Effect of extracorporeal hemoadsorption in critically ill patients with COVID-19: A narrative review
COVID-19 has been affecting the world unprecedentedly and will remain widely prevalent due to its elusive pathophysiological mechanism and the continuous emergence of new variants. Critically ill patients with COVID-19 are commonly associated with cytokine storm, multiple organ dysfunction, and high...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1074465/full |
| _version_ | 1811173231633104896 |
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| author | Kaixi Chang Yupei Li Zheng Qin Zhuyun Zhang Liya Wang Qinbo Yang Jiwen Geng Ningyue Deng Shanshan Chen Baihai Su Baihai Su Baihai Su |
| author_facet | Kaixi Chang Yupei Li Zheng Qin Zhuyun Zhang Liya Wang Qinbo Yang Jiwen Geng Ningyue Deng Shanshan Chen Baihai Su Baihai Su Baihai Su |
| author_sort | Kaixi Chang |
| collection | DOAJ |
| description | COVID-19 has been affecting the world unprecedentedly and will remain widely prevalent due to its elusive pathophysiological mechanism and the continuous emergence of new variants. Critically ill patients with COVID-19 are commonly associated with cytokine storm, multiple organ dysfunction, and high mortality. To date, growing evidence has shown that extracorporeal hemoadsorption can exert its adjuvant effect to standard of care by regulating immune homeostasis, reducing viremia, and decreasing endotoxin activity in critically ill COVID-19 cases. However, the selection of various hemofilters, timing of initiation and termination of hemoadsorption therapy, anticoagulation management of extracorporeal circuits, identification of target subgroups, and ultimate survival benefit remain controversial. The purpose of this narrative review is to comprehensively summarize the rationale for the use of hemoadsorption in critically ill patients with COVID-19 and to gather the latest clinical evidence in this field. |
| first_indexed | 2024-04-10T17:44:38Z |
| format | Article |
| id | doaj.art-bab7f2a44fa8426aa379d328113f4344 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T17:44:38Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-bab7f2a44fa8426aa379d328113f43442023-02-03T06:07:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011410.3389/fimmu.2023.10744651074465Effect of extracorporeal hemoadsorption in critically ill patients with COVID-19: A narrative reviewKaixi Chang0Yupei Li1Zheng Qin2Zhuyun Zhang3Liya Wang4Qinbo Yang5Jiwen Geng6Ningyue Deng7Shanshan Chen8Baihai Su9Baihai Su10Baihai Su11Department of Nephrology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, ChinaMed-X Center for Materials, Sichuan University, Chengdu, ChinaMed+ Biomaterial Institute of West China Hospital, Sichuan University, Chengdu, ChinaCOVID-19 has been affecting the world unprecedentedly and will remain widely prevalent due to its elusive pathophysiological mechanism and the continuous emergence of new variants. Critically ill patients with COVID-19 are commonly associated with cytokine storm, multiple organ dysfunction, and high mortality. To date, growing evidence has shown that extracorporeal hemoadsorption can exert its adjuvant effect to standard of care by regulating immune homeostasis, reducing viremia, and decreasing endotoxin activity in critically ill COVID-19 cases. However, the selection of various hemofilters, timing of initiation and termination of hemoadsorption therapy, anticoagulation management of extracorporeal circuits, identification of target subgroups, and ultimate survival benefit remain controversial. The purpose of this narrative review is to comprehensively summarize the rationale for the use of hemoadsorption in critically ill patients with COVID-19 and to gather the latest clinical evidence in this field.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1074465/fullCOVID-19hemoadsorptioncytokine storminflammatory mediatorsimmunomodulatoryblood purification |
| spellingShingle | Kaixi Chang Yupei Li Zheng Qin Zhuyun Zhang Liya Wang Qinbo Yang Jiwen Geng Ningyue Deng Shanshan Chen Baihai Su Baihai Su Baihai Su Effect of extracorporeal hemoadsorption in critically ill patients with COVID-19: A narrative review Frontiers in Immunology COVID-19 hemoadsorption cytokine storm inflammatory mediators immunomodulatory blood purification |
| title | Effect of extracorporeal hemoadsorption in critically ill patients with COVID-19: A narrative review |
| title_full | Effect of extracorporeal hemoadsorption in critically ill patients with COVID-19: A narrative review |
| title_fullStr | Effect of extracorporeal hemoadsorption in critically ill patients with COVID-19: A narrative review |
| title_full_unstemmed | Effect of extracorporeal hemoadsorption in critically ill patients with COVID-19: A narrative review |
| title_short | Effect of extracorporeal hemoadsorption in critically ill patients with COVID-19: A narrative review |
| title_sort | effect of extracorporeal hemoadsorption in critically ill patients with covid 19 a narrative review |
| topic | COVID-19 hemoadsorption cytokine storm inflammatory mediators immunomodulatory blood purification |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1074465/full |
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