Super-resolution QSM in little or no additional time for imaging (NATIve) using 2D EPI imaging in 3 orthogonal planes
Quantitative Susceptibility Mapping has the potential to provide additional insights into neurological diseases but is typically based on a quite long (5–10 min) 3D gradient-echo scan which is highly sensitive to motion. We propose an ultra-fast acquisition based on three orthogonal (sagittal, coron...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811923005700 |
| _version_ | 1797627357399351296 |
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| author | Beata Bachrata Steffen Bollmann Jin Jin Monique Tourell Assunta Dal-Bianco Siegfried Trattnig Markus Barth Stefan Ropele Christian Enzinger Simon Daniel Robinson |
| author_facet | Beata Bachrata Steffen Bollmann Jin Jin Monique Tourell Assunta Dal-Bianco Siegfried Trattnig Markus Barth Stefan Ropele Christian Enzinger Simon Daniel Robinson |
| author_sort | Beata Bachrata |
| collection | DOAJ |
| description | Quantitative Susceptibility Mapping has the potential to provide additional insights into neurological diseases but is typically based on a quite long (5–10 min) 3D gradient-echo scan which is highly sensitive to motion. We propose an ultra-fast acquisition based on three orthogonal (sagittal, coronal and axial) 2D simultaneous multi-slice EPI scans with 1 mm in-plane resolution and 3 mm thick slices. Images in each orientation are corrected for susceptibility-related distortions and co-registered with an iterative non-linear Minimum Deformation Averaging (Volgenmodel) approach to generate a high SNR, super-resolution data set with an isotropic resolution of close to 1 mm. The net acquisition time is 3 times the volume acquisition time of EPI or about 12 s, but the three volumes could also replace “dummy scans” in fMRI, making it feasible to acquire QSM in little or No Additional Time for Imaging (NATIve). NATIve QSM values agreed well with reference 3D GRE QSM in the basal ganglia in healthy subjects. In patients with multiple sclerosis, there was also a good agreement between the susceptibility values within lesions and control ROIs and all lesions which could be seen on 3D GRE QSMs could also be visualized on NATIve QSMs. The approach is faster than conventional 3D GRE by a factor of 25–50 and faster than 3D EPI by a factor of 3–5. As a 2D technique, NATIve QSM was shown to be much more robust to motion than the 3D GRE and 3D EPI, opening up the possibility of studying neurological diseases involving iron accumulation and demyelination in patients who find it difficult to lie still for long enough to acquire QSM data with conventional methods. |
| first_indexed | 2024-03-11T10:22:59Z |
| format | Article |
| id | doaj.art-bac6ed5b371b45f190003fde770e9620 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-03-11T10:22:59Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-bac6ed5b371b45f190003fde770e96202023-11-16T06:06:00ZengElsevierNeuroImage1095-95722023-12-01283120419Super-resolution QSM in little or no additional time for imaging (NATIve) using 2D EPI imaging in 3 orthogonal planesBeata Bachrata0Steffen Bollmann1Jin Jin2Monique Tourell3Assunta Dal-Bianco4Siegfried Trattnig5Markus Barth6Stefan Ropele7Christian Enzinger8Simon Daniel Robinson9High Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Austria; Karl Landsteiner Institute for Clinical Molecular MR in Musculoskeletal Imaging, Vienna, Austria; Department of Medical Engineering, Carinthia University of Applied Sciences, Klagenfurt, AustriaCentre of Advanced Imaging, University of Queensland, Brisbane, Australia; ARC Training Centre for Innovation in Biomedical Imaging Technology, University of Queensland, Brisbane, Australia; School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, AustraliaCentre of Advanced Imaging, University of Queensland, Brisbane, Australia; Siemens Healthcare Pty Ltd, AustraliaCentre of Advanced Imaging, University of Queensland, Brisbane, Australia; ARC Training Centre for Innovation in Biomedical Imaging Technology, University of Queensland, Brisbane, AustraliaDepartment of Neurology, Medical