Diclofenac Loaded Biodegradable Nanoparticles as Antitumoral and Antiangiogenic Therapy
Cancer is identified as one of the main causes of death worldwide, and an effective treatment that can reduce/eliminate serious adverse effects is still an unmet medical need. Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), has demonstrated promising antitumoral properties. However, the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/1/102 |
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| author | Gerard Esteruelas Eliana B. Souto Marta Espina María Luisa García Marta Świtalska Joanna Wietrzyk Anna Gliszczyńska Elena Sánchez-López |
| author_facet | Gerard Esteruelas Eliana B. Souto Marta Espina María Luisa García Marta Świtalska Joanna Wietrzyk Anna Gliszczyńska Elena Sánchez-López |
| author_sort | Gerard Esteruelas |
| collection | DOAJ |
| description | Cancer is identified as one of the main causes of death worldwide, and an effective treatment that can reduce/eliminate serious adverse effects is still an unmet medical need. Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), has demonstrated promising antitumoral properties. However, the prolonged use of this NSAID poses several adverse effects. These can be overcome by the use of suitable delivery systems that are able to provide a controlled delivery of the payload. In this study, Diclofenac was incorporated into biodegradable polymeric nanoparticles based on PLGA and the formulation was optimized using a factorial design approach. A monodisperse nanoparticle population was obtained with a mean size of ca. 150 nm and negative surface charge. The release profile of diclofenac from the optimal formulation followed a prolonged release kinetics. Diclofenac nanoparticles demonstrated antitumoral and antiangiogenic properties without causing cytotoxicity to non-tumoral cells, and can be pointed out as a safe, promising and innovative nanoparticle-based formulation with potential antitumoral effects. |
| first_indexed | 2024-03-09T11:28:46Z |
| format | Article |
| id | doaj.art-bac3e0f8aa4f405a84c3466d2cce99b4 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T11:28:46Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-bac3e0f8aa4f405a84c3466d2cce99b42023-11-30T23:57:40ZengMDPI AGPharmaceutics1999-49232022-12-0115110210.3390/pharmaceutics15010102Diclofenac Loaded Biodegradable Nanoparticles as Antitumoral and Antiangiogenic TherapyGerard Esteruelas0Eliana B. Souto1Marta Espina2María Luisa García3Marta Świtalska4Joanna Wietrzyk5Anna Gliszczyńska6Elena Sánchez-López7Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08007 Barcelona, SpainDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, 4050-313 Porto, PortugalDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08007 Barcelona, SpainDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08007 Barcelona, SpainDepartment of Experimental Oncology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wrocław, PolandDepartment of Experimental Oncology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wrocław, PolandDepartment of Food Chemistry and Biocatalysis, Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, PolandDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08007 Barcelona, SpainCancer is identified as one of the main causes of death worldwide, and an effective treatment that can reduce/eliminate serious adverse effects is still an unmet medical need. Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), has demonstrated promising antitumoral properties. However, the prolonged use of this NSAID poses several adverse effects. These can be overcome by the use of suitable delivery systems that are able to provide a controlled delivery of the payload. In this study, Diclofenac was incorporated into biodegradable polymeric nanoparticles based on PLGA and the formulation was optimized using a factorial design approach. A monodisperse nanoparticle population was obtained with a mean size of ca. 150 nm and negative surface charge. The release profile of diclofenac from the optimal formulation followed a prolonged release kinetics. Diclofenac nanoparticles demonstrated antitumoral and antiangiogenic properties without causing cytotoxicity to non-tumoral cells, and can be pointed out as a safe, promising and innovative nanoparticle-based formulation with potential antitumoral effects.https://www.mdpi.com/1999-4923/15/1/102diclofenacnanoparticlesPLGAanti-inflammatorydrug deliveryanti-angiogenesis |
| spellingShingle | Gerard Esteruelas Eliana B. Souto Marta Espina María Luisa García Marta Świtalska Joanna Wietrzyk Anna Gliszczyńska Elena Sánchez-López Diclofenac Loaded Biodegradable Nanoparticles as Antitumoral and Antiangiogenic Therapy Pharmaceutics diclofenac nanoparticles PLGA anti-inflammatory drug delivery anti-angiogenesis |
| title | Diclofenac Loaded Biodegradable Nanoparticles as Antitumoral and Antiangiogenic Therapy |
| title_full | Diclofenac Loaded Biodegradable Nanoparticles as Antitumoral and Antiangiogenic Therapy |
| title_fullStr | Diclofenac Loaded Biodegradable Nanoparticles as Antitumoral and Antiangiogenic Therapy |
| title_full_unstemmed | Diclofenac Loaded Biodegradable Nanoparticles as Antitumoral and Antiangiogenic Therapy |
| title_short | Diclofenac Loaded Biodegradable Nanoparticles as Antitumoral and Antiangiogenic Therapy |
| title_sort | diclofenac loaded biodegradable nanoparticles as antitumoral and antiangiogenic therapy |
| topic | diclofenac nanoparticles PLGA anti-inflammatory drug delivery anti-angiogenesis |
| url | https://www.mdpi.com/1999-4923/15/1/102 |
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