Clinical and epidemiological features of patients with COVID-19 reinfection: a systematic review
Recurrent positivity in a patient with COVID-19 may be due to various reasons, not necessarily reinfection. There is concern about the occurrence frequency of reinfection. Five databases and a preprint/preprint repository were searched. All case reports, case series, and observational studies were i...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | New Microbes and New Infections |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2052297522000737 |
| _version_ | 1797988974300495872 |
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| author | C.J. Toro-Huamanchumo M.M. Hilario-Gomez L. Pinedo-Castillo C.J. Zumarán-Nuñez F. Espinoza-Gonzales J. Caballero-Alvarado A.J. Rodriguez-Morales J.J. Barboza |
| author_facet | C.J. Toro-Huamanchumo M.M. Hilario-Gomez L. Pinedo-Castillo C.J. Zumarán-Nuñez F. Espinoza-Gonzales J. Caballero-Alvarado A.J. Rodriguez-Morales J.J. Barboza |
| author_sort | C.J. Toro-Huamanchumo |
| collection | DOAJ |
| description | Recurrent positivity in a patient with COVID-19 may be due to various reasons, not necessarily reinfection. There is concern about the occurrence frequency of reinfection. Five databases and a preprint/preprint repository were searched. All case reports, case series, and observational studies were included. Bias was assessed for each study with the Newcastle-Ottawa Scale tool and reported according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA-2020). After eligibility, 77 studies were included for qualitative synthesis (52 case reports, 21 case series, and four case-controls; 1131 patients included). Of these, 16 studies described a second contact with the SARS-CoV-2 positive case, five studies described healthcare profession-related infection, ten studies described that the source of reinfection was likely to be from the community, one study described travel-related infection, nine studies described vulnerability-related infection due to comorbidity. The mean number of days from discharge or negative test to reinfection ranged from 23.3 to 57.6 days across the different included studies. The risk of bias for all case report/series studies was moderate/high. For observational studies, the risk of bias was low. Reinfection of patients with COVID-19 occurs between the first and second month after the first infection, but beyond, and 90 days have been proposed as a point to begin to consider it. The main factor for reinfection is contact with COVID-19 positive cases. |
| first_indexed | 2024-04-11T08:12:55Z |
| format | Article |
| id | doaj.art-bab61b3d896440b3bb27605b0ae55467 |
| institution | Directory Open Access Journal |
| issn | 2052-2975 |
| language | English |
| last_indexed | 2024-04-11T08:12:55Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | New Microbes and New Infections |
| spelling | doaj.art-bab61b3d896440b3bb27605b0ae554672022-12-22T04:35:18ZengElsevierNew Microbes and New Infections2052-29752022-07-0148101021Clinical and epidemiological features of patients with COVID-19 reinfection: a systematic reviewC.J. Toro-Huamanchumo0M.M. Hilario-Gomez1L. Pinedo-Castillo2C.J. Zumarán-Nuñez3F. Espinoza-Gonzales4J. Caballero-Alvarado5A.J. Rodriguez-Morales6J.J. Barboza7Universidad César Vallejo, Trujillo, PeruSociedad científica de San Fernando, Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Señor de Sipán, Chiclayo, PeruAsociación Científica de Estudiantes de Medicina de la Universidad Señor de Sipán, Escuela Profesional de Medicina Humana de la Universidad Señor de Sipán, Chiclayo, Peru; Universidad Señor de Sipán, Chiclayo, PeruAsociación Científica de Estudiantes de Medicina de la Universidad Señor de Sipán, Escuela Profesional de Medicina Humana de la Universidad Señor de Sipán, Chiclayo, Peru; Universidad Señor de Sipán, Chiclayo, PeruAsociación Científica de Estudiantes de Medicina de la Universidad Señor de Sipán, Escuela Profesional de Medicina Humana de la Universidad Señor de Sipán, Chiclayo, Peru; Universidad Señor de Sipán, Chiclayo, PeruEscuela de Medicina, Universidad Privada Antenor Orrego, Peru; Universidad Señor de Sipán, Chiclayo, PeruGrupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia; Universidad Cientifica del Sur, Lima, PeruUniversidad Señor de Sipán, Chiclayo, Peru; Corresponding author: Juan del Corral, 937. El Bosque, Trujillo, Peru.Recurrent positivity in a patient with COVID-19 may be due to various reasons, not necessarily reinfection. There is concern about the occurrence frequency of reinfection. Five databases and a preprint/preprint repository were searched. All case reports, case series, and observational studies were included. Bias was assessed for each study with the Newcastle-Ottawa Scale tool and reported according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA-2020). After eligibility, 77 studies were included for qualitative synthesis (52 case reports, 21 case series, and four case-controls; 1131 patients included). Of these, 16 studies described a second contact with the SARS-CoV-2 positive case, five studies described healthcare profession-related infection, ten studies described that the source of reinfection was likely to be from the community, one study described travel-related infection, nine studies described vulnerability-related infection due to comorbidity. The mean number of days from discharge or negative test to reinfection ranged from 23.3 to 57.6 days across the different included studies. The risk of bias for all case report/series studies was moderate/high. For observational studies, the risk of bias was low. Reinfection of patients with COVID-19 occurs between the first and second month after the first infection, but beyond, and 90 days have been proposed as a point to begin to consider it. The main factor for reinfection is contact with COVID-19 positive cases.http://www.sciencedirect.com/science/article/pii/S2052297522000737COVID-19pandemicrecurrencereinfectionSARS-CoV-2 |
| spellingShingle | C.J. Toro-Huamanchumo M.M. Hilario-Gomez L. Pinedo-Castillo C.J. Zumarán-Nuñez F. Espinoza-Gonzales J. Caballero-Alvarado A.J. Rodriguez-Morales J.J. Barboza Clinical and epidemiological features of patients with COVID-19 reinfection: a systematic review New Microbes and New Infections COVID-19 pandemic recurrence reinfection SARS-CoV-2 |
| title | Clinical and epidemiological features of patients with COVID-19 reinfection: a systematic review |
| title_full | Clinical and epidemiological features of patients with COVID-19 reinfection: a systematic review |
| title_fullStr | Clinical and epidemiological features of patients with COVID-19 reinfection: a systematic review |
| title_full_unstemmed | Clinical and epidemiological features of patients with COVID-19 reinfection: a systematic review |
| title_short | Clinical and epidemiological features of patients with COVID-19 reinfection: a systematic review |
| title_sort | clinical and epidemiological features of patients with covid 19 reinfection a systematic review |
| topic | COVID-19 pandemic recurrence reinfection SARS-CoV-2 |
| url | http://www.sciencedirect.com/science/article/pii/S2052297522000737 |
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