The Role of TGF-β3 in Radiation Response
Transforming growth factor-beta 3 (TGF-β3) is a ubiquitously expressed multifunctional cytokine involved in a range of physiological and pathological conditions, including embryogenesis, cell cycle regulation, immunoregulation, and fibrogenesis. The cytotoxic effects of ionizing radiation are employ...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/8/7614 |
| _version_ | 1797605036523520000 |
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| author | Ingunn Hanson Kathinka E. Pitman Nina F. J. Edin |
| author_facet | Ingunn Hanson Kathinka E. Pitman Nina F. J. Edin |
| author_sort | Ingunn Hanson |
| collection | DOAJ |
| description | Transforming growth factor-beta 3 (TGF-β3) is a ubiquitously expressed multifunctional cytokine involved in a range of physiological and pathological conditions, including embryogenesis, cell cycle regulation, immunoregulation, and fibrogenesis. The cytotoxic effects of ionizing radiation are employed in cancer radiotherapy, but its actions also influence cellular signaling pathways, including that of TGF-β3. Furthermore, the cell cycle regulating and anti-fibrotic effects of TGF-β3 have identified it as a potential mitigator of radiation- and chemotherapy-induced toxicity in healthy tissue. This review discusses the radiobiology of TGF-β3, its induction in tissue by ionizing radiation, and its potential radioprotective and anti-fibrotic effects. |
| first_indexed | 2024-03-11T04:55:25Z |
| format | Article |
| id | doaj.art-bac7256c966d4cfda0004774e70aede8 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:55:25Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-bac7256c966d4cfda0004774e70aede82023-11-17T19:43:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248761410.3390/ijms24087614The Role of TGF-β3 in Radiation ResponseIngunn Hanson0Kathinka E. Pitman1Nina F. J. Edin2Department of Physics, University of Oslo, 0371 Oslo, NorwayDepartment of Physics, University of Oslo, 0371 Oslo, NorwayDepartment of Physics, University of Oslo, 0371 Oslo, NorwayTransforming growth factor-beta 3 (TGF-β3) is a ubiquitously expressed multifunctional cytokine involved in a range of physiological and pathological conditions, including embryogenesis, cell cycle regulation, immunoregulation, and fibrogenesis. The cytotoxic effects of ionizing radiation are employed in cancer radiotherapy, but its actions also influence cellular signaling pathways, including that of TGF-β3. Furthermore, the cell cycle regulating and anti-fibrotic effects of TGF-β3 have identified it as a potential mitigator of radiation- and chemotherapy-induced toxicity in healthy tissue. This review discusses the radiobiology of TGF-β3, its induction in tissue by ionizing radiation, and its potential radioprotective and anti-fibrotic effects.https://www.mdpi.com/1422-0067/24/8/7614cell cycle regulationchemotherapyfibrosisionizing radiationradiomitigationtransforming growth factor beta |
| spellingShingle | Ingunn Hanson Kathinka E. Pitman Nina F. J. Edin The Role of TGF-β3 in Radiation Response International Journal of Molecular Sciences cell cycle regulation chemotherapy fibrosis ionizing radiation radiomitigation transforming growth factor beta |
| title | The Role of TGF-β3 in Radiation Response |
| title_full | The Role of TGF-β3 in Radiation Response |
| title_fullStr | The Role of TGF-β3 in Radiation Response |
| title_full_unstemmed | The Role of TGF-β3 in Radiation Response |
| title_short | The Role of TGF-β3 in Radiation Response |
| title_sort | role of tgf β3 in radiation response |
| topic | cell cycle regulation chemotherapy fibrosis ionizing radiation radiomitigation transforming growth factor beta |
| url | https://www.mdpi.com/1422-0067/24/8/7614 |
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