Melanogenesis and the Targeted Therapy of Melanoma
Pigment production is a unique character of melanocytes. Numerous factors are linked with melanin production, including genetics, ultraviolet radiation (UVR) and inflammation. Understanding the mechanism of melanogenesis is crucial to identify new preventive and therapeutic strategies in the treatme...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/12/12/1874 |
| _version_ | 1797461236275740672 |
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| author | Cang Li Le Kuai Rutao Cui Xiao Miao |
| author_facet | Cang Li Le Kuai Rutao Cui Xiao Miao |
| author_sort | Cang Li |
| collection | DOAJ |
| description | Pigment production is a unique character of melanocytes. Numerous factors are linked with melanin production, including genetics, ultraviolet radiation (UVR) and inflammation. Understanding the mechanism of melanogenesis is crucial to identify new preventive and therapeutic strategies in the treatment of melanoma. Here, we reviewed the current available literatures on the mechanisms of melanogenesis, including the signaling pathways of UVR-induced pigment production, MC1R’s central determinant roles and MITF as a master transcriptional regulator in melanogenesis. Moreover, we further highlighted the role of targeting BRAF, NRAS and MC1R in melanoma prevention and treatment. The combination therapeutics of immunotherapy and targeted kinase inhibitors are becoming the newest therapeutic option in advanced melanoma. |
| first_indexed | 2024-03-09T17:16:32Z |
| format | Article |
| id | doaj.art-bac2a21f90864a5687eaf5cc988eb6bb |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T17:16:32Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-bac2a21f90864a5687eaf5cc988eb6bb2023-11-24T13:34:53ZengMDPI AGBiomolecules2218-273X2022-12-011212187410.3390/biom12121874Melanogenesis and the Targeted Therapy of MelanomaCang Li0Le Kuai1Rutao Cui2Xiao Miao3Skin Disease Research Institute, Zhejiang University School of Medicine, Hangzhou 310058, ChinaDepartment of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, ChinaSkin Disease Research Institute, Zhejiang University School of Medicine, Hangzhou 310058, ChinaDepartment of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, ChinaPigment production is a unique character of melanocytes. Numerous factors are linked with melanin production, including genetics, ultraviolet radiation (UVR) and inflammation. Understanding the mechanism of melanogenesis is crucial to identify new preventive and therapeutic strategies in the treatment of melanoma. Here, we reviewed the current available literatures on the mechanisms of melanogenesis, including the signaling pathways of UVR-induced pigment production, MC1R’s central determinant roles and MITF as a master transcriptional regulator in melanogenesis. Moreover, we further highlighted the role of targeting BRAF, NRAS and MC1R in melanoma prevention and treatment. The combination therapeutics of immunotherapy and targeted kinase inhibitors are becoming the newest therapeutic option in advanced melanoma.https://www.mdpi.com/2218-273X/12/12/1874melanomamelaninthe targeted therapy of melanoma |
| spellingShingle | Cang Li Le Kuai Rutao Cui Xiao Miao Melanogenesis and the Targeted Therapy of Melanoma Biomolecules melanoma melanin the targeted therapy of melanoma |
| title | Melanogenesis and the Targeted Therapy of Melanoma |
| title_full | Melanogenesis and the Targeted Therapy of Melanoma |
| title_fullStr | Melanogenesis and the Targeted Therapy of Melanoma |
| title_full_unstemmed | Melanogenesis and the Targeted Therapy of Melanoma |
| title_short | Melanogenesis and the Targeted Therapy of Melanoma |
| title_sort | melanogenesis and the targeted therapy of melanoma |
| topic | melanoma melanin the targeted therapy of melanoma |
| url | https://www.mdpi.com/2218-273X/12/12/1874 |
| work_keys_str_mv | AT cangli melanogenesisandthetargetedtherapyofmelanoma AT lekuai melanogenesisandthetargetedtherapyofmelanoma AT rutaocui melanogenesisandthetargetedtherapyofmelanoma AT xiaomiao melanogenesisandthetargetedtherapyofmelanoma |