Synthesis, pharmacological evaluation, and molecular modeling studies of novel isatin hybrids as potential anticancer agents

Synthesis, pharmacological evaluation, and molecular modeling studies of novel isatin hybrids as potential anticancer agents

A novel series of isatin hybrids 5a-g was designed, synthesized, and characterized spectroscopically. The synthesized compounds were evaluated for their cytotoxic activity against the human breast cancer cell line (MCF-7) by in vitro MTT assay. Amongst the tested compounds, 5e compound bearing benzy...

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Bibliographic Details
Main Authors:	Rajapandi Raju, Kumarappan Chidambaram, Balakumar Chandrasekaran, Mohammad F. Bayan, Tapan Kumar Maity, Abdullah M. Alkahtani, Harish C Chandramoorthy
Format:	Article
Language:	English
Published:	Elsevier 2023-03-01
Series:	Journal of Saudi Chemical Society
Subjects:	Isatin-pyrimidine hybrid Antiproliferative activity Breast cancer cell (MCF-7) Dalton’s ascitic lymphoma (DAL) Molecular docking
Online Access:	http://www.sciencedirect.com/science/article/pii/S1319610323000029

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