with external clinics has led to an increasing number of explanted corneas. The main reason for discarding corneas was low ECC, followed by a positive conjunctival swab for fungal or bacterial contamination and serology. Increased donation rates and continued improvements in collection and selection processes are necessary to cover the high demand for corneas.https://doi.org/10.1186/s12886-022-02248-7CorneaEye bankOrgan donationOrgan donor cardCorneal transplantationKeratoplasty |
| spellingShingle | Agata Anna Wykrota Isabel Weinstein Loïc Hamon Loay Daas Elias Flockerzi Shady Suffo Berthold Seitz Approval rates for corneal donation and the origin of donor tissue for transplantation at a university-based tertiary referral center with corneal subspecialization hosting a LIONS Eye Bank BMC Ophthalmology Cornea Eye bank Organ donation Organ donor card Corneal transplantation Keratoplasty |
| title | Approval rates for corneal donation and the origin of donor tissue for transplantation at a university-based tertiary referral center with corneal subspecialization hosting a LIONS Eye Bank |
| title_full | Approval rates for corneal donation and the origin of donor tissue for transplantation at a university-based tertiary referral center with corneal subspecialization hosting a LIONS Eye Bank |
| title_fullStr | Approval rates for corneal donation and the origin of donor tissue for transplantation at a university-based tertiary referral center with corneal subspecialization hosting a LIONS Eye Bank |
| title_full_unstemmed | Approval rates for corneal donation and the origin of donor tissue for transplantation at a university-based tertiary referral center with corneal subspecialization hosting a LIONS Eye Bank |
| title_short | Approval rates for corneal donation and the origin of donor tissue for transplantation at a university-based tertiary referral center with corneal subspecialization hosting a LIONS Eye Bank |
| title_sort | approval rates for corneal donation and the origin of donor tissue for transplantation at a university based tertiary referral center with corneal subspecialization hosting a lions eye bank |
| topic | Cornea Eye bank Organ donation Organ donor card Corneal transplantation Keratoplasty |
| url | https://doi.org/10.1186/s12886-022-02248-7 |
| work_keys_str_mv | AT agataannawykrota approvalratesforcornealdonationandtheoriginofdonortissuefortransplantationatauniversitybasedtertiaryreferralcenterwithcornealsubspecializationhostingalionseyebank AT isabelweinstein approvalratesforcornealdonationandtheoriginofdonortissuefortransplantationatauniversitybasedtertiaryreferralcenterwithcornealsubspecializationhostingalionseyebank AT loichamon approvalratesforcornealdonationandtheoriginofdonortissuefortransplantationatauniversitybasedtertiaryreferralcenterwithcornealsubspecializationhostingalionseyebank AT loaydaas approvalratesforcornealdonationandtheoriginofdonortissuefortransplantationatauniversitybasedtertiaryreferralcenterwithcornealsubspecializationhostingalionseyebank AT eliasflockerzi approvalratesforcornealdonationandtheoriginofdonortissuefortransplantationatauniversitybasedtertiaryreferralcenterwithcornealsubspecializationhostingalionseyebank AT shadysuffo approvalratesforcornealdonationandtheoriginofdonortissuefortransplantationatauniversitybasedtertiaryreferralcenterwithcornealsubspecializationhostingalionseyebank AT bertholdseitz approvalratesforcornealdonationandtheoriginofdonortissuefortransplantationatauniversitybasedtertiaryreferralcenterwithcornealsubspecializationhostingalionseyebank |