Use of catheter with 2-methacryloyloxyethyl phosphorylcholine polymer coating is associated with long-term availability of central venous port
Abstract Central venous port (CVP) is a widely used totally implantable venous access device. Recognition of risks associated with CVP-related complications is clinically important for safe, reliable, and long-term intravenous access. We therefore investigated factors associated with CVP infection a...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-84885-4 |
| _version_ | 1818421483701010432 |
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| author | Yuuki Iida Kumiko Hongo Takanobu Onoda Yusuke Kita Yukio Ishihara Naoki Takabayashi Ryo Kobayashi Takeyuki Hiramatsu |
| author_facet | Yuuki Iida Kumiko Hongo Takanobu Onoda Yusuke Kita Yukio Ishihara Naoki Takabayashi Ryo Kobayashi Takeyuki Hiramatsu |
| author_sort | Yuuki Iida |
| collection | DOAJ |
| description | Abstract Central venous port (CVP) is a widely used totally implantable venous access device. Recognition of risks associated with CVP-related complications is clinically important for safe, reliable, and long-term intravenous access. We therefore investigated factors associated with CVP infection and evulsion, including the device type. A total of 308 consecutive patients with initial CVP implantation between January 2011 and December 2017 were retrospectively reviewed, and the association of clinical features with CVP-related complications were analyzed. Intraoperative and postoperative complications occurred in 11 (3.6%) and 39 (12.7%) patients, respectively. The overall rate of CVP availability at six months was 91.4%. Malignancy and 2-Methacryloyloxyethyl phosphorylcholine (MPC) polymer-coated catheter use were negatively associated with the incidence of CVP infections. Accordingly, malignancy and MPC polymer-coated catheter use were independent predictors for lower CVP evulsion rate (odds ratio, 0.23 and 0.18, respectively). Furthermore, both factors were significantly associated with longer CVP availability (hazard ratio, 0.24 and 0.27, respectively). This retrospective study identified factors associated with CVP-related complications and long-term CVP availability. Notably, MPC polymer-coated catheter use was significantly associated with a lower rate of CVP infection and longer CVP availability, suggesting the preventive effect of MPC coating on CVP infection. |
| first_indexed | 2024-12-14T13:11:05Z |
| format | Article |
| id | doaj.art-bac3800431be4e28a6d87007f99403b3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T13:11:05Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-bac3800431be4e28a6d87007f99403b32022-12-21T23:00:12ZengNature PortfolioScientific Reports2045-23222021-03-011111610.1038/s41598-021-84885-4Use of catheter with 2-methacryloyloxyethyl phosphorylcholine polymer coating is associated with long-term availability of central venous portYuuki Iida0Kumiko Hongo1Takanobu Onoda2Yusuke Kita3Yukio Ishihara4Naoki Takabayashi5Ryo Kobayashi6Takeyuki Hiramatsu7Department of Surgery, Yaizu City HospitalDepartment of Surgery, Yaizu City HospitalDepartment of Surgery, Yaizu City HospitalDepartment of Surgery, Yaizu City HospitalDepartment of Surgery, Yaizu City HospitalDepartment of Surgery, Yaizu City HospitalDepartment of Surgery, Yaizu City HospitalDepartment of Surgery, Yaizu City HospitalAbstract Central venous port (CVP) is a widely used totally implantable venous access device. Recognition of risks associated with CVP-related complications is clinically important for safe, reliable, and long-term intravenous access. We therefore investigated factors associated with CVP infection and evulsion, including the device type. A total of 308 consecutive patients with initial CVP implantation between January 2011 and December 2017 were retrospectively reviewed, and the association of clinical features with CVP-related complications were analyzed. Intraoperative and postoperative complications occurred in 11 (3.6%) and 39 (12.7%) patients, respectively. The overall rate of CVP availability at six months was 91.4%. Malignancy and 2-Methacryloyloxyethyl phosphorylcholine (MPC) polymer-coated catheter use were negatively associated with the incidence of CVP infections. Accordingly, malignancy and MPC polymer-coated catheter use were independent predictors for lower CVP evulsion rate (odds ratio, 0.23 and 0.18, respectively). Furthermore, both factors were significantly associated with longer CVP availability (hazard ratio, 0.24 and 0.27, respectively). This retrospective study identified factors associated with CVP-related complications and long-term CVP availability. Notably, MPC polymer-coated catheter use was significantly associated with a lower rate of CVP infection and longer CVP availability, suggesting the preventive effect of MPC coating on CVP infection.https://doi.org/10.1038/s41598-021-84885-4 |
| spellingShingle | Yuuki Iida Kumiko Hongo Takanobu Onoda Yusuke Kita Yukio Ishihara Naoki Takabayashi Ryo Kobayashi Takeyuki Hiramatsu Use of catheter with 2-methacryloyloxyethyl phosphorylcholine polymer coating is associated with long-term availability of central venous port Scientific Reports |
| title | Use of catheter with 2-methacryloyloxyethyl phosphorylcholine polymer coating is associated with long-term availability of central venous port |
| title_full | Use of catheter with 2-methacryloyloxyethyl phosphorylcholine polymer coating is associated with long-term availability of central venous port |
| title_fullStr | Use of catheter with 2-methacryloyloxyethyl phosphorylcholine polymer coating is associated with long-term availability of central venous port |
| title_full_unstemmed | Use of catheter with 2-methacryloyloxyethyl phosphorylcholine polymer coating is associated with long-term availability of central venous port |
| title_short | Use of catheter with 2-methacryloyloxyethyl phosphorylcholine polymer coating is associated with long-term availability of central venous port |
| title_sort | use of catheter with 2 methacryloyloxyethyl phosphorylcholine polymer coating is associated with long term availability of central venous port |
| url | https://doi.org/10.1038/s41598-021-84885-4 |
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