(E)-2-Cyano-3-(1<i>H</i>-Indol-3-yl)-N-Phenylacrylamide, a Hybrid Compound Derived from Indomethacin and Paracetamol: Design, Synthesis and Evaluation of the Anti-Inflammatory Potential

(E)-2-Cyano-3-(1<i>H</i>-Indol-3-yl)-N-Phenylacrylamide, a Hybrid Compound Derived from Indomethacin and Paracetamol: Design, Synthesis and Evaluation of the Anti-Inflammatory Potential

The compound (E)-2-cyano-3-(1H-indol-3-yl)-N-phenylacrylamide (ICMD-01) was designed and developed based on the structures of clinically relevant drugs indomethacin and paracetamol through the molecular hybridization strategy. This derivative was obtained by an amidation reaction between substituted...

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Bibliographic Details
Main Authors: Pablo Silva, Maria de Almeida, Jamire Silva, Sonaly Albino, Renan Espírito-Santo, Maria Lima, Cristiane Villarreal, Ricardo Moura, Vanda Santos
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
cytokines
paw edema
PGE<sub>2</sub>
phenylacrylamide
Online Access:https://www.mdpi.com/1422-0067/21/7/2591

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