A randomized clinical trial of metacognitive therapy and nortriptyline for anxiety, depression, and difficulties in emotion regulation of patients with functional dyspepsia

Functional Dyspepsia (FD) as a psychosomatic disorder is an upper gastrointestinal tract disease without organic pathogenesis causes. The psychopathological nature of this disease and its high correlation with anxiety and depression implies the need for psychological interventions. The purpose of th...

Full description

Bibliographic Details
Main Authors: Sepideh Batebi, Abbas Masjedi Arani, Mahdi Jafari, Amir Sadeghi, Mohsen Saberi Isfeedvajani, Mohammad Hasan Davazdah Emami
Format: Article
Language:English
Published: PAGEPress Publications 2020-09-01
Series:Research in Psychotherapy
Subjects:
Online Access:https://researchinpsychotherapy.org/index.php/rpsy/article/view/448
_version_ 1828432066841149440
author Sepideh Batebi
Abbas Masjedi Arani
Mahdi Jafari
Amir Sadeghi
Mohsen Saberi Isfeedvajani
Mohammad Hasan Davazdah Emami
author_facet Sepideh Batebi
Abbas Masjedi Arani
Mahdi Jafari
Amir Sadeghi
Mohsen Saberi Isfeedvajani
Mohammad Hasan Davazdah Emami
author_sort Sepideh Batebi
collection DOAJ
description Functional Dyspepsia (FD) as a psychosomatic disorder is an upper gastrointestinal tract disease without organic pathogenesis causes. The psychopathological nature of this disease and its high correlation with anxiety and depression implies the need for psychological interventions. The purpose of the present study is to compare the efficacy of Metacognitive Therapy (MCT) and medication for the symptoms of anxiety, depression, and difficulties in emotion regulation in patients with FD. In a randomized clinical trial, 65 patients with FD were recruited during their visit to gastroenterology clinics. These patients were randomly assigned to three groups to receive MCT, nortriptyline treatment, and controls. They were treated for 10 weeks and followed up three months later. The instruments used in this study were Hamilton anxiety and Depression Rating Scale (HAM-A and HDRS) and difficulties in emotion regulation scale. The results were analyzed using repeated measure analysis by SPSS (19- IBM). Data analysis showed statistically significant differences in the variables of depression, anxiety among MCT, nortriptyline treatment, and controls at pre-test, post-test and follow-up phases. Moreover, MCT had a better and more persistent effect on anxiety compared to nortriptyline treatment, as well as a better efficacy in treating anxiety and depression symptoms compared to the controls. MCT demonstrated better efficacy in treating anxiety symptoms compared to nortriptyline treatment and controls.
first_indexed 2024-12-10T18:13:07Z
format Article
id doaj.art-bac5c651c869483ba68adc6f8105f6f9
institution Directory Open Access Journal
issn 2499-7552
2239-8031
language English
last_indexed 2024-12-10T18:13:07Z
publishDate 2020-09-01
publisher PAGEPress Publications
record_format Article
series Research in Psychotherapy
spelling doaj.art-bac5c651c869483ba68adc6f8105f6f92022-12-22T01:38:23ZengPAGEPress PublicationsResearch in Psychotherapy2499-75522239-80312020-09-0123210.4081/ripppo.2020.448A randomized clinical trial of metacognitive therapy and nortriptyline for anxiety, depression, and difficulties in emotion regulation of patients with functional dyspepsiaSepideh Batebi0Abbas Masjedi Arani1Mahdi Jafari2Amir Sadeghi3Mohsen Saberi Isfeedvajani4Mohammad Hasan Davazdah Emami5Department of Clinical Psychology, Faculty of Medicine, Shahid Beheshti University of Medical SciencesDepartment of Clinical Psychology, Faculty of Medicine, Shahid Beheshti University of Medical SciencesDepartment of Clinical Psychology, Faculty of Medicine, Shahid Beheshti University of Medical SciencesGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases. Shahid Beheshti University of Medical SciencesMedicine, Quran and Hadith Research Center & Department of Community Medicine, Faculty of Medicine, Baqiyatallah University of Medical Sciences, TehranDepartment of Health Psychology, Isfahan University of Medical Science, IsfahanFunctional Dyspepsia (FD) as a psychosomatic disorder is an upper gastrointestinal tract disease without organic pathogenesis causes. The psychopathological nature of this disease and its high correlation with anxiety and depression implies the need for psychological interventions. The purpose of the present study is to compare the efficacy of Metacognitive Therapy (MCT) and medication for the symptoms of anxiety, depression, and difficulties in emotion regulation in patients with FD. In a randomized clinical trial, 65 patients with FD were recruited during their visit to