Roles of Nrf2 in Protecting the Kidney from Oxidative Damage
Over 10% of the global population suffers from kidney disease. However, only kidney replacement therapies, which burden medical expenses, are currently effective in treating kidney disease. Therefore, elucidating the complicated molecular pathology of kidney disease is an urgent priority for develop...
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| Format: | Article |
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MDPI AG
2020-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/8/2951 |
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| author | Masahiro Nezu Norio Suzuki |
| author_facet | Masahiro Nezu Norio Suzuki |
| author_sort | Masahiro Nezu |
| collection | DOAJ |
| description | Over 10% of the global population suffers from kidney disease. However, only kidney replacement therapies, which burden medical expenses, are currently effective in treating kidney disease. Therefore, elucidating the complicated molecular pathology of kidney disease is an urgent priority for developing innovative therapeutics for kidney disease. Recent studies demonstrated that intertwined renal vasculature often causes ischemia-reperfusion injury (IRI), which generates oxidative stress, and that the accumulation of oxidative stress is a common pathway underlying various types of kidney disease. We reported that activating the antioxidative transcription factor Nrf2 in renal tubules in mice with renal IRI effectively mitigates tubular damage and interstitial fibrosis by inducing the expression of genes related to cytoprotection against oxidative stress. Additionally, since the kidney performs multiple functions beyond blood purification, renoprotection by Nrf2 activation is anticipated to lead to various benefits. Indeed, our experiments indicated the possibility that Nrf2 activation mitigates anemia, which is caused by impaired production of the erythroid growth factor erythropoietin from injured kidneys, and moderates organ damage worsened by anemic hypoxia. Clinical trials investigating Nrf2-activating compounds in kidney disease patients are ongoing, and beneficial effects are being obtained. Thus, Nrf2 activators are expected to emerge as first-in-class innovative medicine for kidney disease treatment. |
| first_indexed | 2024-03-10T20:18:40Z |
| format | Article |
| id | doaj.art-bac00e53294c4e0b94c9bc2a76932118 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:18:40Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-bac00e53294c4e0b94c9bc2a769321182023-11-19T22:22:07ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01218295110.3390/ijms21082951Roles of Nrf2 in Protecting the Kidney from Oxidative DamageMasahiro Nezu0Norio Suzuki1Department of Endocrinology and Diabetes, Yamanashi Prefectural Central Hospital, Fujimi 1-1-1, Kofu, JapanDivision of Oxygen Biology, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Seiryo-machi 2-1, Aoba-ku, Sendai, JapanOver 10% of the global population suffers from kidney disease. However, only kidney replacement therapies, which burden medical expenses, are currently effective in treating kidney disease. Therefore, elucidating the complicated molecular pathology of kidney disease is an urgent priority for developing innovative therapeutics for kidney disease. Recent studies demonstrated that intertwined renal vasculature often causes ischemia-reperfusion injury (IRI), which generates oxidative stress, and that the accumulation of oxidative stress is a common pathway underlying various types of kidney disease. We reported that activating the antioxidative transcription factor Nrf2 in renal tubules in mice with renal IRI effectively mitigates tubular damage and interstitial fibrosis by inducing the expression of genes related to cytoprotection against oxidative stress. Additionally, since the kidney performs multiple functions beyond blood purification, renoprotection by Nrf2 activation is anticipated to lead to various benefits. Indeed, our experiments indicated the possibility that Nrf2 activation mitigates anemia, which is caused by impaired production of the erythroid growth factor erythropoietin from injured kidneys, and moderates organ damage worsened by anemic hypoxia. Clinical trials investigating Nrf2-activating compounds in kidney disease patients are ongoing, and beneficial effects are being obtained. Thus, Nrf2 activators are expected to emerge as first-in-class innovative medicine for kidney disease treatment.https://www.mdpi.com/1422-0067/21/8/2951ischemia-reperfusion injurychronic kidney diseaseNrf2-activating compoundserythropoietinkidney fibrosis |
| spellingShingle | Masahiro Nezu Norio Suzuki Roles of Nrf2 in Protecting the Kidney from Oxidative Damage International Journal of Molecular Sciences ischemia-reperfusion injury chronic kidney disease Nrf2-activating compounds erythropoietin kidney fibrosis |
| title | Roles of Nrf2 in Protecting the Kidney from Oxidative Damage |
| title_full | Roles of Nrf2 in Protecting the Kidney from Oxidative Damage |
| title_fullStr | Roles of Nrf2 in Protecting the Kidney from Oxidative Damage |
| title_full_unstemmed | Roles of Nrf2 in Protecting the Kidney from Oxidative Damage |
| title_short | Roles of Nrf2 in Protecting the Kidney from Oxidative Damage |
| title_sort | roles of nrf2 in protecting the kidney from oxidative damage |
| topic | ischemia-reperfusion injury chronic kidney disease Nrf2-activating compounds erythropoietin kidney fibrosis |
| url | https://www.mdpi.com/1422-0067/21/8/2951 |
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