Histopathological Grading, Clinical Staging and CD 31 Expression of Canine Splenic Hemangiosarcoma
Canine hemangiosarcoma is a common, highly fatal tumor of older dogs, and predictors of survivability may provide clinically useful information. The objectives of this case series were to determine if a previously published tumor histological grading scheme, the level of tumor cellular atypia, clini...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/10/3/190 |
| _version_ | 1797608716440174592 |
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| author | Ka-To Chu Omid Nekouei Jeanine Rhoda Sandy |
| author_facet | Ka-To Chu Omid Nekouei Jeanine Rhoda Sandy |
| author_sort | Ka-To Chu |
| collection | DOAJ |
| description | Canine hemangiosarcoma is a common, highly fatal tumor of older dogs, and predictors of survivability may provide clinically useful information. The objectives of this case series were to determine if a previously published tumor histological grading scheme, the level of tumor cellular atypia, clinical staging, or the level of CD 31 expression were useful for predicting the survival time in dogs with splenic hemangiosarcoma. Canine splenic hemangiosarcomas from 16 dogs were histologically graded, clinically staged, and assessed for CD 31 expression. Medical records were reviewed, the date of death was obtained, and survival data were analyzed statistically. Histopathological grading and clinical staging of canine splenic hemangiosarcomas, and the expression of CD 31 by the tumor cells were not significantly associated with the median survival time of the dogs in this study. However, strong expression of CD 31 by canine splenic hemangiosarcoma tumor cells was observed in dogs with short survival times, which warrants further studies to evaluate the potential prognostic value of CD 31 expression for the survival of dogs with splenic hemangiosarcoma. |
| first_indexed | 2024-03-11T05:47:27Z |
| format | Article |
| id | doaj.art-bab46de0effa4a0a9347c84e5e0c4050 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-11T05:47:27Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-bab46de0effa4a0a9347c84e5e0c40502023-11-17T14:20:33ZengMDPI AGVeterinary Sciences2306-73812023-03-0110319010.3390/vetsci10030190Histopathological Grading, Clinical Staging and CD 31 Expression of Canine Splenic HemangiosarcomaKa-To Chu0Omid Nekouei1Jeanine Rhoda Sandy2Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong 999077, ChinaJockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong 999077, ChinaJockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong 999077, ChinaCanine hemangiosarcoma is a common, highly fatal tumor of older dogs, and predictors of survivability may provide clinically useful information. The objectives of this case series were to determine if a previously published tumor histological grading scheme, the level of tumor cellular atypia, clinical staging, or the level of CD 31 expression were useful for predicting the survival time in dogs with splenic hemangiosarcoma. Canine splenic hemangiosarcomas from 16 dogs were histologically graded, clinically staged, and assessed for CD 31 expression. Medical records were reviewed, the date of death was obtained, and survival data were analyzed statistically. Histopathological grading and clinical staging of canine splenic hemangiosarcomas, and the expression of CD 31 by the tumor cells were not significantly associated with the median survival time of the dogs in this study. However, strong expression of CD 31 by canine splenic hemangiosarcoma tumor cells was observed in dogs with short survival times, which warrants further studies to evaluate the potential prognostic value of CD 31 expression for the survival of dogs with splenic hemangiosarcoma.https://www.mdpi.com/2306-7381/10/3/190canine splenic hemangiosarcomaprognosisgradingCD 31 |
| spellingShingle | Ka-To Chu Omid Nekouei Jeanine Rhoda Sandy Histopathological Grading, Clinical Staging and CD 31 Expression of Canine Splenic Hemangiosarcoma Veterinary Sciences canine splenic hemangiosarcoma prognosis grading CD 31 |
| title | Histopathological Grading, Clinical Staging and CD 31 Expression of Canine Splenic Hemangiosarcoma |
| title_full | Histopathological Grading, Clinical Staging and CD 31 Expression of Canine Splenic Hemangiosarcoma |
| title_fullStr | Histopathological Grading, Clinical Staging and CD 31 Expression of Canine Splenic Hemangiosarcoma |
| title_full_unstemmed | Histopathological Grading, Clinical Staging and CD 31 Expression of Canine Splenic Hemangiosarcoma |
| title_short | Histopathological Grading, Clinical Staging and CD 31 Expression of Canine Splenic Hemangiosarcoma |
| title_sort | histopathological grading clinical staging and cd 31 expression of canine splenic hemangiosarcoma |
| topic | canine splenic hemangiosarcoma prognosis grading CD 31 |
| url | https://www.mdpi.com/2306-7381/10/3/190 |
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