The link between the sphingolipid rheostat and obstructive sleep apnea
Abstract Chronic inflammation induced by hypoxia during sleep is an important mechanism of microvascular damage in OSA patients. In this study, we investigated the role of the sphingosine rheostat, which has diverse inflammatory effects. Thirty-seven healthy subjects and 31 patients with OSA were re...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-34717-4 |
| _version_ | 1797827596326535168 |
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| author | Péter Horváth Lilla Büdi Dániel Hammer Rita Varga György Losonczy Ádám Domonkos Tárnoki Dávid László Tárnoki Martina Mészáros András Bikov |
| author_facet | Péter Horváth Lilla Büdi Dániel Hammer Rita Varga György Losonczy Ádám Domonkos Tárnoki Dávid László Tárnoki Martina Mészáros András Bikov |
| author_sort | Péter Horváth |
| collection | DOAJ |
| description | Abstract Chronic inflammation induced by hypoxia during sleep is an important mechanism of microvascular damage in OSA patients. In this study, we investigated the role of the sphingosine rheostat, which has diverse inflammatory effects. Thirty-seven healthy subjects and 31 patients with OSA were recruited. We collected data on demographics and comorbidities. Plasma sphingosine-1-phosphate and ceramide antibody concentrations were measured by ELISA. The results were compared between the OSA and control groups, and the correlations between these measurements and markers of disease severity and comorbidities were explored. Ceramide antibody levels were significantly elevated in OSA patients (892.17 ng/ml) vs. controls (209.55 ng/ml). S1P levels were also significantly higher in patients with OSA (1760.0 pg/ml) than in controls (290.35 pg/ml, p < 0.001). The ceramide antibody concentration showed correlations with BMI (ρ = 0.25, p = 0.04), CRP (ρ = 0.36, p = 0.005), AHI (ρ = 0.43, p < 0.001), ODI (ρ = 0.43, p < 0.001), TST90% (ρ = 0.35, p = 0.004) and the lowest oxygen saturation (ρ = 0.37, p = 0.001) in the whole study population but not when patients with OSA were analyzed separately. The elevated ceramide antibody and sphingosine-1-phosphate concentrations in patients suffering from OSA suggests their involvement in the pathomechanism of OSA and its comorbidities. |
| first_indexed | 2024-04-09T12:50:51Z |
| format | Article |
| id | doaj.art-bab4b6bb5b2647e5a4b588bb589a79ee |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T12:50:51Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-bab4b6bb5b2647e5a4b588bb589a79ee2023-05-14T11:13:05ZengNature PortfolioScientific Reports2045-23222023-05-011311810.1038/s41598-023-34717-4The link between the sphingolipid rheostat and obstructive sleep apneaPéter Horváth0Lilla Büdi1Dániel Hammer2Rita Varga3György Losonczy4Ádám Domonkos Tárnoki5Dávid László Tárnoki6Martina Mészáros7András Bikov8Department of Pulmonology, Semmelweis UniversityDepartment of Pulmonology, Semmelweis UniversityDepartment of Pulmonology, Semmelweis UniversityDepartment of Pulmonology, Semmelweis UniversityDepartment of Pulmonology, Semmelweis UniversityMedical Imaging Centre, Semmelweis UniversityMedical Imaging Centre, Semmelweis UniversityUniversity Hospital ZürichManchester University NHS Foundation TrustAbstract Chronic inflammation induced by hypoxia during sleep is an important mechanism of microvascular damage in OSA patients. In this study, we investigated the role of the sphingosine rheostat, which has diverse inflammatory effects. Thirty-seven healthy subjects and 31 patients with OSA were recruited. We collected data on demographics and comorbidities. Plasma sphingosine-1-phosphate and ceramide antibody concentrations were measured by ELISA. The results were compared between the OSA and control groups, and the correlations between these measurements and markers of disease severity and comorbidities were explored. Ceramide antibody levels were significantly elevated in OSA patients (892.17 ng/ml) vs. controls (209.55 ng/ml). S1P levels were also significantly higher in patients with OSA (1760.0 pg/ml) than in controls (290.35 pg/ml, p < 0.001). The ceramide antibody concentration showed correlations with BMI (ρ = 0.25, p = 0.04), CRP (ρ = 0.36, p = 0.005), AHI (ρ = 0.43, p < 0.001), ODI (ρ = 0.43, p < 0.001), TST90% (ρ = 0.35, p = 0.004) and the lowest oxygen saturation (ρ = 0.37, p = 0.001) in the whole study population but not when patients with OSA were analyzed separately. The elevated ceramide antibody and sphingosine-1-phosphate concentrations in patients suffering from OSA suggests their involvement in the pathomechanism of OSA and its comorbidities.https://doi.org/10.1038/s41598-023-34717-4 |
| spellingShingle | Péter Horváth Lilla Büdi Dániel Hammer Rita Varga György Losonczy Ádám Domonkos Tárnoki Dávid László Tárnoki Martina Mészáros András Bikov The link between the sphingolipid rheostat and obstructive sleep apnea Scientific Reports |
| title | The link between the sphingolipid rheostat and obstructive sleep apnea |
| title_full | The link between the sphingolipid rheostat and obstructive sleep apnea |
| title_fullStr | The link between the sphingolipid rheostat and obstructive sleep apnea |
| title_full_unstemmed | The link between the sphingolipid rheostat and obstructive sleep apnea |
| title_short | The link between the sphingolipid rheostat and obstructive sleep apnea |
| title_sort | link between the sphingolipid rheostat and obstructive sleep apnea |
| url | https://doi.org/10.1038/s41598-023-34717-4 |
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