Comparison of effects of ketamine, ketamine-dexmedetomidine and ketamine-midazolam on dressing changes of burn patients
Objective: The aim of this randomized, controlled study was to compare the sedoanalgesic effects of ketamine-dexmedetomidine and ketamine-midazolam on dressing changes of burn patients. Materials and Methods: Following Ethics Committee approval and informed patient consent, 90 ASA physical statuse...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Journal of Anaesthesiology Clinical Pharmacology |
| Subjects: | |
| Online Access: | http://www.joacp.org/article.asp?issn=0970-9185;year=2011;volume=27;issue=2;spage=220;epage=224;aulast=Gündüz |
| _version_ | 1818556254940823552 |
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| author | Murat Gündüz Sefika Sakalli Yasemin Günes Erol Kesiktas Dilek Özcengiz Geylan Isik |
| author_facet | Murat Gündüz Sefika Sakalli Yasemin Günes Erol Kesiktas Dilek Özcengiz Geylan Isik |
| author_sort | Murat Gündüz |
| collection | DOAJ |
| description | Objective: The aim of this randomized, controlled study was to compare the sedoanalgesic effects of ketamine-dexmedetomidine and ketamine-midazolam on dressing changes of burn patients.
Materials and Methods: Following Ethics Committee approval and informed patient consent, 90 ASA physical statuses I and II adult burn patients were included in the study. Patients were randomly divided into three groups. Ten minutes before dressing change, the dexmedetomidine group (group KD) ( n=30) received a continuous infusion of dexmedetomidine at a rate of 1 μg kg-1 , the midazolam group (group KM) ( n=30) received a continuous infusion of midazolam at a rate of 0.05 mg kg-1 and the saline group (group KS) ( n=30) received a continuous infusion of saline intravenously. One minute before dressing change, each patient was administered 1 mg kg-1 ketamine intravenously. Hemodynamic variables, pain and sedation scores, the number of patients requiring additional ketamine, time to dressing change and recovery time were recorded.
Results: Systolic blood pressure (SBP) values were significantly lower at, before and after ketamine administration; and
5, 10 and 15 minutes after the procedure in group KD in comparison with the other groups ( P<0.05). There was no significant difference in pain scores among the groups during the study period. Sedation scores were significantly higher in group KD than in groups KM and KS at the end of the first hour ( P<0.05). Time to dressing change and recovery time were similar in all the groups.
Conclusion: In burn patients undergoing dressing changes, although both combinations ketamine-dexmedetomidine and ketamine-midazolam offered an effective sedoanalgesia without causing any significant side effect, the former resulted in higher sedation and lower hemodynamic discrepancy. |
| first_indexed | 2024-12-13T23:44:58Z |
| format | Article |
| id | doaj.art-bab4e725cbd54ad8b5919e5719db1a09 |
| institution | Directory Open Access Journal |
| issn | 0970-9185 |
| language | English |
| last_indexed | 2024-12-13T23:44:58Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Anaesthesiology Clinical Pharmacology |
| spelling | doaj.art-bab4e725cbd54ad8b5919e5719db1a092022-12-21T23:27:02ZengWolters Kluwer Medknow PublicationsJournal of Anaesthesiology Clinical Pharmacology0970-91852011-01-0127222022410.4103/0970-9185.81823Comparison of effects of ketamine, ketamine-dexmedetomidine and ketamine-midazolam on dressing changes of burn patientsMurat GündüzSefika SakalliYasemin GünesErol KesiktasDilek ÖzcengizGeylan IsikObjective: The aim of this randomized, controlled study was to compare the sedoanalgesic effects of ketamine-dexmedetomidine and ketamine-midazolam on dressing changes of burn patients. Materials and Methods: Following Ethics Committee approval and informed patient consent, 90 ASA physical statuses I and II adult burn patients were included in the study. Patients were randomly divided into three groups. Ten minutes before dressing change, the dexmedetomidine group (group KD) ( n=30) received a continuous infusion of dexmedetomidine at a rate of 1 μg kg-1 , the midazolam group (group KM) ( n=30) received a continuous infusion of midazolam at a rate of 0.05 mg kg-1 and the saline group (group KS) ( n=30) received a continuous infusion of saline intravenously. One minute before dressing change, each patient was administered 1 mg kg-1 ketamine intravenously. Hemodynamic variables, pain and sedation scores, the number of patients requiring additional ketamine, time to dressing change and recovery time were recorded. Results: Systolic blood pressure (SBP) values were significantly lower at, before and after ketamine administration; and 5, 10 and 15 minutes after the procedure in group KD in comparison with the other groups ( P<0.05). There was no significant difference in pain scores among the groups during the study period. Sedation scores were significantly higher in group KD than in groups KM and KS at the end of the first hour ( P<0.05). Time to dressing change and recovery time were similar in all the groups. Conclusion: In burn patients undergoing dressing changes, although both combinations ketamine-dexmedetomidine and ketamine-midazolam offered an effective sedoanalgesia without causing any significant side effect, the former resulted in higher sedation and lower hemodynamic discrepancy.http://www.joacp.org/article.asp?issn=0970-9185;year=2011;volume=27;issue=2;spage=220;epage=224;aulast=GündüzBurndexmedetomidinedressing changesketaminemidazolam |
| spellingShingle | Murat Gündüz Sefika Sakalli Yasemin Günes Erol Kesiktas Dilek Özcengiz Geylan Isik Comparison of effects of ketamine, ketamine-dexmedetomidine and ketamine-midazolam on dressing changes of burn patients Journal of Anaesthesiology Clinical Pharmacology Burn dexmedetomidine dressing changes ketamine midazolam |
| title | Comparison of effects of ketamine, ketamine-dexmedetomidine and ketamine-midazolam on dressing changes of burn patients |
| title_full | Comparison of effects of ketamine, ketamine-dexmedetomidine and ketamine-midazolam on dressing changes of burn patients |
| title_fullStr | Comparison of effects of ketamine, ketamine-dexmedetomidine and ketamine-midazolam on dressing changes of burn patients |
| title_full_unstemmed | Comparison of effects of ketamine, ketamine-dexmedetomidine and ketamine-midazolam on dressing changes of burn patients |
| title_short | Comparison of effects of ketamine, ketamine-dexmedetomidine and ketamine-midazolam on dressing changes of burn patients |
| title_sort | comparison of effects of ketamine ketamine dexmedetomidine and ketamine midazolam on dressing changes of burn patients |
| topic | Burn dexmedetomidine dressing changes ketamine midazolam |
| url | http://www.joacp.org/article.asp?issn=0970-9185;year=2011;volume=27;issue=2;spage=220;epage=224;aulast=Gündüz |
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