Nanotechnology and Tumor Imaging: Seizing an Opportunity
Nanoparticles, labeled with a signaling moiety for in vivo imaging, and one or more ligands for molecularly targeted specificity, hold considerable promise in oncology. Nanoparticles can serve as modular platforms, from which a wide variety of highly sensitive and specific imaging agents can be crea...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2004-10-01
|
| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1162/15353500200404139 |
| _version_ | 1797285287559168000 |
|---|---|
| author | Daniel C. Sullivan Mauro Ferrari |
| author_facet | Daniel C. Sullivan Mauro Ferrari |
| author_sort | Daniel C. Sullivan |
| collection | DOAJ |
| description | Nanoparticles, labeled with a signaling moiety for in vivo imaging, and one or more ligands for molecularly targeted specificity, hold considerable promise in oncology. Nanoparticles can serve as modular platforms, from which a wide variety of highly sensitive and specific imaging agents can be created. For example, many hundreds or thousands of atoms that provide imaging signals, such as radioisotopes, lanthanides, or fluorophores, can be attached to each nanoparticle, to form imaging agents that would provide higher sensitivity that can be obtained from agents based on small molecules. Similarly, many copies of targeted ligands can be attached to nanoparticles to markedly inrease specific binding. Drugs or therapeutic isotopes can be added to create multifunctional nanoparticles. Appropriately labeled and targeted nanoparticles could lead to a paradigm change in which cancer detection, diagnosis, and therapy are combined in a single molecular complex. |
| first_indexed | 2024-03-07T18:00:59Z |
| format | Article |
| id | doaj.art-bac8c31e171a42428a98bf30fc0932db |
| institution | Directory Open Access Journal |
| issn | 1536-0121 |
| language | English |
| last_indexed | 2024-03-07T18:00:59Z |
| publishDate | 2004-10-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj.art-bac8c31e171a42428a98bf30fc0932db2024-03-02T10:53:03ZengSAGE PublicationsMolecular Imaging1536-01212004-10-01310.1162/1535350020040413910.1162_15353500200404139Nanotechnology and Tumor Imaging: Seizing an OpportunityDaniel C. Sullivan0Mauro Ferrari1National Cancer InstituteThe Ohio State UniversityNanoparticles, labeled with a signaling moiety for in vivo imaging, and one or more ligands for molecularly targeted specificity, hold considerable promise in oncology. Nanoparticles can serve as modular platforms, from which a wide variety of highly sensitive and specific imaging agents can be created. For example, many hundreds or thousands of atoms that provide imaging signals, such as radioisotopes, lanthanides, or fluorophores, can be attached to each nanoparticle, to form imaging agents that would provide higher sensitivity that can be obtained from agents based on small molecules. Similarly, many copies of targeted ligands can be attached to nanoparticles to markedly inrease specific binding. Drugs or therapeutic isotopes can be added to create multifunctional nanoparticles. Appropriately labeled and targeted nanoparticles could lead to a paradigm change in which cancer detection, diagnosis, and therapy are combined in a single molecular complex.https://doi.org/10.1162/15353500200404139 |
| spellingShingle | Daniel C. Sullivan Mauro Ferrari Nanotechnology and Tumor Imaging: Seizing an Opportunity Molecular Imaging |
| title | Nanotechnology and Tumor Imaging: Seizing an Opportunity |
| title_full | Nanotechnology and Tumor Imaging: Seizing an Opportunity |
| title_fullStr | Nanotechnology and Tumor Imaging: Seizing an Opportunity |
| title_full_unstemmed | Nanotechnology and Tumor Imaging: Seizing an Opportunity |
| title_short | Nanotechnology and Tumor Imaging: Seizing an Opportunity |
| title_sort | nanotechnology and tumor imaging seizing an opportunity |
| url | https://doi.org/10.1162/15353500200404139 |
| work_keys_str_mv | AT danielcsullivan nanotechnologyandtumorimagingseizinganopportunity AT mauroferrari nanotechnologyandtumorimagingseizinganopportunity |