University of Vienna, Austria; Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, AustriaHigh Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Austria; Karl Landsteiner Institute for Clinical Molecular MR in Musculoskeletal Imaging, Vienna, AustriaCentre of Advanced Imaging, University of Queensland, Brisbane, Australia; ARC Training Centre for Innovation in Biomedical Imaging Technology, University of Queensland, Brisbane, Australia; School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, AustraliaDepartment of Neurology, Medical University of Graz, AustriaDepartment of Neurology, Medical University of Graz, AustriaHigh Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Austria; Centre of Advanced Imaging, University of Queensland, Brisbane, Australia; Department of Neurology, Medical University of Graz, Austria; Corresponding author at: High Field MR Centre, Medical University of Vienna, Lazarettgasse 14/BT32, 1090 Vienna, Austria.Quantitative Susceptibility Mapping has the potential to provide additional insights into neurological diseases but is typically based on a quite long (5–10 min) 3D gradient-echo scan which is highly sensitive to motion. We propose an ultra-fast acquisition based on three orthogonal (sagittal, coronal and axial) 2D simultaneous multi-slice EPI scans with 1 mm in-plane resolution and 3 mm thick slices. Images in each orientation are corrected for susceptibility-related distortions and co-registered with an iterative non-linear Minimum Deformation Averaging (Volgenmodel) approach to generate a high SNR, super-resolution data set with an isotropic resolution of close to 1 mm. The net acquisition time is 3 times the volume acquisition time of EPI or about 12 s, but the three volumes could also replace “dummy scans” in fMRI, making it feasible to acquire QSM in little or No Additional Time for Imaging (NATIve). NATIve QSM values agreed well with reference 3D GRE QSM in the basal ganglia in healthy subjects. In patients with multiple sclerosis, there was also a good agreement between the susceptibility values within lesions and control ROIs and all lesions which could be seen on 3D GRE QSMs could also be visualized on NATIve QSMs. The approach is faster than conventional 3D GRE by a factor of 25–50 and faster than 3D EPI by a factor of 3–5. As a 2D technique, NATIve QSM was shown to be much more robust to motion than the 3D GRE and 3D EPI, opening up the possibility of studying neurological diseases involving iron accumulation and demyelination in patients who find it difficult to lie still for long enough to acquire QSM data with conventional methods.http://www.sciencedirect.com/science/article/pii/S1053811923005700Super-resolution2D EPIQSMNATIveUltra-fastMotion-robust |
| spellingShingle | Beata Bachrata Steffen Bollmann Jin Jin Monique Tourell Assunta Dal-Bianco Siegfried Trattnig Markus Barth Stefan Ropele Christian Enzinger Simon Daniel Robinson Super-resolution QSM in little or no additional time for imaging (NATIve) using 2D EPI imaging in 3 orthogonal planes NeuroImage Super-resolution 2D EPI QSM NATIve Ultra-fast Motion-robust |
| title | Super-resolution QSM in little or no additional time for imaging (NATIve) using 2D EPI imaging in 3 orthogonal planes |
| title_full | Super-resolution QSM in little or no additional time for imaging (NATIve) using 2D EPI imaging in 3 orthogonal planes |
| title_fullStr | Super-resolution QSM in little or no additional time for imaging (NATIve) using 2D EPI imaging in 3 orthogonal planes |
| title_full_unstemmed | Super-resolution QSM in little or no additional time for imaging (NATIve) using 2D EPI imaging in 3 orthogonal planes |
| title_short | Super-resolution QSM in little or no additional time for imaging (NATIve) using 2D EPI imaging in 3 orthogonal planes |
| title_sort | super resolution qsm in little or no additional time for imaging native using 2d epi imaging in 3 orthogonal planes |
| topic | Super-resolution 2D EPI QSM NATIve Ultra-fast Motion-robust |
| url | http://www.sciencedirect.com/science/article/pii/S1053811923005700 |
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