Vascular targeted nanotherapeutic approach for obesity treatment
Nicole Remaliah Samantha Sibuyi,1 Mervin Meyer,1 Martin Opiyo Onani,2 Amanda Skepu,3 Abram Madimabe Madiehe1 1Department of Science and Technology/Mintek Nanotechnology Innovation Centre, Biolabels Unit, Department of Biotechnology, University of the Western Cape, Bellville, South Africa; 2Organome...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-11-01
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| Series: | International Journal of Nanomedicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/vascular-targeted-nanotherapeutic-approach-for-obesity-treatment-peer-reviewed-article-IJN |
| _version_ | 1818346016224575488 |
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| author | Sibuyi NRS Meyer M Onani MO Skepu A Madiehe AM |
| author_facet | Sibuyi NRS Meyer M Onani MO Skepu A Madiehe AM |
| author_sort | Sibuyi NRS |
| collection | DOAJ |
| description | Nicole Remaliah Samantha Sibuyi,1 Mervin Meyer,1 Martin Opiyo Onani,2 Amanda Skepu,3 Abram Madimabe Madiehe1 1Department of Science and Technology/Mintek Nanotechnology Innovation Centre, Biolabels Unit, Department of Biotechnology, University of the Western Cape, Bellville, South Africa; 2Organometallics and Nanomaterials, Department of Chemistry, University of the Western Cape, Bellville, South Africa; 3Department of Science and Technology/Mintek Nanotechnology Innovation Centre, Biolabels Unit, Advanced Materials Division, Mintek, Johannesburg, South Africa Abstract: Obesity is a global epidemic that poses a serious health concern due to it being a risk factor for life-threatening chronic diseases, such as type 2 diabetes, cancer, and cardiovascular diseases. Pharmacotherapy remains the mainstay for the management of obesity; however, its usefulness is limited due to poor drug efficacy, non-specificity and toxic side effects. Therefore, novel approaches that could provide insights into obesity and obesity-associated diseases as well as development of novel anti-obesity treatment modalities or improvement on the existing drugs are necessary. While the ideal treatment of obesity should involve early intervention in susceptible individuals, targeted nanotherapy potentially provides a fresh perspective that might be better than the current conventional therapies. Independent studies have shown improved drug efficacy by using prohibitin (PHB)-targeted therapy in obese rodents and non-human primates, thus providing a proof of concept that targeted nanotherapy can be a feasible treatment for obesity. This review presents a brief global survey of obesity, its impact on human health, its current treatment and their limitations, and the role of angiogenesis and PHB in the development of obesity. Finally, the role and potential use of nanotechnology coupled with targeted drug delivery in the treatment of obesity are discussed. Keywords: adipose tissue, angiogenesis, nanomedicine, obesity, prohibitin, targeted drug delivery |
| first_indexed | 2024-12-13T17:11:33Z |
| format | Article |
| id | doaj.art-bac45653b0a344fdb0cff2e6848f40d3 |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-13T17:11:33Z |
| publishDate | 2018-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-bac45653b0a344fdb0cff2e6848f40d32022-12-21T23:37:33ZengDove Medical PressInternational Journal of Nanomedicine1178-20132018-11-01Volume 137915792942569Vascular targeted nanotherapeutic approach for obesity treatmentSibuyi NRSMeyer MOnani MOSkepu AMadiehe AMNicole Remaliah Samantha Sibuyi,1 Mervin Meyer,1 Martin Opiyo Onani,2 Amanda Skepu,3 Abram Madimabe Madiehe1 1Department of Science and Technology/Mintek Nanotechnology Innovation Centre, Biolabels Unit, Department of Biotechnology, University of the Western Cape, Bellville, South Africa; 2Organometallics and Nanomaterials, Department of Chemistry, University of the Western Cape, Bellville, South Africa; 3Department of Science and Technology/Mintek Nanotechnology Innovation Centre, Biolabels Unit, Advanced Materials Division, Mintek, Johannesburg, South Africa Abstract: Obesity is a global epidemic that poses a serious health concern due to it being a risk factor for life-threatening chronic diseases, such as type 2 diabetes, cancer, and cardiovascular diseases. Pharmacotherapy remains the mainstay for the management of obesity; however, its usefulness is limited due to poor drug efficacy, non-specificity and toxic side effects. Therefore, novel approaches that could provide insights into obesity and obesity-associated diseases as well as development of novel anti-obesity treatment modalities or improvement on the existing drugs are necessary. While the ideal treatment of obesity should involve early intervention in susceptible individuals, targeted nanotherapy potentially provides a fresh perspective that might be better than the current conventional therapies. Independent studies have shown improved drug efficacy by using prohibitin (PHB)-targeted therapy in obese rodents and non-human primates, thus providing a proof of concept that targeted nanotherapy can be a feasible treatment for obesity. This review presents a brief global survey of obesity, its impact on human health, its current treatment and their limitations, and the role of angiogenesis and PHB in the development of obesity. Finally, the role and potential use of nanotechnology coupled with targeted drug delivery in the treatment of obesity are discussed. Keywords: adipose tissue, angiogenesis, nanomedicine, obesity, prohibitin, targeted drug deliveryhttps://www.dovepress.com/vascular-targeted-nanotherapeutic-approach-for-obesity-treatment-peer-reviewed-article-IJNAdipose TissueAngiogenesisNanomedicineObesityProhibitinTargeted drug delivery |
| spellingShingle | Sibuyi NRS Meyer M Onani MO Skepu A Madiehe AM Vascular targeted nanotherapeutic approach for obesity treatment International Journal of Nanomedicine Adipose Tissue Angiogenesis Nanomedicine Obesity Prohibitin Targeted drug delivery |
| title | Vascular targeted nanotherapeutic approach for obesity treatment |
| title_full | Vascular targeted nanotherapeutic approach for obesity treatment |
| title_fullStr | Vascular targeted nanotherapeutic approach for obesity treatment |
| title_full_unstemmed | Vascular targeted nanotherapeutic approach for obesity treatment |
| title_short | Vascular targeted nanotherapeutic approach for obesity treatment |
| title_sort | vascular targeted nanotherapeutic approach for obesity treatment |
| topic | Adipose Tissue Angiogenesis Nanomedicine Obesity Prohibitin Targeted drug delivery |
| url | https://www.dovepress.com/vascular-targeted-nanotherapeutic-approach-for-obesity-treatment-peer-reviewed-article-IJN |
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