Interdisciplinary Collaboration on Real World Data to Close the Knowledge Gap: A Reflection on “De Sutter et al. Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling”
This commentary further reflects on the paper of De Sutter et al. on predicting volume of distribution in neonates, and the performance of physiologically based pharmacokinetic models We hereby stressed the add on value to collaborate on real world data to further close this knowledge gap. We illust...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-01-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/16/1/128 |
| _version_ | 1797342748970319872 |
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| author | Karel Allegaert Anne Smits Pieter Annaert |
| author_facet | Karel Allegaert Anne Smits Pieter Annaert |
| author_sort | Karel Allegaert |
| collection | DOAJ |
| description | This commentary further reflects on the paper of De Sutter et al. on predicting volume of distribution in neonates, and the performance of physiologically based pharmacokinetic models We hereby stressed the add on value to collaborate on real world data to further close this knowledge gap. We illustrated this by weight distribution characteristics in breastfed (physiology) and in asphyxiated (pathophysiology), with additional reflection on their kidney and liver function. |
| first_indexed | 2024-03-08T10:37:47Z |
| format | Article |
| id | doaj.art-babb958d9cdd43d3a728bd820082bef0 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-08T10:37:47Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-babb958d9cdd43d3a728bd820082bef02024-01-26T18:08:07ZengMDPI AGPharmaceutics1999-49232024-01-0116112810.3390/pharmaceutics16010128Interdisciplinary Collaboration on Real World Data to Close the Knowledge Gap: A Reflection on “De Sutter et al. Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling”Karel Allegaert0Anne Smits1Pieter Annaert2Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, BelgiumDepartment of Development and Regeneration, KU Leuven, 3000 Leuven, BelgiumDrug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, BelgiumThis commentary further reflects on the paper of De Sutter et al. on predicting volume of distribution in neonates, and the performance of physiologically based pharmacokinetic models We hereby stressed the add on value to collaborate on real world data to further close this knowledge gap. We illustrated this by weight distribution characteristics in breastfed (physiology) and in asphyxiated (pathophysiology), with additional reflection on their kidney and liver function.https://www.mdpi.com/1999-4923/16/1/128physiologically based pharmacokinetics (PBPK)pharmacokineticsneonatesvolume of distributionallometric scalingdevelopmental pharmacology |
| spellingShingle | Karel Allegaert Anne Smits Pieter Annaert Interdisciplinary Collaboration on Real World Data to Close the Knowledge Gap: A Reflection on “De Sutter et al. Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling” Pharmaceutics physiologically based pharmacokinetics (PBPK) pharmacokinetics neonates volume of distribution allometric scaling developmental pharmacology |
| title | Interdisciplinary Collaboration on Real World Data to Close the Knowledge Gap: A Reflection on “De Sutter et al. Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling” |
| title_full | Interdisciplinary Collaboration on Real World Data to Close the Knowledge Gap: A Reflection on “De Sutter et al. Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling” |
| title_fullStr | Interdisciplinary Collaboration on Real World Data to Close the Knowledge Gap: A Reflection on “De Sutter et al. Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling” |
| title_full_unstemmed | Interdisciplinary Collaboration on Real World Data to Close the Knowledge Gap: A Reflection on “De Sutter et al. Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling” |
| title_short | Interdisciplinary Collaboration on Real World Data to Close the Knowledge Gap: A Reflection on “De Sutter et al. Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling” |
| title_sort | interdisciplinary collaboration on real world data to close the knowledge gap a reflection on de sutter et al predicting volume of distribution in neonates performance of physiologically based pharmacokinetic modelling |
| topic | physiologically based pharmacokinetics (PBPK) pharmacokinetics neonates volume of distribution allometric scaling developmental pharmacology |
| url | https://www.mdpi.com/1999-4923/16/1/128 |
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