Antibacterial Activity and Cytotoxicity of Silver(I) Complexes of Pyridine and (Benz)Imidazole Derivatives. X-ray Crystal Structure of [Ag(2,6-di(CH2OH)py)2]NO3
Selected aspects of the biological activity of a series of six nitrate silver(I) complexes with pyridine and (benz)imidazole derivatives were investigated. The present study evaluated the antibacterial activities of the complexes against three Gram-negative strains: Pseudomonas aeruginosa ATCC 15442...
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MDPI AG
2016-01-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/2/87 |
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| author | Urszula Kalinowska-Lis Aleksandra Felczak Lilianna Chęcińska Ilona Szabłowska-Gadomska Emila Patyna Maciej Małecki Katarzyna Lisowska Justyn Ochocki |
| author_facet | Urszula Kalinowska-Lis Aleksandra Felczak Lilianna Chęcińska Ilona Szabłowska-Gadomska Emila Patyna Maciej Małecki Katarzyna Lisowska Justyn Ochocki |
| author_sort | Urszula Kalinowska-Lis |
| collection | DOAJ |
| description | Selected aspects of the biological activity of a series of six nitrate silver(I) complexes with pyridine and (benz)imidazole derivatives were investigated. The present study evaluated the antibacterial activities of the complexes against three Gram-negative strains: Pseudomonas aeruginosa ATCC 15442, Escherichia coli ATCC 25922 and Proteus hauseri ATCC 13315. The results were compared with those of silver nitrate, a silver sulfadiazine drug and appropriate ligands. The most significant antibacterial properties were exerted by silver(I) complexes containing benzimidazole derivatives. The cytotoxic activity of the complexes was examined against B16 (murine melanoma) and 10T1/2 (murine fibroblasts) cells. All of the tested silver(I) compounds were not toxic to fibroblast cells in concentration inhibited cancer cell (B16) viability by 50%, which ranged between 2.44–28.65 µM. The molecular and crystal structure of silver(I) complex of 2,6-di(hydroxymethyl)pyridine was determined by single-crystal X-ray diffraction analysis. The most important features of the crystal packing and intermolecular non-covalent interactions in the Ag(I) complex were quantified via Hirshfeld surface analysis. |
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| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-17T08:28:43Z |
| publishDate | 2016-01-01 |
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| series | Molecules |
| spelling | doaj.art-bac650060e724fdeb21866431579616f2022-12-21T21:56:41ZengMDPI AGMolecules1420-30492016-01-012128710.3390/molecules21020087molecules21020087Antibacterial Activity and Cytotoxicity of Silver(I) Complexes of Pyridine and (Benz)Imidazole Derivatives. X-ray Crystal Structure of [Ag(2,6-di(CH2OH)py)2]NO3Urszula Kalinowska-Lis0Aleksandra Felczak1Lilianna Chęcińska2Ilona Szabłowska-Gadomska3Emila Patyna4Maciej Małecki5Katarzyna Lisowska6Justyn Ochocki7Department of Bioinorganic Chemistry, Medical University of Lodz, Muszyńskiego 1, 90-151 Łódź, PolandDepartment of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-237 Łódź, PolandDepartment of Theoretical and Structural Chemistry, University of Lodz, Pomorska 163/165, 90-236 Łódź, PolandDepartment of Applied Pharmacy and Bioengineering, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, PolandDepartment of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-237 Łódź, PolandDepartment of Applied Pharmacy and Bioengineering, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, PolandDepartment of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-237 Łódź, PolandDepartment of Bioinorganic Chemistry, Medical University of Lodz, Muszyńskiego 1, 90-151 Łódź, PolandSelected aspects of the biological activity of a series of six nitrate silver(I) complexes with pyridine and (benz)imidazole derivatives were investigated. The present study evaluated the antibacterial activities of the complexes against three Gram-negative strains: Pseudomonas aeruginosa ATCC 15442, Escherichia coli ATCC 25922 and Proteus hauseri ATCC 13315. The results were compared with those of silver nitrate, a silver sulfadiazine drug and appropriate ligands. The most significant antibacterial properties were exerted by silver(I) complexes containing benzimidazole derivatives. The cytotoxic activity of the complexes was examined against B16 (murine melanoma) and 10T1/2 (murine fibroblasts) cells. All of the tested silver(I) compounds were not toxic to fibroblast cells in concentration inhibited cancer cell (B16) viability by 50%, which ranged between 2.44–28.65 µM. The molecular and crystal structure of silver(I) complex of 2,6-di(hydroxymethyl)pyridine was determined by single-crystal X-ray diffraction analysis. The most important features of the crystal packing and intermolecular non-covalent interactions in the Ag(I) complex were quantified via Hirshfeld surface analysis.http://www.mdpi.com/1420-3049/21/2/87silver(I) complexescytotoxicityB16 melanoma cells10T1/2 fibroblastsantibacterial activityHirshfeld surface |
| spellingShingle | Urszula Kalinowska-Lis Aleksandra Felczak Lilianna Chęcińska Ilona Szabłowska-Gadomska Emila Patyna Maciej Małecki Katarzyna Lisowska Justyn Ochocki Antibacterial Activity and Cytotoxicity of Silver(I) Complexes of Pyridine and (Benz)Imidazole Derivatives. X-ray Crystal Structure of [Ag(2,6-di(CH2OH)py)2]NO3 Molecules silver(I) complexes cytotoxicity B16 melanoma cells 10T1/2 fibroblasts antibacterial activity Hirshfeld surface |
| title | Antibacterial Activity and Cytotoxicity of Silver(I) Complexes of Pyridine and (Benz)Imidazole Derivatives. X-ray Crystal Structure of [Ag(2,6-di(CH2OH)py)2]NO3 |
| title_full | Antibacterial Activity and Cytotoxicity of Silver(I) Complexes of Pyridine and (Benz)Imidazole Derivatives. X-ray Crystal Structure of [Ag(2,6-di(CH2OH)py)2]NO3 |
| title_fullStr | Antibacterial Activity and Cytotoxicity of Silver(I) Complexes of Pyridine and (Benz)Imidazole Derivatives. X-ray Crystal Structure of [Ag(2,6-di(CH2OH)py)2]NO3 |
| title_full_unstemmed | Antibacterial Activity and Cytotoxicity of Silver(I) Complexes of Pyridine and (Benz)Imidazole Derivatives. X-ray Crystal Structure of [Ag(2,6-di(CH2OH)py)2]NO3 |
| title_short | Antibacterial Activity and Cytotoxicity of Silver(I) Complexes of Pyridine and (Benz)Imidazole Derivatives. X-ray Crystal Structure of [Ag(2,6-di(CH2OH)py)2]NO3 |
| title_sort | antibacterial activity and cytotoxicity of silver i complexes of pyridine and benz imidazole derivatives x ray crystal structure of ag 2 6 di ch2oh py 2 no3 |
| topic | silver(I) complexes cytotoxicity B16 melanoma cells 10T1/2 fibroblasts antibacterial activity Hirshfeld surface |
| url | http://www.mdpi.com/1420-3049/21/2/87 |
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