gastroenterology clinics. These patients were randomly assigned to three groups to receive MCT, nortriptyline treatment, and controls. They were treated for 10 weeks and followed up three months later. The instruments used in this study were Hamilton anxiety and Depression Rating Scale (HAM-A and HDRS) and difficulties in emotion regulation scale. The results were analyzed using repeated measure analysis by SPSS (19- IBM). Data analysis showed statistically significant differences in the variables of depression, anxiety among MCT, nortriptyline treatment, and controls at pre-test, post-test and follow-up phases. Moreover, MCT had a better and more persistent effect on anxiety compared to nortriptyline treatment, as well as a better efficacy in treating anxiety and depression symptoms compared to the controls. MCT demonstrated better efficacy in treating anxiety symptoms compared to nortriptyline treatment and controls.https://researchinpsychotherapy.org/index.php/rpsy/article/view/448dyspepsiapsychotherapyanxietydepressionemotion
spellingShingle Sepideh Batebi
Abbas Masjedi Arani
Mahdi Jafari
Amir Sadeghi
Mohsen Saberi Isfeedvajani
Mohammad Hasan Davazdah Emami
A randomized clinical trial of metacognitive therapy and nortriptyline for anxiety, depression, and difficulties in emotion regulation of patients with functional dyspepsia
Research in Psychotherapy
dyspepsia
psychotherapy
anxiety
depression
emotion
title A randomized clinical trial of metacognitive therapy and nortriptyline for anxiety, depression, and difficulties in emotion regulation of patients with functional dyspepsia
title_full A randomized clinical trial of metacognitive therapy and nortriptyline for anxiety, depression, and difficulties in emotion regulation of patients with functional dyspepsia
title_fullStr A randomized clinical trial of metacognitive therapy and nortriptyline for anxiety, depression, and difficulties in emotion regulation of patients with functional dyspepsia
title_full_unstemmed A randomized clinical trial of metacognitive therapy and nortriptyline for anxiety, depression, and difficulties in emotion regulation of patients with functional dyspepsia
title_short A randomized clinical trial of metacognitive therapy and nortriptyline for anxiety, depression, and difficulties in emotion regulation of patients with functional dyspepsia
title_sort randomized clinical trial of metacognitive therapy and nortriptyline for anxiety depression and difficulties in emotion regulation of patients with functional dyspepsia
topic dyspepsia
psychotherapy
anxiety
depression
emotion
url https://researchinpsychotherapy.org/index.php/rpsy/article/view/448
work_keys_str_mv AT sepidehbatebi arandomizedclinicaltrialofmetacognitivetherapyandnortriptylineforanxietydepressionanddifficultiesinemotionregulationofpatientswithfunctionaldyspepsia
AT abbasmasjediarani arandomizedclinicaltrialofmetacognitivetherapyandnortriptylineforanxietydepressionanddifficultiesinemotionregulationofpatientswithfunctionaldyspepsia
AT mahdijafari arandomizedclinicaltrialofmetacognitivetherapyandnortriptylineforanxietydepressionanddifficultiesinemotionregulationofpatientswithfunctionaldyspepsia
AT amirsadeghi arandomizedclinicaltrialofmetacognitivetherapyandnortriptylineforanxietydepressionanddifficultiesinemotionregulationofpatientswithfunctionaldyspepsia
AT mohsensaberiisfeedvajani arandomizedclinicaltrialofmetacognitivetherapyandnortriptylineforanxietydepressionanddifficultiesinemotionregulationofpatientswithfunctionaldyspepsia
AT mohammadhasandavazdahemami arandomizedclinicaltrialofmetacognitivetherapyandnortriptylineforanxietydepressionanddifficultiesinemotionregulationofpatientswithfunctionaldyspepsia
AT sepidehbatebi randomizedclinicaltrialofmetacognitivetherapyandnortriptylineforanxietydepressionanddifficultiesinemotionregulationofpatientswithfunctionaldyspepsia
AT abbasmasjediarani randomizedclinicaltrialofmetacognitivetherapyandnortriptylineforanxietydepressionanddifficultiesinemotionregulationofpatientswithfunctionaldyspepsia
AT mahdijafari randomizedclinicaltrialofmetacognitivetherapyandnortriptylineforanxietydepressionanddifficultiesinemotionregulationofpatientswithfunctionaldyspepsia
AT amirsadeghi randomizedclinicaltrialofmetacognitivetherapyandnortriptylineforanxietydepressionanddifficultiesinemotionregulationofpatientswithfunctionaldyspepsia
AT mohsensaberiisfeedvajani randomizedclinicaltrialofmetacognitivetherapyandnortriptylineforanxietydepressionanddifficultiesinemotionregulationofpatientswithfunctionaldyspepsia
AT mohammadhasandavazdahemami randomizedclinicaltrialofmetacognitivetherapyandnortriptylineforanxietydepressionanddifficultiesinemotionregulationofpatientswithfunctionaldyspepsia