Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts
Rapid population aging has led to a global burden of late-life diseases. As the largest risk factor for a multitude of age-related diseases, aging is not only the result of genotype but also closely related to external factors. With the rapid expansion in the usage of electromagnetic fields (EMFs),...
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2021.761069/full |
| _version_ | 1818826693037522944 |
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| author | Chuan Sun Zheng Huang Houbing Qin Jing Zhang Sanying Wang Xiaogang Xu Shibo Ying Genxiang Mao |
| author_facet | Chuan Sun Zheng Huang Houbing Qin Jing Zhang Sanying Wang Xiaogang Xu Shibo Ying Genxiang Mao |
| author_sort | Chuan Sun |
| collection | DOAJ |
| description | Rapid population aging has led to a global burden of late-life diseases. As the largest risk factor for a multitude of age-related diseases, aging is not only the result of genotype but also closely related to external factors. With the rapid expansion in the usage of electromagnetic fields (EMFs), the effect of EMFs on aging has also attracted attention. Cells are the basic unit of organs and body tissues, and cellular senescence plays an important role in the aging process. The effect of EMFs on cellular senescence has been investigated in a few studies, but the information is limited, and the results are inconsistent; thus, further investigation is required. In this study, we investigated the effect of 10 Hz pulsed magnetic fields (MFs) on cellular senescence in a 2BS cell line, isolated from human fetal lung fibroblasts, and found that intermittent (1 d on/1 d off) exposure to 10 Hz pulsed MFs at 1.0 mT for 2 weeks induced DNA damage, but no other significant phenotype of cellular senescence in 2BS cells. |
| first_indexed | 2024-12-19T00:31:43Z |
| format | Article |
| id | doaj.art-bac5254e1b5d4158b6465bb432750f46 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-12-19T00:31:43Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Public Health |
| spelling | doaj.art-bac5254e1b5d4158b6465bb432750f462022-12-21T20:45:05ZengFrontiers Media S.A.Frontiers in Public Health2296-25652021-11-01910.3389/fpubh.2021.761069761069Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung FibroblastsChuan Sun0Zheng Huang1Houbing Qin2Jing Zhang3Sanying Wang4Xiaogang Xu5Shibo Ying6Genxiang Mao7Zhejiang Provincial Key Lab of Geriatrics and Geriatrics Institute of Zhejiang Province, Department of Geriatrics, Zhejiang Hospital, Hangzhou, ChinaSchool of Stomatology, Hangzhou Normal University, Hangzhou, ChinaDepartment of Respiratory Medicine, Children's Hospital of Nanjing Medical University, Nanjing, ChinaZhejiang Provincial Key Lab of Geriatrics and Geriatrics Institute of Zhejiang Province, Department of Geriatrics, Zhejiang Hospital, Hangzhou, ChinaZhejiang Provincial Key Lab of Geriatrics and Geriatrics Institute of Zhejiang Province, Department of Geriatrics, Zhejiang Hospital, Hangzhou, ChinaZhejiang Provincial Key Lab of Geriatrics and Geriatrics Institute of Zhejiang Province, Department of Geriatrics, Zhejiang Hospital, Hangzhou, ChinaHangzhou Medical College, Hangzhou, ChinaZhejiang Provincial Key Lab of Geriatrics and Geriatrics Institute of Zhejiang Province, Department of Geriatrics, Zhejiang Hospital, Hangzhou, ChinaRapid population aging has led to a global burden of late-life diseases. As the largest risk factor for a multitude of age-related diseases, aging is not only the result of genotype but also closely related to external factors. With the rapid expansion in the usage of electromagnetic fields (EMFs), the effect of EMFs on aging has also attracted attention. Cells are the basic unit of organs and body tissues, and cellular senescence plays an important role in the aging process. The effect of EMFs on cellular senescence has been investigated in a few studies, but the information is limited, and the results are inconsistent; thus, further investigation is required. In this study, we investigated the effect of 10 Hz pulsed magnetic fields (MFs) on cellular senescence in a 2BS cell line, isolated from human fetal lung fibroblasts, and found that intermittent (1 d on/1 d off) exposure to 10 Hz pulsed MFs at 1.0 mT for 2 weeks induced DNA damage, but no other significant phenotype of cellular senescence in 2BS cells.https://www.frontiersin.org/articles/10.3389/fpubh.2021.761069/fullelectromagnetic fields (EMFs)agingDNA damagepulsed electromagnetic fieldcellular senescencehuman fetal lung fibroblasts |
| spellingShingle | Chuan Sun Zheng Huang Houbing Qin Jing Zhang Sanying Wang Xiaogang Xu Shibo Ying Genxiang Mao Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts Frontiers in Public Health electromagnetic fields (EMFs) aging DNA damage pulsed electromagnetic field cellular senescence human fetal lung fibroblasts |
| title | Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts |
| title_full | Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts |
| title_fullStr | Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts |
| title_full_unstemmed | Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts |
| title_short | Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts |
| title_sort | exposure to 10 hz pulsed magnetic fields do not induce cellular senescence in human fetal lung fibroblasts |
| topic | electromagnetic fields (EMFs) aging DNA damage pulsed electromagnetic field cellular senescence human fetal lung fibroblasts |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2021.761069/full |
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