Cardiovascular risk estimated by UKPDS risk engine algorithm in diabetes

Since there is a high prevalence of type 2 diabetes mellitus (DM2), as well as CVD in Montenegro, we aimed to estimate CVD risk by United Kingdom Prospective Diabetes Study (UKPDS) risk engine algorithm in individuals with DM2. Furthermore, we aimed to explore whether non-traditional biomarker such...

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Main Authors: Kavaric Nebojsa, Klisic Aleksandra, Ninic Ana
Format: Article
Language:English
Published: De Gruyter 2018-12-01
Series:Open Medicine
Subjects:
Online Access:https://doi.org/10.1515/med-2018-0086
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author Kavaric Nebojsa
Klisic Aleksandra
Ninic Ana
author_facet Kavaric Nebojsa
Klisic Aleksandra
Ninic Ana
author_sort Kavaric Nebojsa
collection DOAJ
description Since there is a high prevalence of type 2 diabetes mellitus (DM2), as well as CVD in Montenegro, we aimed to estimate CVD risk by United Kingdom Prospective Diabetes Study (UKPDS) risk engine algorithm in individuals with DM2. Furthermore, we aimed to explore whether non-traditional biomarker such as high sensitivity C-reactive protein (hsCRP) is superior for CVD risk prediction over old traditional risk factors. A total of 180 participants with DM2 (of them 50% females) were included in the current cross-sectional study. Biochemical and anthropometric parameters, and blood pressure were obtained. More males than females were classified at high UKPDS risk category (p<0.001). Also, about one third of diabetic patients (29.4%) were classified into the high-risk category. In multivariate regression analysis, triglycerides [Odds ratio (OR) =1.703, p=0.001] and creatinine concentration (OR=1.040, p<0.001) were independent predictors of CVD risk, whereas hsCRP was not correlated with CVD risk. HsCRP is not superior for CVD risk prediction by UKPDS risk engine algorithm over high triglyceride and creatinine levels in diabetic population, which suggests that the old traditional markers must not be underestimated when examining CVD risk in population with diabetes.
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spelling doaj.art-bac0a4b1e72b429c8bf2951d452b292b2022-12-21T21:47:19ZengDe GruyterOpen Medicine2391-54632018-12-0113161061710.1515/med-2018-0086med-2018-0086Cardiovascular risk estimated by UKPDS risk engine algorithm in diabetesKavaric Nebojsa0Klisic Aleksandra1Ninic Ana2Primary Health Care Center, Podgorica, MontenegroCenter for Laboratory Diagnostics, Primary Health Care Center, Trg Nikole Kovacevica 6, 81000Podgorica, MontenegroDepartment for Medical Biochemistry, University of Belgrade - Faculty of Pharmacy, Belgrade, SerbiaSince there is a high prevalence of type 2 diabetes mellitus (DM2), as well as CVD in Montenegro, we aimed to estimate CVD risk by United Kingdom Prospective Diabetes Study (UKPDS) risk engine algorithm in individuals with DM2. Furthermore, we aimed to explore whether non-traditional biomarker such as high sensitivity C-reactive protein (hsCRP) is superior for CVD risk prediction over old traditional risk factors. A total of 180 participants with DM2 (of them 50% females) were included in the current cross-sectional study. Biochemical and anthropometric parameters, and blood pressure were obtained. More males than females were classified at high UKPDS risk category (p<0.001). Also, about one third of diabetic patients (29.4%) were classified into the high-risk category. In multivariate regression analysis, triglycerides [Odds ratio (OR) =1.703, p=0.001] and creatinine concentration (OR=1.040, p<0.001) were independent predictors of CVD risk, whereas hsCRP was not correlated with CVD risk. HsCRP is not superior for CVD risk prediction by UKPDS risk engine algorithm over high triglyceride and creatinine levels in diabetic population, which suggests that the old traditional markers must not be underestimated when examining CVD risk in population with diabetes.https://doi.org/10.1515/med-2018-0086cardiovascular risktype 2 diabetesukpds risk engine
spellingShingle Kavaric Nebojsa
Klisic Aleksandra
Ninic Ana
Cardiovascular risk estimated by UKPDS risk engine algorithm in diabetes
Open Medicine
cardiovascular risk
type 2 diabetes
ukpds risk engine
title Cardiovascular risk estimated by UKPDS risk engine algorithm in diabetes
title_full Cardiovascular risk estimated by UKPDS risk engine algorithm in diabetes
title_fullStr Cardiovascular risk estimated by UKPDS risk engine algorithm in diabetes
title_full_unstemmed Cardiovascular risk estimated by UKPDS risk engine algorithm in diabetes
title_short Cardiovascular risk estimated by UKPDS risk engine algorithm in diabetes
title_sort cardiovascular risk estimated by ukpds risk engine algorithm in diabetes
topic cardiovascular risk
type 2 diabetes
ukpds risk engine
url https://doi.org/10.1515/med-2018-0086
work_keys_str_mv AT kavaricnebojsa cardiovascularriskestimatedbyukpdsriskenginealgorithmindiabetes
AT klisicaleksandra cardiovascularriskestimatedbyukpdsriskenginealgorithmindiabetes
AT ninicana cardiovascularriskestimatedbyukpdsriskenginealgorithmindiabetes